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Trobalt (retigabine) is a very different kind of dope :p Just to be clear Retigabine ≠AUT00063 by any mean, they happen to act in the same area but in radically different manners. Plus the retigabine is not meant for T. and its scope's too wide to be viable and it has numerous side effects. As...

Very unlikely, I can't think of any physiological reason for this to happen, there is no more reason for this than a reason for the drug to grow a penis on your forehead and transform you in a unicorn. haha (Worst case scenario would be it go back to how it was before because plasticity did...

Haha you got me :) :p

Many people would give anything for having at least a rat model for a cure for cancer, ALS, or HIV... If we are not positive, who can be ? The T. mechanism has been figured out, research will just brute force the lock until it opens, and I have no doubt it will be very soon.

In a nutshell I have a background in applied economics (lol), I drifted to applied maths and computer science, I was more specialised in behavioral models for virtual worlds but I happened to work a lot on neuroscience. ;) (edit: I was creating computer programs to mimic some regions of the...

Shit you got me !!! Well they should pay me for promoting their dope :p

Sorry to interfer here, but it has nothing to do with partial seizure... Most anti convulsant are sodium blockers, meaning that when you block sodium it gives potassium much more freedom of actions and impact. This is why some people get lidocain perfusions, it's a major sodium blocker and will...

Kv3.1 was heavily documented as the main channel for T. considering the number of papers confirming it, I doubt Kv7 is a winner. As I explained earlier Kv7 targeted by retigabine acts on interspike interval, meaning less T. spikes and it can possibly repolarize the action potential for some...

Yes, ototoxicity can be caused by noise, drugs or stress. EDIT: basically most of T. should be tackle (theorically) by AUT00063 providing it works as expected. The T. not directly curable by this (TMJ, tumor, edema as eg) are curable if the initial problem is fixed. (eg, if you can get a...

@Christian_B first it's a bit out of my area of expertise, I am quite confortable with the brain, but I did not work much on any other area of the body :p So from my perspective I don't recall any article showing that TMJ can cause excitotoxicity. (Anyone found something about this ?) It's...

@cdog I like you enthousiasm and motivation, but you don't know when to stop, do you lol? Seriously even with a lot of efforts I don't understand nor your point nor your question here. *__* Dude synapse are in 2 parts like talkie walkie emetor & receptor, if one if not working you just can't...

No I called the theories I read above "crazy" because they are as crazy as not suported by scientific evidence. Yes the mechanisms above were confirmed on human, and it has been documented for the last 20 years with numerous articles. ==> google is your friend. For the "idiots" comment, in case...

Wow, I have been in this thread for a few days and it's like war here. *__* I am really busy at the moment but I have seen so much misinformation around that it will be useful if I clear a few things out. You guys seem to trip on the area I did not explain much because of its complexity...

Hey guys, I am kind of off at the moment as I have a lot of work, I see a few discussion around topics that I already covered, maybe it can help to quote some info here! : The impact of retigabine on Kv3 is not necessary related to dosage but more a "physiological response" to the drug, like...

I am more this kind of detective :p @LondonGirl

It is linked to the hair cell, but what I am saying is that sometimes they die in big number and lead to a hearing loss, but not enough glutamate was released to mess up with the potassium channels. (Hearing loss, no t.) The other way is that they die in smaller number not leading to a...

The way I see it the problem is not the death of hair cells, some people experience it and just have hearing loss. The problem is the chain reaction of an excess of glutamate. There is no idea of "deterioration" in the sense the auditory system is "broken", it was proven that the auditory...

I just mean I can share with him the mail exchange in case some people doubt of the origin of the information. ;)

I never though about that actually, it's quite an idea man, I will do some research if from the action potential you can deduce how the signal is interpreted by the brain :eek: Wow actually your idea is mind blowing. (heavy breathing :3 ) If from the bursting activity in principal cells can be...

Ok guys, I have an exclusive information, I am discussing with people working on the AM-101 trial (I won't disclose their names, but if need be I can PM to @Markku to legitimize it). First information the time frame for the drug efficiency was decreased to 2 months (2,5 max) with the best...

Go back in the thread, I extensively explain why :p

We discussed the fast track earlier or in another topic, but it's not black or white. I agree that we may not have a fast track like for a cancer drug, but early access to the drug can be done in many other ways (extentend trials, off trial distribution, etc...) Also I think the medical...

Engurish good in me, takke me pleese !

Hey Freddie, Yeah the drug is expected to work no matter the time frame, it may just take longer for older T., but it will work too. They want new T. for their proof of concept, let's not forget they are a company first, they want spetacular & fast results so they go for recent T (easy mode)...

The article you mentionned is anterior to hamann/page findings as said by @rtwombly Dude the answer to the glutamate thing is in the first quote, it's funny coz you're the second one I give it and who re-ask the same thing. :cat: No Rage :cat: (jk I don't mind to help!) First link, page 11...

Very similar to the pricing above in the canadian pharmacy.

Do you have a link, I am curious to see what it looks like.

My mother is a Professor in Dominican Republic, so she looked up for me, she told me there is a lot of fake drug coming from india there. I doubt I could find it in Mexico with my network.

Correct you can have T. without hearing loss, and hearing loss without T. :)

I found Potiga in Dominican republic but I don't trust them and I don't want to risk to take some crap. I would avoid Mexico if I were you.

