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What are the differences between acute and chronic hyperacusis?

So there are no solutions for someone who suffers from noxacusis?

I have good hearing up to 8000 Hz according to various audiograms. I have tinnitus with different tones and a very strong case of noxacusis. Is it possible that I have profound hearing loss in frequencies above 8000 Hz? Could I have lost support cells in the high frequencies? How can I find out?

So OTO-313 doesn't work for chronic tinnitus? It's only for acute tinnitus?

Are we sure SPI-1005 would cure noxacusis? Completely?

When will the clinical trials in Europe start?

Tinnitus is just a symptom and we can't die from it. So, it's not important for others. The only solutions are waiting for treatments or committing suicide. And if you commit suicide, it's your problem, not the doctor's.

Will there be a phase 2B?

Hello, I have had tinnitus, hyperacusis / noxacusis and cracking ears for 1 year. In 1 year, my life has changed, I hardly go out and often afterwards my ears hurt. We are told that there are drugs coming out. If we look closely, we have been waiting all the time for solutions with hope and...

Wait for treatment or crack and die. As Bon Jovi would say, it's my life.

Hello, do we know when the clinical trials will be done in Europe? And where?

@dan26 No one on Tinnitus Talk would benefit from it if it was only for people who have had tinnitus for less than a year. The drug will be in development for another year, then there are the clinical trial testing phases. It would be available in 7 years. If this is the case, we can abandon...

Hello! Do you think that with the second wave of COVID-19 in the United States, the testing of the FX-322 could be even further delayed?

Hello! Will Thanos' treatment be reserved for people with tinnitus less than a year old?

@Jaysterk Personally, I think there are more than we think. FX-322 repairs the inner ear. There may be damage to the middle ear for example. Many after hearing trauma suffer from TTTS and may have tinnitus related to this: pulsatile tinnitus or normal tinnitus. At that time, even if you...

I hope that it's not the end. It's impossible for me to live with tinnitus and hyperacusis the rest of my life. I'm so sad. I would like to see the end and to have a real life. I miss my old life.

On Tinnitus Talk, we all have different tinnitus (intensity and sound). How with the same dosage of this drug it will affect us? Will some people need to take more medication than others?

When could this treatment become available?

@Nobody19 In the previous pages, I asked if FX-322 would help with TTTS, the answer was yes. I asked how it could be, I didn't get an answer. https://www.tinnitustalk.com/posts/525190/

Hello, sorry to disturb you but I am desperate. I suffer from TTTS. I was told on Tinnitus Talk that FX-322 will cure problems of TTTS (pulsatile tinnitus, cracking, fullness). Could someone explain to me how the drug would help knowing that it acts on the inner ear?

@Coleoptere what do you mean "by same success rate"? According to @FGG, it's not the same treatment. FX-322 is better.

So the person who was cured thanks to this treatment, it's a fake legend? No real results? I hope FX-322 will be different. It's difficult to keep the faith.

How could FX-322 cure tonic tensor tympani syndrome? In effect, FX-322 acts on the inner ear whereas the TTTS is a problem originating in the middle ear. The person who was cured by Audion is perhaps a "legend", what do you think? Audion still has not released the results which may be...

An improvement of 10dB, even if it's better than nothing, don't you think it's too little to regain hearing or reduce tinnitus? We may have a greater loss on high frequencies. Do you think FX-322 could have a positive effect on TTTS?

Do you know when the clinical trials will start in Europe?

We have only 10 years left to live in suffering hoping that the clinical trials will work out.

The clinical trials are taking place in a year and a half. When can we imagine the drug coming out? He tries it on rodents who have had tinnitus for less than 6 months. Will the medication be reserved for acute tinnitus?

The clinical trials will be done within a year and a half. We are not ready to be saved.

Come on Prof. Tzounopoulos, yes you can!!! We would like a piece of good news.

When you say "Regenerating hair cells may be helpful in patients suffering from tinnitus accompanied by hearing loss" mean that even with this treatment if we take it and it restores our hearing, tinnitus can stay at the same level without any improvement?

What is the difference between the Hough Ear Pill and OTO-413? They are both for synapses, one is a pill and the other is an ear injection. In terms of efficacy, is it the same?

The Hough pill is also for acute tinnitus. It is apparently easier to repair acute tinnitus. What I don't understand is the difference between acute and chronic tinnitus in the ear and the brain?

I feel like all the treatments cure acute tinnitus, not chronic. It's a shame and I don't understand because even if the number of tinnitus sufferers increase, there are many chronic tinnitus sufferers who have suffered for years.

Where are the clinical trials for Audion / Regain done? I did not find it on their website.

I have had pulsatile tinnitus above my normak tinnitus for 1 week. Can Dr. Shore's device work on pulsatile tinnitus? And, if we have several tinnitus sounds in one ear, how will this be programmed?

Do you think that hearing regeneration treatments could cure or reduce hyperacusis / noxacusis?

Within 5 years, we will be able to regenerate our cochlea thanks to FX-322 (OHC and IHC) and the Hough pill (synaptopathy and auditory nerve). It would be fabulous.

@FGG I don't understand anything anymore. It was mentioned in their patent: "In certain embodiments, the present disclosure relates to inducing, promoting, or enhancing the growth, proliferation or regeneration of inner ear tissue, particularly inner ear supporting cells and hair cells." It...

From what I understand, it is from the support cells that the FX-322 remakes OHC and IHC. Apparently it works better with IHCs. Apparently it would also rebuild support cells. It should also be injected several times if I'm not mistaken.

Excuse me, I don't speak English very well, I'm French. So isn't the Hough pill just for acute tinnitus? I contacted them to find out where they will be doing their clinical trials and whether there will be any in the EU. Have you got any news ? If yes, do you know if they will have clinical...

Is it still possible to register?

Hello, everyone, I don't understand one thing about the FX-322 and the patent: - How can they know that the FX-322 is replacing support cells? - And in what cases?

I do not see that this subject has been approached. I have read the whole thread and have found nothing. My questions are: - Do you think FX-322 could restore dead hair cells that have died from ototoxic drugs? - I think ototoxic drugs are more devastating than loud sound and can kill...

Do you think FX-322 can have an effect on hyperacusis? How long would it take before becoming available in Europe?

Do you think that hearing regeneration treatments could help against hyperacusis?

How do you know Hough Ear Institute's pill will be released in mid-2020? They are in the testing phase.

@Mentos When you say the treatment repairs nerve endings, are you talking about the auditory nerve?

You are talking about support cells, the auditory nerve and other things that can be killed by ototoxic drugs. Can damage to the auditory nerve and support cells cause tinnitus? For the hair cells and the synapses, there will be treatments but what about for the others? At that time, if you...

@brokensoul Thanks for your reply, what do you mean by other non-cochlear damage? In the auditory system, what would be affected and could cause the tinnitus except IHC, OHC and synapses?

Thank you for your answers. @FGG If I understand correctly, restoring hearing will reduce or eliminate tinnitus, is that for sure? An ORL in France told me that once the acute period ended, the tinnitus was ingrained in the brain. There was nothing to do except to get used to it. By...

I had an acoustic trauma in August 2019. It got worse by taking ototoxic drugs (Doliprane) and with TRT. How do you know where the damage is? You talk about other structures (for example, Stria Vascularis or even brainstem structures), can these cause tinnitus? There is no research on...