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This was before the disappointing results. From the newest report: “In light of the challenging financing environment, we intend to explore strategic options to advance and realize value from our pipeline including both OTO-413 and OTO-825, our gene therapy program for congenital hearing...

Disagree. There are at least 6 companies working on different hair cell programs right now: Frequency Therapeutics, Otonomy, Decibel Therapeutics, Akouos, Hough Ear Institute and a not disclosed partner working with Astellas. There are also many researchers in universities working on hearing...

The audiogram was not performed inaccurately. The audiogram is a highly inaccurate way of measuring hearing.

I wouldn't worry about it. Just give yourself some time to relax and things should go back to the way it was before you were exposed to these sounds.

You are fine. 50 dB is way too quiet to cause any damage.

You did it again! You throw out big claims with no data to back them up. I would love to take a look at the dozen pre-clinical studies that have completely diminished tinnitus in vivo animal models.

Please show me the data backing up these statements. There are things in the works, yes, but "curable"? "Preventable"? Big words you are throwing around here...

You're right, they removed it... Kudos to whoever archived the web page back in April. https://web.archive.org/web/20220426153740/https://innerear-disorders-therapeutics.com/

I was just referring to NIHL in general. They are definitely not running to the gun range afterwards, but I think the theory Chad presented is plausible.

It's all speculation. These are businesses trying to deliver a product into a market where there are no current therapeutic options. Stop acting entitled.

This is incorrect. Outer hair cells are extremely delicate, and NIHL is indeed caused by exposure to loud noises over time, but also from very loud short sounds such as gunshots. We're not talking tens of years, we're talking seconds, minutes, and hours depending on the sound pressure level.

If it's any consolation, steroids normally help restore some hearing with sudden hearing loss, and sometimes with noise-induced hearing loss. If some hair cells died after the acoustic trauma, they're not going to grow back by getting steroids.

Depending on how precise the measurement is, I'm guessing they could measure objective changes in tinnitus for potential treatments. A pretty amazing tool to be honest.

How is your audiogram? What frequencies does it show hearing loss and how much?

Look up cochlear organoids. It's being used to test these kinds of things.

One of the inclusion criteria was: Subject has audiometrically-defined normal hearing or up to moderately severe hearing impairment. Doesn't mean a person with profound hearing loss wouldn't benefit from it, but maybe someone else knows more.

For any illness or disorder, there will always be heterogeneities in what's causing it.

Fantastic news!

This year has so far brought some interesting developments, and within the next 4 months or so, we are seeing results from at least 3 different trials.

I get the impression that their drugs are well developed already, so surely part of the lay-offs were redundant staff?

Seems like they will present the results from PIPE-505 Phase 1/2a before, or at the Inner Ear Disorders Therapeutics Summit. The event takes place 21 and 22 of June. Source: https://innerear-disorders-therapeutics.com/conference-agenda/day-two/

After a joint research collaboration phase, Boehringer Ingelheim will be responsible for further preclinical and clinical development, and commercialization.

From Boehringer OKs $100M biobucks deal for hearing loss R&D project: Progress has taken longer than originally planned. Otologic talked about getting into the clinic in 2017 when it licensed the technology from Hough and targeted a 2020 start of human studies when it landed the grant funding...

Hough Ear Institute has been working on this for many years. The publications "Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA" and "Regeneration of cochlear hair cells and hearing recovery through Hes1 modulation with siRNA nanoparticles" was...

Huge news. Autigen Announces Collaboration with Boehringer Ingelheim to Discover and Develop Novel Treatments for Hearing Loss

Around 52:00 is what I'm assuming he was referring to. Seems to me like they are talking about gene therapy and not stem cell therapy?

Thank you. Do you have a timestamp?

Do stem cells actually destroy progenitor cells, or did you make this up? Any sources?

I wonder what the difference is between Lineage Cell Therapeutics' and Rinri Therapeutics' approach? Does anyone have any insight?

Here's a quote from the Frequency Therapeutics front page: "Millions are impacted by hearing loss. We're seeking to restore the clarity they've lost." 12 kHz and up plays a somewhat small part in sound and speech clarity, but it is a great start nonetheless. FX-345 has a lot more potential...

You think the first hearing restoration treatment is not marketable?

Doesn't seem like it's even getting tested for tinnitus? How are you going to persuade a doctor to give it to you then? I see you posting in the Sound Pharmaceuticals thread too about SPI-1005. SPI-1005 is being tested for Meniere's, so unless you have tinnitus caused by Meniere's, it will...