@Zimichael , thanks a lot for the message, I ready to start our bromance anytime, just let me know a few weeks in advance so I can divorce too. I'll have a look at the retigabine, but I am puting this on hold while I go on holidays in september. Almost 1 month in hawaii ! yay ! Back to the...

Hey! Thanks for the feedbacks I really appreciate. @undecided haha don't shower yourself with trobalt. I have simplified things an awful lot here. There is not only one type of potassium gate, there is actually a lot, and T. seems to affect only one specific type the Kv3.1. Trobalt acts on some...

Haha I know the feeling, what do you play man ?

Hi @cdog , Thanks for your comment, it's pretty late here in montreal, so I'll be short :) (EDIT: I wanted to be short, but I could not resist writing a lot lol, I am such a failure haha) I think I already covered this question a few weeks ago, maybe this is what you're looking for: If not we...

I stop playing the way I did, but I kept playing for myself, not as much as I would like, but just enough not to forget how much I love playing music :)

yeah most T. share the potassium channel issue, only blood circulation related T. and some mechanical T. are the exception. Feel free to PM if you have more question ! Not to hijack too much this thread :D

Don't fear too much, the literature is very weak on those glutamate excess mechanisms, or at least what I can find :p If they bothered doing a trial on such a time frame, there's maybe the possibility for some potential effect after a longer period than the 3 months. That being said, as I...

The hair cell death process I mentionned was observed on rat, I assume it might be a bit longer for humans. Now I believe they probably have some evidence that the excess of glutamate in most case can go up to 3 months so this is why they segmented the population. The other group is in my...

Hey Mr Hijacker :p I think the sooner the AM-101 is taken, the most effective it will be. Your confusion comes from the fact that you assume that the excess of glumate is permatent. This is not true, it's very short and the death process of hair cell is matter of week. It was mainly tested on...

Thanks for the comment. I am not sure which post you're making a refence to, but I think I was talking about the cellular level for the hair cell degeneration as well as the glutamate "overdose". Brain plasticity is a very dense area of research with many ramification. Plasticity can be of many...

Hey guys for the one who just got in the thread, I have explained several times why time has NO impact on the reversability of T. Time only matters in the first days maybe weeks for the glutamate saturation, it's tackled by the AM-101. For the rest of us after the glutamate induced the T...

Hey iAzara, steroid won't do much for a spike I think, they are useful in the next 24h/48h of a recent increase related to an acoustic trauma. I was using prednisolone, high dosage for 4 days.

Pretty good definition, this is where we are at the moment but those are not definitive values, this is a first guess for research purpose. I expect those ranges to change a lot.

The AM-101 is intratympanic because it's a localized glutamate blocker, but if the the AM-102 is targetting potassium channels, there is no reason it should be an injection, so most likely pills. But again we are supposing a lot of stuff here ;) Let's wait for more info!

Surprising story guys, I mentionned a while ago that I luckily met the person in charge of the AM-101 in Mtl thanks to my audiologist, and I just had her assistant on the phone and they are considering taking chronic T. people who had a recent (last 18months) increase to try the AM-101. The...

Yeah, they are fine tuning the drug on rats at the moment :) Then it will go to clinical trials (phase 1 & so on).

Ok guys my 2 cents AM-102 = AUT00063 and will target Kv3.1 potassium channels.

Yeah I agree with ya, you're a smart one, you figured out on your own what decades of T. research just found. Your statement fits perfectly with the latest work of Dr Hall (Autifony) The article: http://informahealthcare.com/doi/pdf/10.3109/14992027.2013.846482 For the lazy one: Auditory...

Instructions unclear, dick stuck on ceiling fan. Please advise.

Yeah of course you can :) Also feel free to PM me if you have questions.

Hey, welcome here, Activan is not a cure for T., it just help you sleep, you can stop it if you are not confortable with it. You should consult an ENT if it's not already done, there is something causing the T. you have to figure out what it is. Consider a MRI too if available. I suggest you to...

For Xanax there was a study in the early 90's that was unfortunately not replicated to my knowledge: http://www.ncbi.nlm.nih.gov/pubmed/8343245 The Xanax molecule, the Alprazolam binds to the benzodiazepine site of the GABAA receptor, where it acts as a GABA agonist by increasing the...

No, unfortunately sound has no known positive effect on potassium channels, (maybe someone has an article ?) Anyway, when you hear a sound for a continuous time and stop it, this has some sort of residual effect on the auditory cortex, to put it simply it happens when the brain is going to look...

Hey Christian, don't forget the primary effect of this drug (on the paper) is to control spikes, it can potentially reduce the T. but it's not specific enough to be efficient on a wide range of patients. I explained this point in a previous post. Did it have any impact on your spikes at the moment?

This is not a miracle drug by any mean, it's just a somewhat close to what could work.

Yeah I figured it out, plus the drug range of action seems to be too much in the middle & vague. Thanks for the confirmation <3

Most of the big ones are lol It's just they all bet on different stuff related to the Glutamate/Potassium interaction GSK, Pfizer Venture --> autifony (Potassium) http://www.imperialinnovations.co.uk/news-centre/news/autifony-initiates-phase-i-trial-treatment-hearing/ (I have no doubt this one...

My T. is also increased when I am under too much stress/ frustration, it's a negative spiral that I try to avoid (too much stress => more T. => more stress => more T.) When this happens, I try to do much more sport than usual, I put a little white noise background with some music I like, I take...

Sorry to hear that. :( Do you have antecedent of stress induced T. ?