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The three months before I had full-onset Tinnitus I had more frequent and louder fleeting tinnitus episodes. Maybe a couple times each week. I just figured it was a weird little neuro-quirk that I was going through. I had no idea that there was such a thing as chronic permanent tinnitus. I would...

Thanks for your thoughts FGG. You’re right. I appreciate your view very much. And the follow-up session you did on the FX-322 in the Tinnitus Talk Podcast was awesome.

Thanks FGG for your comment. I had some razor burn that got infected. It wasn’t bleeding out, just ugly and red. I’d say it was fairly superficial. I agree that this drug isn’t super ototoxic, this delivery method is not potent enough to create high concentrations, and this duration just seems...

I know this is an older thread, but the month before my tinnitus I was using topical Clindamycin for a bacterial infection on my neck. I used this for about two weeks, twice a day. Hard to recall, but I believe I had a few signs of tinnitus onset earlier than when I was taking this drug...

I also used a Clindamycin topically for a week or so in Aug 2019. I would be surprised if a topical gel could cause ototoxicity / tinnitus, but then again, who the heck knows. Amoxicillin is not ototoxic, so that isn't a root cause. Hmmm this is a stumper.

I managed to pull my drug history - here's what I took (for what it's worth)... December 2018 - Amoxicillin, a ten day course, I believe it was 125mg course January 2019 - Cephalexin (Keflex) 7 day course at 500mg / day March 2019 - Cephalexin (Keflex) 7 day course at 500mg / day Tinnitus...

Hopeful!

Thanks Deb. You too - we’ll figure it out. Sounds like you’ve done so much from your posts. Funny you mention GABA - Ativan and Xanax definitely help my tinnitus to some degrees. Maybe a link - who knows.

Yes, that’s true. Many have Tinnitus and hearing loss. Dr Tzounopoulos has it, I believe Rauschecker has it, I read somewhere Susan Shore has it... at least it’s good, smart company.

I agree with you. There is a very big market here. HIV now has a ton of prevention drugs, but there’s still a ton of $ going into treatment therapies of chronic cases. It’s easy to worry about drug companies leaving us behind, but there are many people on the field trying to solve, and likely...

Right. There are estimated 50m Tinnitus sufferers worldwide. Not all would seek treatment, maybe 10-15%, which leaves 5-7.5m people that would try a therapy (maybe more? If Regen drugs solve half of those cases, that leaves 2.5-3.75m people that may elect a treatment for chronic tinnitus...

I agree with all of your thoughts. The good news is that there are a ton of people working on therapies. I am also interested in XEN-1101 as a Potassium Channel Opener, like RL-81. I’m not sure what I think about the Hough Ear Pill, but I’m pleased they are at least trying something. 10, 15...

Thanks Deb. Yup, I think it played a part for me too. I have to imagine there was a weakening of my hearing with antibiotics, and then noise set it free.

Thanks Will. I definitely cannot hear 20khz! I assure you of that! At any volume I cannot hear above 13.5khz. Not sure why the audiogram shows that, if so, it’s perhaps just a limit to the test or something.

Here’s my audiology at Tinnitus onset for the up to 8000hz range.

And I can’t really match my tone, but if I play 2700hz I get residual Inhibition. I have a beeping tone at 1000 ish in my right ear. Doesn’t bother me as much.

Hi Will - thanks for relying. 13,500 felt really low too, to me. My audiogram has a little notch. at 2500 or so. Extended Audiogram attached.

They could have weakened them, making the earbuds more effective at letting the tinnitus come through. Impossible to know. I’m just hopeful that the current drug pipeline (Fx322, Pipe505, Oto413) could help me, despite the healthy audiograms. I’d rather not be a unique case with this disease. I...

It could very well be. Or a combination of all of this. I just hope that the hearing drugs in the works can help me, as I don’t have explicit hearing loss.

I should note, the tinnitus didn’t start until about 5 months after the end of the antibiotics courses, and I never had any Tinnitus while on the meds.

I believe they were all Cipro.

Hey there - long time lurker first time poster. Would love opinions: Tinnitus started September 2019. I’m 37 years old, and hit me out of nowhere. Did a steroid course, vitamins, ginkgo, ear wax, chiropractor, acupuncture, dental check. Nothing. My tinnitus is maskable, lighter in the AM...