It is a bit confusing, I'm hoping they're going to clarify things down the road.

Lineage Announces Pipeline Expansion to Include Auditory Neuronal Cell Therapy for Treatment of Hearing Loss Expansion of Pipeline Into a Third Neuronal Cell Type Builds on Existing Capabilities Intellectual Property Has Been Filed Covering Composition and Methods for Generating Auditory...

Pipeline Therapeutics have changed their "About"-paragraph in their articles from the News-section from: Pipeline’s lead clinical program, PIPE-505, is in an on-going Phase 1/2a study to treat sensorineural hearing loss (SNHL) associated with speech-in-noise disability. The Company also has an...

Pipeline Therapeutics to Present at Upcoming March Investor Conferences They're having a presentation very soon. 32nd Annual Oppenheimer Healthcare Conference Tuesday, March 15th, 2022 at 1:20 pm ET Hopefully, there is some info about PIPE-505 there. I have my suspicions that the results...

That's really disappointing, but thanks for the answer.

Was the removal of the numbing stuff optional? Could it be different depending on what they are using as a numbing agent?

Did they remove the numbing agent afterward? With suction?

That's completely different. The "earwax softening stuff" normally gets washed out during syringing or a normal shower. With an intratympanic injection, you have a hole in your eardrum, and to my understanding, you need to avoid any liquid going into the middle ear until the eardrum heals.

I'm guessing the numbing agent is on the eardrum itself? I can't imagine that any ENT would actually remove a numbing agent from the eardrum with a curette? Sounds unlikely considering the risks. Seems like suction might be the only way.

"We expect Phase 2 clinical trials to begin this year." That was in 2020, does anyone know if the Phase 2 clinical trials were ever started?

I'm guessing the patient could find out after the trial results are published?

Does anyone know if damage to synapses can also affect thresholds? Has there been any research showing this?

New drug treatment hope for hearing loss Seems like a new article?

To my understanding, a theoretical improvement with FX-322 in audiograms would require complete damage to one of the hair cells around the frequency being measured during pure tone testing. Let's say the regrown hair cells are under or over 8 kHz. This should somewhat improve your word...

If these are the only frequencies you can find any hearing loss, then you have great hearing. Don't stress it!

I like the analogies, but they are of course naive and inaccurate. The brain is arguebly one of the most complex things in the universe. The understanding of tinnitus is mostly based around theories, so only the future will tell what actually happens when you restore hearing.

Maybe, maybe not. You are removing the brain from the equation though, but it's just speculation at this point. Hopefully time will tell.

Sadly, it could be a lot more complex than this. In my opinion, the extra gain from hearing aids help mask the tinnitus, just like listening to white noise or music. So not actually reducing it, just frequency masking, which in turn you would experience as a reduction. But maybe someone else...

Yes, this is a part of cochlea repair. There are several companies trying to get drugs to market for this particular issue. There are also many scientists around the world researching the ear to get a better understanding of these things. But to be honest, we don't know if this will solve...

Not really. Seems like certain solutions for regenerating hair cells/cochlea repair are inevitable at this point, so that's more of a when and not an if. But realistically, it could be decades away... Whether it has an effect on tinnitus or not, we don't know yet.

I find it odd that they are not doing any audiogram measurements. I don't think regenerating hair cells for 10 kHz and up would really affect speech perception much. Maybe it would bring some clarity to the sound, but I can't imagine it would be much. Nonetheless, interesting results and could...

Couldn't this be hidden hearing loss be damage to hair cells outside of the tones tested, instead of synaptopathy?

Does FX-345 aim to also fix existing hair cells, or is it mainly to generate new and functional hair cells?

No problem, I get it. At the moment, my tinnitus (in both ears) is more in the background, so it doesn't bother me that much. When I had a spike in that period, it was louder, and much more distracting (causing me to be irritated, and worried that it would be a new baseline). I think the best...

It took a couple of weeks.

Last year I experienced something similar, where I had been exposed to some loud sounds first, and a week or so later I went to the dentist, where they used the same drill (ultrasonic scaling device?). After a few weeks of time, it went back to normal.

Exactly! And I'm not trying to shit on people who have tinnitus and that feels like an alternative treatment has helped them. I have tinnitus myself, and I truly feel bad for everyone who has this awful condition. It fucking sucks.