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If you're going to do Cerebrolysin, you should add in Vinpocetine, Pentoxifylline and Piracetam to it too. Here is a patent from Russia where they use all these compounds: Agent for sensorineural hearing loss treatment (versions)

Someone should tell Dr. Shim to look into intratympanic injections of 7,8-DHF. It restores IHC synapses and increases neurite outgrowth and is very cheap. I literally have some in my draw but no doctor in Australia would dare doing a DIY intratympanic injection lol.

I've been real busy recently but I've pivoted slightly in my approach. I have the Zoledronate ready to go but I've actually found a biotech company that can custom synthesise Risedronate-7,8,DHF conjugate for me which I can take in a pill/capsule form. I'd much rather take a pill that works...

It's actually very easy. AllDayChemist or IndiaMART. No prescription required.

It depends. If your tinnitus is from cochlear synaptopathy and the Bisphosphonates regenerate the IHC afferent synapses then it'll affect your tinnitus whether you have osteoporosis or not. Also my Zoledronic acid arrived today. The preparation begins, I'll need a period of 3-4 days off work so...

Will report back here soon, it has almost arrived at my place. I've read the study you're referring to . Here is another study using Bisphosphonates (Risedronate) and a TRKB agonist (7,8,DHF). They use Risedronate as a delivery method to get the TRKB agonist to the cochlear which increases NT3...

Yes you can. I am going to try Zoledronic acid soon. Going to do 0.5 mg IV infusion. i believe it'll work for my cochlear synaptopathy. Worth a shot. There is no need to use the full dose in my opinion (4 mg or 5 mg) as those are intended for osteoporosis. The reason why systemic administration...

I'll be doing 2 months of Oxytocin therapy soon. Will post results once I'm done with my experiences.

Fair enough. I actually ordered the Cerebrolysin for reason other than tinnitus (ADHD) but have seen others say it could help with tinnitus. I'll see what happens though.

I've been doing some research too and have found out that the compound Mannitol increases absorption of drugs through the blood-labyrinth barrier by a process called osmotic disruption. So that could definitely help with drug delivery to the cochlear. I've got some Cerebrolysin on the way...

Haha sadly you can only administer it via intramuscular injection which turns people off. It's reported to increase BDNF up to 300%. It also increases nerve growth factor. Sadly it's not guaranteed that any of this passes through the blood labyrinth barrier to enter the cochlea. It does help...

The best drug for increasing BDNF is Cerebroslyin. A Peptide noortropic used for healing traumatic brain Injury.

I've had multiple audiograms done and the specialist said they were fine with no damage at all. The thing is I struggle in almost every social situation with background noise. I can't understand people and everyone is mumbling, but when I'm at home lying in bed for example with no noise in the...

I actually have higher hopes for Otonomy's OTO-413 than Frequency Therapeutics' FX-322 to be honest. Otonomy are behind Frequency Therapeutics but there a numerous studies going on with BDNF and neurotrophin-3 growth factors repairing synapses in the cochlear. I have cochlear...

Please let that be true. If they are able to do the pivotal phase without redoing Phase 2, then that's a godsend and saves alot of time.

Do you reckon David Luchinno, Robert Langer and the rest of the team are hurting right now and don't know what to do? Or do you think they know specifically what went wrong and how they are going to fix this?

I still don't understand how WR scores can increase in all groups but it "didn't work". Does anyone know if they have to do Phase 1/2 again to change it from 4 doses to one? Or do they just have to do Phase 2 again? Or best case scenario is FDA allow them to go straight to Phase 3 because...

So I bet you they found this out by people who didn't have that bad of hearing anyway that faked their WR scores to moderate/bad and then they believed they got FX-322 from placebo when they really didn't so then they did the WR tests normally without faking anything. Therefore the trial...

Only 10 more possible days for the 90 day data to be read out. Cmon already, Frequency Therapeutics.

Tomorrow right?

In that case @Diesel, I will just assume it's going to be on the 26th of March now. 17 days ain't that long, 2 and a bit weeks. I am quite excited now and I'm praying they smash this out of the park. Let's go Frequency Therapeutics!

Interesting. Won't they announce the date when they are going to read out the 90 day data? I don't see why they would keep the date a secret lol.

28 days or less now. Yes I am counting.

Happy readout month.

Very annoying news that Otonomy will take even longer now...

I reckon it'll be around $1,000 per week of treatment, split 50/50 between the drug and ENT. The drug is cheap to make but ENTs will definitely want their share. The procedure takes 15 minutes in office so it isn't a huge deal. If you need 4-5 weeks for noticeable change, then they will be...

It's CHIR99021. Wikipedia mentioned Frequency Therapeutics on this page in the past but it seems it has been edited.

Ah I see. I was just going off what Carl LeBel said on the Tinnitus Talk Podcast. He pretty much said Frequency Therapeutics would be doing Phase 3 no matter what. So do you think they'd just scrap it if they got approved? I think it would still be handy for them to have the data.

Frequency Therapeutics are certain on doing the pivotal trial though. Would they even distribute it and sell it if it was approved early?

Exciting but at the same time sort of a reality check for time frames. Pivotal trial in 2022 - Could they start late 2021 though and have it finish in mid 2022? Just like Phase 2 did. If they finish mid - late 2022 and have it ready at the beginning of 2023 then that's 23 months. Seems like...

