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If I could pay a deposit upfront for the device, I would be happy to do so. And certainly, so would many other tinnitus sufferers. They would have a guaranteed source of funding...

As of 2020, I have a reserve of $10,000 set aside for Dr. Shore's device. So far, it doesn't seem that Auricle is interested in it. It's a business model to think about.

I checked out the Lenire website. I was very surprised at how many places are marked on the map where you can get the device — hundreds of cities. So, I would expect hundreds of patient experiences to come. There are only two options. Patients are not interested in Lenire, or are not interested...

How do you take Ketamine? Intravenously? And how much? Thank you.

The announcement that they will submit for FDA approval in Q1 means that they will submit March 31st, at 23:59:59? :)

I'm a layman in this so it doesn't make sense to me that Eglumegad is a glutamate agonist. I thought that tinnitus was the result of overactive cells that needed to be calmed down. So I would expect a glutamate antagonist to work, not an agonist. Does anyone know?

Do you think Dr. Shore's device will be personalized? Any special setting for each person? For example, according to hearing loss, or tinnitus frequency? I'm asking if it would be possible for someone from Europe to secure 2 devices and sell one to me when visiting the USA. Auricle would lose...

The approaching competition, for example NUEYNE-T100, may lead Auricle to change its strategy and come to other continents earlier. Let's hope.

What does the timeline in the picture mean? Is the device in the commercialization stage for migraine? If it becomes available for migraine, can I buy it and use it for tinnitus? Is it that simple?

We cannot look for similarities between probably the most complicated medical device (MRI) and Auricle. For me, personally, nothing can explain why Auricle's commercialization can take so long.

After such estimates, I feel that Auricle's device is moving farther away, not closer. Each subsequent estimate gets longer and longer. If it goes on like this, year by year, without access to the device, it may well happen that some other device or drug will overtake Auricle. I personally wish...

Many sufferers have suicidal thoughts. It seems inhumane to me that we don't even know an estimate of how many years we will have to wait for help, even though the device has been tested. It is extremely frustrating. The obstacle to my normal life is actually bureaucracy...

If this is true, it is absolutely incomprehensible, like all the delays related to the device. I am extremely disappointed and distraught.

Whether this device, which we are waiting for so impatiently, really works, we will find out only when we use it for 6 weeks. Everything else is conjecture. Hopefully I'll have it on my head as soon as possible...

Do you think the FDA is investigating the manufacturing and distribution potential of the device? That would be strange. Either the device is safe for humans or it is not. How the owner handles it should not be of any interest to the FDA. Or?

They have to start somewhere. They probably won't wait until 1,000 ENTs are ready to start all at once. Lenire also started first in its head office and gradually added doctors. It will be very similar with Auricle. They will start somewhere and gradually increase. Otherwise it would have no logic.

Hopefully, while the FDA is reviewing the matter, Auricle will reach out to at least a few ENTs, so that for the most desperate people, the treatment is available as soon as possible. Every day is extremely difficult.

We can certainly deduce that the matter is already being handled by the FDA. Hopefully things won't get stuck, and we can book consultations and get the device soon. I don't care which ear doctor offers the device first, I will fly to the end of the world.

I was in a psychiatric hospital 3 times. I was hospitalized for half a year in total. Because I saw a way out only in suicide. Unfortunately, they didn't let me turn the beast down even a single decibel. Every day is suffering. Every hour, every minute. BUT! Experts say help is damn near at...

Please excuse me, I don't understand your post at all. What exactly does this mean for Auricle's FDA process? Does the judging start from scratch? In a stricter mode? Thank you.

I'm not familiar with potassium channels at all, but I understand in layman's terms that one is looking for a channel opener, not a blocker. Even the reformulated Trobalt should be a channel opener. So, if the solution is to open the channels, Amitriptyline as a blocker is very unsuitable for...

What does that mean? Is Amitriptyline being a potassium channel blocker good or bad for tinnitus?

Why do you think that is relevant or important?

I know exactly what you are going through. My family broke up too, I lost my job. I am in tears every day. Over 5 years of tinnitus, I have accumulated a deficit of thousands of hours of sleep. No one understands that the cursed sound is like razor blades in the ears and in the brain. I tried...

Please, does anyone know when Dr. Shore's device will be available? I have a noose around my neck, I can't live anymore. I hate this world where papers and permits are more important than human life. :(

I think there will be progress in September. Another graph! :/

This is exactly what raises my doubts. Such a serious and significant matter and Auricle is unable to provide the public with an anticipated timetable. Only conjectures, hopes, desires... Incomprehensible.

Where is this chart from? It is quite incomprehensible. What does active first mean? Control first? Why do columns start at zero? Anyone had zero tinnitus years? Can someone explain in detail what data this chart shows? I don't understand why everyone still has such high hopes for this device...

