Search results for query: *

What I see on the site is they "announced" positive data on April 9th, 2019: Frequency Therapeutics Announces Positive Phase 1/2 Data for Drug Candidate for Hearing Restoration For someone who was asking why they couldn't enroll in Q4. I would be rather surprised about this, because if they...

Likely in Q1/2022 if they get FDA approval in Q4/2021. That's my guess.

Folks concerned about recent weakness. It's all part of biotech ETF rebalancing. I confirmed my statement Friday when I made this claim today, XBI added 1.5%, over 520k shares to their existing 345k position to get to 872k shares. I'm sure other institutes were front running and making money...

82 words improved collectively across 6 people. Average improvement is 82/6. Multiple by 2 to get a score improvement (since 50 word test). That gets you 27%. Remove the 4 word improvement 6th patient. Becomes 78 improvement, divide by 5 patients for average word improvement, multiple by 2...

Yep, I basically looked at the average improvement seen in the moderate hearing loss responder population in absolute numbers, then I looked at this with a lens of counting all 6 patients vs counting 5 patients. If I count all 6, you get 82 words improved across 6 people, which amounts to 27%...

It absolutely will be a huge biotech story, and the reason why I'd be happy with even 1% (aside from financial implications) is I view this like a mathematical "existential proof" if you are familiar with the concept. Such proofs are done to prove QED that there exists a solution to a problem...

Wow, I hadn't realized how intensely they blind the studies involved! This is the first trial I've ever encountered with quadruple blinding (participant, care provider, investigator, and even the outcomes assessor). I've literally never encountered this in my time before, most trials stick to...

Cherry picking patients to prove there is a statistically significant difference between placebo and treatment is good science as someone else said. Nothing sinister. All of the trials this year are intended to identify the broadest widest set of participants that will be responders and be...

That makes sense given the hidden WR deficit requirement to participate in the trial. I'm really curious how they use WR deficit, if they use WR quiet or WIN or an average or needs both to have deficit. Very interesting signal, I am unsure if this means no tinnitus participants in study, I...

In my opinion that is why they biased the Phase 1b trial to be 2:1 ratio of mild severity vs moderate severity SNHL. And yeah the stem cell confusion is serious. One of my buddies I discuss biotechs with had the same confusion and he's a very intelligent guy, so the confusion is wide spread...

In Aaron's words copy pasting this from another chat thread we had: "1) Cell fate. Unlike stem cells, progenitor cells have a pre-determined cell "fate". If you watch the video, you learn that half of Will McLean's research was simply figuring out which progenitor cell becomes a hair cell (the...

Your wish is my command. Consider him educated. And yeah the point on KOL talk that they aren't sure about is if damaged hair cells see no benefit but are looking to the trial to inform is interesting, I'm hopeful but setting conservative expectations, though it makes sense to me that some...

Yep I saw that, I agree FWIW with your WR deficit range, based on Raffin table for statistical significance ranges + clinically meaningful I expect WR deficit range minimum is likely between 70-85% minimum, WR deficit needed to be eligible. If they did do long term onset hearing loss criteria in...

I think if Phase 2a succeeds, eventually they can figure out how to penetrate deeper. All we need is confirmation the drug works in a meaningful way. It's a drug delivery problem, not an efficacy problem that prevents lower frequencies. This can be solved. For all we know, Frequency...

Making money would be nice, but I'm here as much for being part of a history defining moment of real clinical stat sig evidence that regenerative medicine is here and possible (with hearing loss benefitting). My dad has a hearing aid and tinnitus and as I've understood the area more I've grown...

For others that want to see what I believe are actual examples of major bets by institutions/potentially insider leak based activity, read the below. The tl;dr is there's people betting millions on FREQ to have not just positive result, but results that warrant price rising into the $70-90 range...

To be clear, sorry I misread what you were saying and want to correct the record again. I consider Market On Close as "after hours" volume because it technically only fills after the trading day has ended and acts as the final trades and executes technically after 4 PM market close...

Thanks. I appreciate the extra info and references to articles. I've been wondering how I could front run this myself as a retail investor if I wanted to (not based on insider information but predicting it in advance or watching tickers live). I certainly know my FREQ shares would feel lighter...

Yeah I mention this on the Twitter thread, that this is the crux of bull vs bear. Phase 1 trial was murky as not powered or intended for efficacy, it was a lucky side effect for a safety trial. Bulls see the data and believe this is true indication that drug works, hence Phase 2a if designed...

I'm not sure you know what you are talking about. If an order fills on the ask price, that is de facto a buy, not a sell... There was no 500,000 share transaction in regular hours. There was a lot of volume the last 15 minutes which totaled around 530,000 volume, through thousands of shares...

The only issue is we have no data of placebo patients that match the characteristics of those responders unfortunately (baseline scores etc), hence you can model the FX-322 groups potentially (though extrapolating multi-dose would be speculation imo given lack of data), but you can't model the...

20Q: Word Recognition Testing - Let's Just Agree to do it Right! You use the chart on this by looking at baseline score and looking at range for 50w or 25w test to determine if new score is stat sig change. The 6% or 3 word isn't a std dev AIUI, it's the expected variance if you test and...

Yep, that's accurate and my understanding. The entire reason for priority dates is to act as a method of marking when you have approached the patent organizations that support filing claims, and made "public" (I'll explain why in quotes) your IP or concept that you want to claim is your...

New to Tinnitus Talk, here mainly because I've gotten into Frequency Therapeutics in sheer excitement at their potential to offer hearing loss improvements (dad suffers from a bit of tinnitus as well as has a hearing aid). The patent data mentioned is really interesting. That data point of the...