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It happened again today. I am certain it is something of cochlear origin—there is no way it is just in the brain. I have dysautonomia, so I have attributed it to either vasospasm or vasoconstriction in the inner ear, or perhaps fluid pressure buildup, similar to what occurs in hydrops. I cannot...

It's marginally off-topic, but the entire FDA is getting gutted, apparently. The last time Trump was in office, he cut a tremendous amount of red tape within the FDA. Regardless of your politics, this should be good for us, right?

She speculated that it might work for both in the Q&A. Technically you can't ask a guinea pig if it has somatic tinnitus, then again you can't ask if your tinnitus machine worked either.

Apparently, Tofisopam can cause tinnitus as its sole withdrawal symptom. How perfect for us. Source: A Comparison of the Anxiolytic Properties of Tofisopam and Diazepam: A Double-Blind, Randomized, Crossover, Placebo-Controlled Pilot Study

Ugh. This just happened again, and it’s so scary. I really hope it’s benign.

There are two components to the etiology of tinnitus: the peripheral issue and the central generation. TMJ dysfunction and Meniere's disease are fundamentally different conditions, so it's reasonable to consider their resulting tinnitus as having different etiologies. However, the tinnitus is...

It might not be the only treatment. There was a recent double-blinded randomized placebo-controlled trial that showed tDCS over the auditory cortex reduced TFI from an average of 75 to 45, and I'm sure that entails volume reduction. No one talks about it, but it had incredible results. For...

Many of us with damaged ears can get an acoustic trauma from noises barely north of 100 dB. Mine was a deaf cat screeching 5 feet away from me.

There's a user experiences thread with 50+ reports. Most people say it's trash.

Has anyone tried this yet? It seems too good to be true.

I think Dr. Shore's placebo was related to the timing.

Is there any update on the Cerebrolysin? That's great that something seemed to work.

By some accounts, it helps MOST people—I've heard 75%, according to one audiologist. Never forget the sampling bias of getting your reviews from a sick-person forum. Don't get me wrong; I'm still afraid to try it, but thousands of people have now used Lenire, and almost no one on Tinnitus Talk has.

It depends on how often it gets catastrophic. I've had horrific 9/10 tinnitus plenty of times, but I've been blessed with a 4/10 baseline for the better part of the last couple of years. In essence, anything that is temporary is bearable when it acts up. It's the only mentality to take for such...

I was just exposed to a very loud firework from a distant neighbor. I don't know how far away it was, but I'd guess it was anywhere in the 95-102 db range. It was a very low-frequency "thud" sound and even had a bit of a shockwave. Like most people on this forum, I have noise-induced tinnitus...

Microsuction is the worst. I've had it done twice, and the second time gave me a horrible spike. In the future, find a skilled ENT and insist they get the wax out MANUALLY. It's very safe if done in the right hands. My hyperacusis went 90% away over the course of 1-2 years. I can finally go...

I don't know if this has been mentioned yet, but XEN1101 is supposed to have side effects comparable to those of most other anticonvulsants. I specifically remember that from one of Xenon Pharmaceuticals' PowerPoint slides after the Phase 2 trials came out. I'd rather not go digging for the...

tDCS has some solid evidence that it helps tinnitus, but very few mentions of it in the community for some reason. I would trust tDCS WAY before I'd trust TMS. I personally know of three cases where TMS made the patients' tinnitus worse; two were former patients of my audiologist, and one was...

The more I learn about this device, the more optimistic I get that it does actually work. The only thing I'm still apprehensive about is the tone matching. Many people here have crazy broadband sounds that would be challenging to match correctly. Personally, I've had sounds that are like if you...

Botox should have the same effect, no?

Vinpocetine does the same thing, I believe, but without the erections.

Some cannabinoids are also modulators of 5-HT1a. This is 100% anecdotal on my part, but CBD (5-HT1A agonist) tends to make my tinnitus worse than CBG (5-HT1A antagonist).

I agree with almost everything you said, but the CEO of Neuromod has a PhD in biomedical engineering and did his undergrad in electrical engineering, and has explicitly stated that the latency has been corrected for.

That's really unfortunate. Hopefully, it lightens up eventually, as it does with many other people. You're not the first person on here who's gotten worse tinnitus from the iodine contrast from a CTA scan; that's what it was, right? Or was it an MRA scan?

Verapamil is also an L-type calcium channel blocker, and it's a much more commonly used drug than Nimodipine. A quick search of Reddit yielded 1 improvement and 2 worsenings of tinnitus caused by Verapamil. That makes sense, given that it drops blood pressure, and hypotensive drugs (like...

