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I don’t recommend that you do any of those “treatments” I mentioned in previous posts alone.

It can be both. This study indicates that it is due to inflammation: https://news.arizona.edu/story/brain-inflammation-identified-potential-target-treat-tinnitus

Most people grow it themselves. This is a course on how.

It is insanely expensive, and unlikely to have an effect on neuroinflammation unless injected directly in the spine. It doesn't cross the blood brain barrier otherwise. Psilocybin does block TNFa and crosses the blood brain barrier and it is practically free.

Yes. MUCH safer. Overusing steroids can lead to bone death, particularly the leg bones. I know someone who got desperate to make their cluster headaches stop, and overused steroids. They had to have double hip replacements. With Psilocybin, there is no physical risk anywhere close to that. I...

Truffles are very weak in comparison to mushrooms, so you would have to eat a lot more each time to get the same effect. Per gram, mushrooms contain roughly 10 times more Psilocybin than truffles. It will be cheaper to grow it for yourself in these quantities. I wouldn’t start the process...

Control The Experience. I suggest you focus on learning cues and techniques for managing the trip. Learn some “rescue” techniques on what to do if you become uncomfortable. Don’t forget that there are “rescue techniques”. With the use of VR headsets as one of the redirecting tools, the...

I stand corrected. I assumed that the term just meant reacted to sound in general.

I was a guinea pig for the Psilocybin part, but not exactly microdosing. Psilocybin Stopped the Ringing in My Ears

I think that they will have great results. The effects of 5ht2a agonism and inflammation are well documented. They can look at dozens of different inflammatory diseases, the mechanism is the same. Antioxidants? Sure. They are good for you. Destress, eat healthy, yadda yadda. But taking some...

I did something like this under the influence of psilocybin, and it was EXTREMELY effective. After my attention wandered, I eventually couldn’t even find the sound again.

Steroids are effective, but they cannot be used long term. Even using Psilocybin requires regular dosing. If I had been using steroids at this frequency over the past year, I would be due for a double hip replacement.

Be careful about jumping to conclusions about anything regarding plasma levels. TONS of medications can reduce TNF in plasma. That is just blood. The tissue they need to target can technically only be tested upon autopsy. Maybe a spinal tap could give some info, but it wouldn’t be necessarily...

Did you read the article I posted above about neurodegenerative disease and TNFa? Between that and the one about Enbrel, it should be pretty clear that we are not talking about inflammation limited to blood vessels.

This paper does a good job of explaining why biologics don't help neuroinflammation: Neuroinflammation as a Common Feature of Neurodegenerative Disorders Keep in mind that it is old, FYI. I'm not sure what happened with the new interest in Thalidomide.

It does reduce inflammation in the ear. I think it can have a significant effect on neuroinflammation too. But it is temporary, and not suitable for long-term use. I know a guy who was so desperate, he overused steroids until he actually suffered bone death in his hips and had to have both...

The molecules in TNF blocker medications don't cross the barrier, so no. They do not address neuroinflammation in a significant manner. You can read the article below about Pfizer's kerfuffle with Enbrel. It is speaking about neuroinflammation in relation to Alzheimer's, but keep in mind that...

Something pretty important to note is that those medications do not cross the blood/brain barrier. They have little to no effect on the neuroinflammation associated with tinnitus. This is part of the reason Pfizer probably declined to investigate the biologic Enbrel for Alzheimer’s. It had some...

I don’t understand what you mean here. You have been on TNF blockers? Like a biologic?

@Lukee, this is what I was mentioning.

Yeah, I was too quick on the trigger. And I couldn't figure out how to delete. I apologize. TNFa blocking may play a part in the resolution of my headache. I was reading this article and was overly excited: Brain Inflammation Identified as Potential Target to Treat Tinnitus @Lukee, This...

This is 100% what happens during my mushroom sessions. I can control the sound, summoning it and changing it at will. It is mesmerizing, right? I had to take multiple doses, and after practice that control extends to "sober" times too.

I might be able to shed some light here. Look into the "Entropic Brain Hypothesis". The idea is that being under the influence causes very disordered brain activity. It is the equivalent of pulling everything out of your drawers and off the hangers in order to organize your closet. You make a...

I'm not sure where you got this info, but both Psilocybin and LSD work on 5ht2a. Both have very strong anti-inflammatory properties and reduce TNFα, IL-6 and IL-2. The psychoactive properties of LSD are just longer lasting.

I thought all tinnitus was reactive? Loud places or certain sounds make it worse. Especially if you transition to complete silence after.

Yes, the "full of water feeling" resolved. That side of my head still feels different from the other in a way that is difficult to explain, but it is not really painful anymore at all.

Wow, what were you having it done for if you don't mind me asking? Do you have a pain condition like CRPS?

I think it would work regardless. The people with nerve pain from an amputation had severe trauma, and using psychedelics is effective for that. They are using psychedelics to reinterpret the signals from damaged nerves.

Psilocybin would be safer.

This is exactly how Psilocybin with mirror therapy works for phantom limb pain.

I think I can give some insight on how/why drugs with psychedelic properties seem to worsen tinnitus. I use Psilocybin, another substance that causes visual and auditory hallucinations. While not unpleasant, it did make my tinnitus much louder during the sessions. I was using it to treat a pain...

I have actually never had an audiogram done. I did have an ENT examine my ear back when it started, but they did not see anything physically wrong with my ear. Refractory hemicrania continua is a tough situation. To be honest, I was not interested in pursuing remedies for tinnitus back then. I...

@G H, the doses were quite high. 5 grams each, 5 days apart. @Lukee, I did make it very clear that the text was from an article I wrote for my site. Most of the stories here about Psilocybin are in line with my experience. It causes other auditory hallucinations and exacerbates tinnitus. But...

My tinnitus faded away after using another psychedelic, Psilocybin. I bet that Ketamine would have a similar effect, but you would probably have to do the inpatient loading dose that they do for chronic pain patients. I doubt that the little doses they do for depression would have much of an...

This is copied from an article of mine. I own it, I wrote it, it is MY story. Neurological Issues Caused My Tinnitus This is a personal story. Dosing with Psilocybin for tinnitus worked wonders for me. The ringing in my ear was related to my headache condition, hemicrania continua. This type of...

@Lukee, is it completely gone? That's a tough question. If I am in a completely silent room, I can recall it if I concentrate hard enough. But if my attention wanders, it is gone again. When I meditate, I recall it on purpose and use it for meditation. I know that may sound nuts to you, but I...

My experience is in line with @Amy Rosenthal. I took a series of large Psilocybin doses to manage an intractable headache condition. In the process, it also cleared up my tinnitus. But there are some things to keep in mind: - The DIRECT effects of Psilocybin include auditory hallucinations...