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Well, good luck trying to sell their failed drug. Tesla open sources tech and algorithms (that are probably worth more than everything Frequency Therapeutics has combined) because they have confidence so they don't give a shit. Reminds me of the "ahh but people will steal my brilliant idea!"...

Why don't Frequency Therapeutics have the decency of at least open sourcing FX-322? That IP is worth shit. At least let other labs try it. I guess they also failed on the ethics trials.

Seems like this study has some really weird pseudo-science paragraphs though, not sure if it is trustworthy: Interesting, how do you know? I thought it was private info?

You do realize that Clonazepam (and other psychoactive drugs) would also greatly reduce the pain inflicted by a knife stuck in your arm, right? You can't just make the jump from "this psychoactive drug solved the issue" to "this is not a physical problem". Note that the cochlea has hair cells...

Are you aware of Nano MRI? If I'm not mistaken (and chances are I am), some labs are using targeted contrast (i.e., small molecules that target specific cells via viral vectors, for example), in conjunction with high resolution MRI, to image cellular scale structures in vivo. Can someone explain...

Quick disclaimer: I'm a software engineer, not a biologist, so, by all means, I'm a lawman, this post comes from an admittedly ignorant point of view, which I'm willing to change. Yet, regardless, I think I have the right to have concerns, and, as such, I'll do my best to write a high-quality...

I mean, if you are so certain it is scam, it might be. My point is that 4 failed treatments do not imply that the idea is necessarily bad. That's not how stats work. You seem to have a bunch of additional reasons to believe it is a scam after having visited the clinic, which, fine, I can't...

I mean, I do understand your frustration and don't think it is unjustified. But calling the clinic a scam is a strong accusation, that one shouldn't make without conclusive evidence. Moreover, the method itself could still have value even if it turns out the clinic is not legit. The things I...

Calling the clinic a scam is as extremist and unproductive as claiming it has a cure. No, we can not jump to conclusions because 5 members here didn't get any relief. Just statistically alone, it could be explained by bad luck. The chance is really small (about 0.003%), but it is still possible...

That's what I want most. We aren't curing shit if we can't see what is going on. This is especially important, because if there is no hair cell damage, then you know ear treatments won't work for you. And it will also help us better understand the problem and ultimately solve it. I wonder how...

Went higher, went lower... definitely sounds like it had no effect at all to me, sadly. Sighs. I wonder if we have any report from FX-322 on someone with tinnitus...

Didn't @undecided ultimately say it did nothing to his tinnitus and that it was a waste of money, and that he wouldn't do it again? I may be misremembering. This thread is huge and we can't download it...

See, that's the problem right there. There are observable changes in the brain from playing guitar every day. Or learning a new language. Or getting married. Anything significant changes our brain. That's how it works, neurons are very plastic, that's how we learn, remember and change. Of course...

Okay, at this point I don't think stem cells are worth it. I've browsed quite many pages of this thread and I still couldn't find these people that supposedly got better after stem cell treatment. I've found one person that claimed it did nothing to him, and another person, the thread creator...

Thanks for asking. I'm managing to sleep, which was my main worry, so, yes, things have improved. That said, the tinnitus is still the same. No idea what happened to me that day. Very scary and frustrating.

Yes, I know. I will...

I've been feeling dizzy on my bed in the last ~5 days, so I guess yes, but it isn't very strongly noticeable since I don't walk around a lot. I spend 95% of the day lying down, using the notebook, playing, coding, etc. The thing is, if the cause of my current tinnitus was Meniere's, why did it...

It has been 2 weeks, and I don't have any acoustic trauma though. I just went to a clinic and had an ultrasound dental cleaning procedure. So, is the ultrasound capable of harming my hair cells? Because most doctors said that it is just not possible. So far, my tinnitus has no logical...

Yes, I hear high-pitched (~15000 Hz) tinnitus 24/7. My tinnitus started after a dental cleaning procedure. I just noticed that, when I speak, I can hear these high pitched, very quick spikes. Also, my tinnitus is really weird right now; it is on for 1 second, off for 1 second, repeat. It isn't...

When I speak, I can hear a high-pitched, distorted, metallic screech on the back of my head. It is hard to explain what it sounds like, but it is as if you were rubbing grains of sand on an iron pan. It seems to be located behind my mouth, and it follows the rhythm of my speech. Since I've...