The two-year threshold is so out of their ass. At the risk of coming across like a simpleton, it'll either work for tinnitus or it won't. I don't believe this condition has a million and one different etiologies.

Don't forget, we also have @kelpiemsp here who says Hubert Lim's method worked for and it actually eliminated his tinnitus, not just improved it.

YMMV, but muscle relaxers have this effect for some people.

"Like the shirt on your back" —Hubert Lim

People with mild tinnitus talk about a placebo, but people with soul-shattering tinnitus know that a placebo doesn't touch it.

Lenire seems to be exploding in name recognition and popularity, and I'm starting to question whether the minuscule sample size we have here—from two years ago—is breeding unwarranted skepticism. Don't get me wrong; I'm still afraid to try it, but thousands of people have now. I just want to...

I've often wondered how sustainable it is to cycle benzos indefinitely without building tolerance and withdrawal. Maybe once per week? Twice per week? It probably depends on the benzo.

There's another HCN modulator called Guanfacine, which is an a2-adreno agonist like Clonidine used for ADHD. I tried making a survey here about its effect on tinnitus, but the sample size is too small: Can Guanfacine Make Tinnitus Worse?

Did Paxlovid have any effect on your tinnitus?

Nimodipine is used pretty exclusively for hemorrhagic strokes. It's not something used for chronic blood pressure.

It's between this and a beta-blocker for me. It would be great if drug surveys on Tinnitus Talk had a larger sample size given the size of this community. I know it's a crap shoot, but some drugs have a much higher probability of causing tinnitus.

Lenire didn't take long to get to US market after FDA approval; I think it was about a year? Auricle is seeming like mid-2025.

My hyperacusis has been almost non-existent for the last year. It used to be so bad the sound of my own voice would hurt my ears.

Do you have a source for this? I looked into this a few years ago and I remember the results were all over the place.

Depends on what proof means. The TENT-A2 studies show a definitive improvement in TFI, but I forget why it was dismissed as p-hacking by some people on Tinnitus Talk.

I get this exact thing when I'm stressed. Thankfully it never lasts more than 3 weeks at a time. It seems to be the type of sound that goes away most consistently for me.

Just the term "tinnitus memory" is an assumptive premise. Are they saying it happens once and then gets stuck, or what? It's all just speculation on their part.

They're scary, whatever they are. How are you doing now?

Stories like these are enough to scare me away from looking into cochlear implants. They do give some people tinnitus, maybe because it's such a destructive procedure.

This is exactly what OTO-413 was I believe, are there any differences?

Over the last few years, I get a strange type of pressure attack in my ears, where my hearing gets muffled and I hear a low-frequency droning sound, with a lot of bilateral pressure in my ears. It lasts for about 5-10 seconds, and happens to me about 5 times per year, so it's not often. It's...

Don't forget that DBS involves an MRI scan. They're insanely loud and some people have claimed it's spiked them. My scan didn't seem to affect my tinnitus, but I had a quieter machine.

I believe it was in a video interview with the CEO Ross O'Neill, from like 5 years ago. Not saying I would risk using the device personally, but it was said that people with good hearing and hyperacusis were the highest responders.

Interesting, I would love to hear from any members that take Metformin. It's one of the few drugs that has been shown to reduce the chance of getting long Covid. A 40% decreased chance, IIRC.

I was referring to their tinnitus.

I remember reading that hyperacusis patients have the most success with Lenire.

Reminder that this process involves MRI imaging. That's 20 minutes of 105-110 dB.

Vinpocetine is the only compound I've ever seen that has actually been shown to improve hearing over time. There are other compounds that have been shown to salvage hearing after an acoustic trauma, but this is different. This study says that Vinpocetine actually improves pre-existing hearing...

Neosensory recently published a controlled trial of their device and found it to be quite effective for tinnitus. What do you all think of this? The control had no vibration, so they were still in theory susceptible to placebo.

The more I read about Dr. Shore's device, the more my intuition is telling me it won't help with low-frequency droning, humming and rumbling type sounds, like those common of endolymphatic hydrops. Hope I'm wrong!

@Tau, did this work for you?

Is it possible that XEN1101 could cause tolerance and subsequent withdrawal in a way does the opposite of its intended effect? Many of the drugs on here that people love (e.g., Klonopin, Mirtazapine) are wonderful until you become tolerant and the subsequent withdrawal process begins and makes...