Another "Michigan" device?

The smallest dose of Ivabradine is 5 mg. Even though I only took half of that, I still had pain in my heart. I had to stop taking it. I'm not going to risk my heart. The experiment did not bring success :/

Third day Ivabradine 5 mg daily. I just took my heart rate - 49. OMG. I'm normally in the 70s to 90s due to stress and anxiety from the tinnitus. No change in tinnitus yet.

I see no point in measuring the intensity of suffering. When the device shows a number, then what? The suffering continues...

I got Ivabradine first. I'll try itfor a few weeks. I won't try Latuda, but when I finish Ivabradine, I will then try Reagila (Cariprazine).

I'm going to try Ivabradine. Off label. Fingers crossed, I'm going to be a guinea pig. I will try anything, I can't describe the suffering. I will keep you updated...

After 10 years of research, the two graphs from December 2022 Palm Springs Hearing Seminar showed that the device increased the volume of tinnitus in some people. Where do you get so many "guaranteed" reports that everything is great?

But Latuda is a very interesting medicine. It is quite new. And it works on DCN! I will ask the doctor to try it. Latuda has the active ingredient Lurasidone. But the drug Reagila (trade name in Slovakia) has the active substance Cariprazine. Cariprazine is mentioned in the materials. Should I...

Any reasonable investor would look for a way to make a profit as soon as possible. If profit is faster in the EU than in the US, it would be logical...

Prof. Thanos Tzounopoulos admitted that he has tinnitus in one interview. But I have no knowledge of whether Dr. Shore has tinnitus.

Statistics can be deceiving. 50% of participants had an improvement. It's like "with chicken". I'll eat one chicken, you none. Statistically, we both ate half the chicken. Forgive my skepticism, but I really expected better results. At least 75% of the participants would deserve a moderate and...

The scatter graph looks like the post-treatment data because there are two types of data, active group and control group. Both groups experienced worsening. Without explanations from Dr. Shore, it looks very disturbing to me. Hopefully everything will be explained soon.

I am totally confused by that graph. There are purple dots in the upper left quadrant, at the very top. Has someone in the trial had their tinnitus increase by more than 20 dB (1 unit is 6 dB) and at the same time had their TFI decrease by about 13 points (1 unit is 13 points)? Because those...

In the bottom graph, did all the purple points above the zero axis mean an increase in tinnitus volume? How do you understand the bottom graph?

If 75% reduction in tinnitus loudness is an average number, someone must have had an even bigger reduction. Mathematics... do I understand it correctly?

I'm worried we won't learn anything relevant at the Palm Springs Hearing Seminar. General information about the second clinical trial and general thoughts on how to proceed. But the concrete conclusion, to what extent and how many people the device helped, will remain secret. By the way, I can...

HHC was first created in 1944 by American chemist Roger Adams when he added hydrogen molecules to delta-9 THC. This process, known as hydrogenation, converted THC into hexahydrocannabinol (HHC). I tried smoking HHC. Unfortunately, it didn't help :(

The lecturer assumes one more year until commercialization. Did I understand this correctly?

Ketamine is a drug. It is said to induce a very pleasant state. Well-being, relaxation. It caused me an indescribable feeling of dread. I was very dizzy. I lost my orientation in time and space. I got a crazy fear that this condition will remain. I felt like I was stuck in it for 3 days. Horror...

Try to agree on a half dose, for example. I was scheduled for 3 doses, with a break of 2 days, but I already refused the third, even though the doctor convinced me to endure it. It was unbearable. Really indescribable feeling.

When I had Ketamine in my veins, I felt like I had one foot in hell. My tinnitus went 300% higher. This state lasted about 2 hours, but felt like it lasted 3 days. Ketamine never again. One Professor used my case in his textbook as an unexpected reaction.

i tried this combination (Sulpiride + Hydroxyzine) for several weeks and it didn't help at all.

It is surprising that the US Military is not involved in this matter, since there are so many veterans suffering from tinnitus. The Military should have an influence on speeding up the introduction of treatments for tinnitus sufferers...

If they made a thorough advertisement that an uncertified device can make tinnitus worse, I wouldn't buy it from China. Even if it cost one dollar.

We will go together.

We don't know when it will be, but one day there will be a time when Dr. Shore's device will be a pile of scrap, because there will be effective medicines for tinnitus. What a paradox...

But graph A shows that the second use was even more effective.

Design year 1990.

No! It is not. I took 1 mg a day for 2 weeks. No side effects.

No. Only Psilocybin. Grown at home :)

Psilocybin does not work for me :/ Done microdosing for 2 weeks, daily.