Thanks everyone for the information. Seems like just accepting my current state and adapting to it is the best I can do. Although I'm really interested in at least trying stem cell therapy, as it does look like something that has very high odds of improving my tinnitus, if not other aspects of...

I can tell you with absolute certainty that my tinnitus isn't caused by anything related to sound. I never listened to music and I spent most of the day in absolute silence. Sadly, I contacted the few HBOT clinics around my city. They denied treating me. I will be out of the 2 weeks opportunity...

I see, thank you. It seems like the biggest flaw here is that the vast majority of studies cited don't have a control group, so, while they generally show positive benefits of HBOT in the first 2 weeks, it could be just signaling that people with 2 weeks of tinnitus are prone to recovery...

I got tinnitus 8 days ago. Can someone please point me to the source of the claim that HBOT can be helpful in the early days?

Hey guys, I think I'm doing stem cell treatment. From all I've researched, seems like it is a very harmless treatment that can have good health outcomes regardless of the tinnitus, so, why not. But I'm not confident on StemCells21 being legit. The Energetic Scan thing is ridiculous. They look...

Thanks for the extensive post. I just want to make sure I don't lose an opportunity window for some treatments, but I do feel like the best action would be to just wait and adapt.

Perhaps I'm being extremely dumb here, but aren't we debating whether damaged hair cells stop sending signals to the brain, or if they instead send a 24/7 signal? Couldn't that question be easily answered by simply measuring the nerve fibers that come out of the hair cells? I mean, specifically...

How is that still unknown, though? How hard should it be to just measure the output of the auditory nerve and check if it is continuously sending a signal or just turned off?

Hello everyone. I've completed 1 week of hell, aka tinnitus. It started after an ultrasonic dental cleaning procedure, where I momentarily hurt my jaw, which may or may not be related. I do not have TMJ. I had COVID-19 4 months ago. My tinnitus is a high-pitched (14800 Hz) tone that is up 24/7...

On that topic, is there any evidence the cause is the lack of input, rather than a continuous input?

So stem cells are the only treatment other than FX-322 with actual effects on tinnitus volume? Doesn't that support the hypothesis that the stem cells actually do travel to the cochlea and differentiate into hair cells, rather than just their secretomes being used for healing (which tbh sounds...

Thanks for the comprehensive writeup. Is there any way for people to have access to FX-322, under their own risk? If no, what is the earliest they could get access to it? Is the chemical structure of FX-322 known?

Hello. This thread is *huge*. Can someone summarize the results? How many here went to do the treatment? What were the outcomes?

That clears a lot of things up, thank you for the answer. If I may, one final question would be, then: why would it fail, then? If I recall correctly, the Phase 2 failed to achieve statistically significant results. Does that mean that, for some reason, the hair cells didn't grow in that...

Thanks for the clarification. Do we know how these synaptic connections form? And does that mean that, after therapy, the patient will end up with a bunch of damaged dead-weight hair cells grouped together with these brand new hair cells, competing for space? Hair cells are "carried" by...

Cochlear implants send electric signals directly to the nerves underneath, though, no? So they don't need these nerves to reconnect, they could just brute-force a current strong enough to get there. Regardless, I have no idea what I'm talking about, I'm just trying to understand. So, I'd...

Yes but regardless, if there was any improvement in their trial (the 10% they claim), then somehow it worked. But that sounds physically impossible. How could it have helped if there are no synaptic connections? Is the data just wrong? What really is going on here? This sounds so sketchy.

Can someone elaborate on that? If only hair cells are restored, but the synapses aren't connected to the nerves/brain, then how is that helpful? Won't these hair cells be dead weight?

I am not suicidal! I'm just browsing random threads. I don't even know what thread you're talking about. I'm in Rio de Janeiro. Isn't Prednisone very aggressive and insomnia inducing? I think it would be totally doable to cope with this if I could just sleep normally. Should I just keep...

4 days ago, I had a dental cleaning procedure. That night, out of nowhere, I woke up 3AM with a loud ringing sound on my head. It isn't located in any side. It is high-pitched (14500 Hz?) and continuous. Since then, I'm not able to sleep. It has been 4 days without sleep. When I do manage to...