My tinnitus is definitely hearing loss related. I fell asleep with headphones on loud for 13 hours and woke up with tinnitus and cochlear synaptopathy. I'm more excited for hearing restoration as not understanding speech in noise bugs me much more than my tinnitus does. That being said if it...

I cannot wait to feel the cold steel hit my cochlea! Hurry the F up and approve FX-322 and OTO-413!

I wonder what happens to the dead hair cells in the cochlea once FX-322 is administered? Do the new hair cells replace them or are the dead hair cells still there and the new hair cells are just grown around them? If the new hair cells replace the old ones, then that would be good I think.

Good to hear some positive anecdotal evidence but this just makes me more keen for March and May 2021. We still don't know the doses they are using and it's still only in one ear. The other ear being used as a control. If people are experiencing such a positive response from 1-4 shots of...

So can we now expect to have some results available in March 2021? That is late Q1.

Frequency Therapeutics are really going hard. Legends.

Just my opinion but I reckon they will skip phase 2b and go to phase 3. The countdown to April/May 2021 is on.

For sure that's relieving to hear. If they do a trial in Australia I will sign up for it 100% and I'll do a review of it and post it up here if I get accepted. Obviously after the confidentiality agreement is over. Otherwise I'll be looking to travel to wherever it's available first haha.

Do you have evidence that a portion of the regrown hair cells aren't functional or is your debate based on the fact that they didn't provide the specific details of what you're talking about? Right now everything you've said is speculation and there's more evidence towards the hair cells being...

They are expecting to release their phase 1/2 results in the next 3 months. If their results are good, which it seems like they will be, then they could actually have phase 2 done by June/July next year if they are going quick. Seems like Otonomy and Frequency Therapeutics aren't messing...

Any articles I can read about this? That's pretty big if you think they could beat Frequency Therapeutics. When I check Otonomy's website, it says they are still in phase 1 and that is a fair while away from being available to patients.

For sure that all does make sense. As for treatment availability it seems like hair cell regeneration will be available first before synapse repair though. Guaranteed I'll be getting FX-322 as soon as it comes out and then maybe PIPE-505 when that comes out too.

It would annoy me healing tinnitus and not my hearing loss. Although silence would be good, I want to be able to communicate properly without interference more than anything. I am curious as to how Neuralink would cure tinnitus and could it even repair hearing loss? I guess it would send...

Studies are leaning towards people getting cochlear synaptopathy/synapse damage before they actually lose the inner hair cells. So my question is if you have both hair cell damage and cochlear synaptopathy, which order would be best suited?

So SPI-1005 is just an otoprotective drug after noise exposure?

A good question I reckon is if you have hearing loss that is from both cochlear synaptopathy and the loss of inner hair cells, which order of drug treatment would you have? Repair the synapses first and then regrow more hair cells or regrow more hair cells and then repair synapses afterwards?

Carl LeBel said the phase 3 can take anywhere from 1-3 years. So worst case would be 2024. Praying that isn't the case and the results are good enough to be granted Breakthrough Therapy drug designation. Or that they make it available through the Right to Try laws. The next 6 months are so...

Hough Ear Institute seem to be going much slower than Frequency Therapeutics.

@all to gain All they could do is talk shit on FX-322 and say it doesn't work and people don't get benefits from it. Once the cat's out of the bag they are done. They will still have a fairly large market as hearing aids are needed for congenital hearing loss but the majority of hearing loss is...

@aot I am 25 and suffering pretty bad. I am over not being able to go to bars and restaurants and people mumbling all the time. It will be a good day once we all receive treatment and can enjoy silence.

It probably would come out in 2026-2027 without Fast Track and 2023-2024 with Fast Track.

That's really good news. By June next year we should know a lot more. It's already been fast tracked and there is positive results coming out from the phase 1/2 study. I've seen people mentioning they will attempt to use the Right to Try laws to access FX-322 earlier than usual.

I have been talking to them for a couple weeks. I have sourced peptides from similar biotech companies before for peptides like BPC-157 and it was good quality. Yes, I have read on the Hough Ear Institute's patent that 300 mg/300 mg per kg of body weight of NAC/NPH-07 was used but this was for...

I have found sources for NPH-07 online. All the info you need is on Hough Ear Institute patents which I found while researching. In another study I found the max dose the Hough Ear Institute tested on patients was 1500 mg. https://www.freepatentsonline.com/y2018/0117115.html Here's a source...

Heres where you can buy the drug btw. https://www.alibaba.com/product-detail/NXY-059-Disufenton-sodium-168021-79_60811961857.html?spm=a2700.galleryofferlist.0.0.597972eeX4WfQy

i saw your posts on the hough pill. You can buy the drug from chinese biotech companies. it is very expensive tho i have been looking into making it myself but i am just skeptical on wasting my money as i dont have information on what dosage would be therapeutic. Check out this patent from...

whats up man

Justin, Any chance of your drug being fast tracked like FX-322 was? And how long does fast tracking take off time to hit shelves? Funny, I was just watching a video with you in it explaining the FDA approval process.

@MRItechssuck Nothing will happen with just NAC. Adding NAC to NPH-07 (2,4-DSPBN) has high synergy together but you need (2,4-DSPBN) most importantly.

@GBB, that's 2 patents I've read on cochlear synaptopathy that have said it is the cause of tinnitus and repairing synapses heals tinnitus. I contacted a biotech company about the price of NXY-059 and it is quite expensive. 500 grams is $22,000 USD. You can get NAC really cheap from...