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@MatthewR, I'll tell you that you'll slowly start to begin remembering who you were again. Yes, it will take a long time (talking years here) but it will happen. There is definitely a lot of hope for you to recover. I remember my acoustic trauma and felt dead inside as all the doctors I went to...

Hi all, I wanted to post an update since it's been about 10 months since my acoustic trauma last year. I've kind of dropped off the forum in the last 6 or so months with the disasters that were FX-322 and OTO-413. I've been doing better recently, my multi-tonal tinnitus (ringing, static...

Here's a couple more pics of the cat, now that he's gotten comfortable.

A little something I found about BDNF: it appears that an over abundance of it causes epilepsy and toxic neuron excitability in the brain. Multiple studies from the below link indicate it. I was against the increased dosage that Otonomy decided to roll with for the last trial. Might have had a...

This followed the same footsteps as Otonomy, multiple dosing one week after the next, whereas Otonomy tripled the amount of gel/BDNF. I still wish they'd release the best responders and give insight into their diet, exercise routine, and other 'odd' tidbits of their lifestyle, like if they...

My bottle of Bragg's ACV was running low so I added about 3 swigs instead of the normal 1. I saw a slight decrease in my tinnitus. I've been increasing the dosage in my smoothie. Maybe a slight drop in tinnitus, but my mood is better and I have more energy.

I've had the acid pain straight for the last seven months and swelling in my middle ear as my ear heals. I'm hoping it goes away by the end of the year since that would be 18 months from the date of my trauma. I'm tired of the pain and having to take Tramadol for it, among other drugs. I sleep...

I did :)

Dexamethasone injections cost $300 near me and that's for the uninsured. I figure the FX-322 procedure's cost would be similar though the amount of gel being injected is far less (0.2 milliliters I believe is the dose they are still using, Dexamethasone injections are 1.0 ml a pop). I'm trying...

I hope someone buys their IP at dirt cheap and can use the savings to put into more trials/development. One thing I always wondered about the best respondents on the successful 0.3mg April Phase2A trial from last year is their lifestyle. I'd love to know about their diet, supplement intake...

Doing better - consistent swelling and dull pain, but my hearing in my bad ear improves just a tiny bit each time it subsides. Give it time

I never invested in OTIC other than being personally hopeful like we all were, but I'm starting to think that even if their latest trial was successful, they'd still go down the same path and liquidate. I feel that was their goal from the get go to try and raise their share value without...

Sleeping 10 hours a night (w/ a cigarette break at 4am) while having an ear plug in is the best part of my day. Ready for long, dark winter.

Good article and find! I guess less is more in regards to dosage amounts/frequency with both FX-322 and OTO-413. -------- -------- Hope this comes to fruition next year, Phase 3 potential. Crossing my fingers. This looks to surely hit the market before (if ever) OTO-413 makes it. I guess we...

Yay, it happened :) Looks like the OTIC stock was a pump and dump short squeeze, but happy to have the offer go through. Syncona Limited Portfolio Company Successfully Completes Tender Offer and Acquisition of Applied Genetic Technologies Corporation (yahoo.com)

LOL, yes easily. Throw in perfect hearing and I'll be indebted to the man for life. Maybe this Neuralink can block the pain signals from the ear, or anywhere selected. Maybe even give everyone the ability to have CIP, the congenital insensitivity to pain.

For my recent MRI, these are the ones that they gave me. NRR of 29, I would have preferred my Macks at NRR of 32 but wasn't allowed to wear them. But really I was more concerned with the contrast dye gadolinium. That made me sick/dizzy for the next few days, and I could feel it burning as they...

Possibly Syncona. Syncona acquiring AGTC (Applied Genetic Technologies Corporation) who is in partnership with Otonomy because of their gene therapy research might be interested in Frequency Therapeutics too. You can read more about them here. They seem to be focused on finding diamonds in the...

This world is sickland.

Yeah, mine is constantly swollen/full. I had an MRI yesterday focusing on this area, and am waiting to hear back the results for it. I might look into the balloon dilation or having a small tube inserted into the middle ear through the eardrum to alleviate air pressure and drainage. Problem...

You know it. Healing and dealing, very nice way to put it. Might try this LLLT and HBOT shortly. I love this activity and effort you put into this thread. I feel @Brian Newman might be interested if these techniques increase myelination of nerves in the cochlea. @Brian Newman, see this below, I...

I've been taking L-Threonate Magnesium - and many other supplements - and have started to think that this isn't a good idea. I'm thinking I should try and minimize my supplement intake and focus on just a decent diet and getting lots of sleep/exercise. I've been taking 2000 mg of the Magnesium...

Your outer hair cells could be damaged and the ones around the 2 kHz pitch are amplifying incorrectly and so are amplifying sound to the incorrect inner hair cells. I think part of my tinnitus is like that since it isn't a stable 4 kHz ring but alternating similar pitches that randomly change...

You're welcome! He had another one too, much more recent (last month) but it is pretty similar to the older video:

Yeah, I should have just said FX-322, I mixed them up.

It had never occurred to me why my dog hid in my closet specifically during 4th of July - I realized it was farthest away from the backyard when we were setting off fireworks to celebrate. I feel so horrible for him since dogs have much more sensitive hearing, birds too but they can at least...

I would LOVE to hear Dr. Charles Liberman on Tinnitus Talk Podcast about synaptopathy induced tinnitus, and he recently was awarded a Grand Prize by the French La Fondation Pour l'Audition, one of the highest honors given in hearing science. He gave a great speech recently there too last month...

Thanks @10Kcd - Success stories are a good reason to keep hope ups and visiting this site. There was this one guy, @Tom 2020, whom I read his story and his ears returned to 85% normal, so it gives me hope that whenever the ENT says, hearing loss is permanent - I don't necessarily buy that. I...

I decided to keep my router next to my laptop and ordered a couple EMF shields to surround it. I de-acted the WiFi on my router and laptop and will only used wired ethernet. Secondly, I bought an EMF poncho which I will use in the coming winter and also to sleep with it wrapping my head, since I...

Cochlear hydrops only affects the auditory system and not the semi-circular canals for balancing, correct? Maybe after FX-322 hits (and FX-345 after that), Frequency Therapeutics would come out with a FX-368 (? - I don't know their naming nomenclature) for full cochlear coverage. To be honest, I...

My NutriBullet is so loud. I have to wear double protection and turn my bad ear away from it. Has to be over 100 dB. It figures I would end up owning one of the loudest blenders on the market. Even before my ear issues, I'd still wear earmuffs when using it. If you all know of a quieter, but...

It seems they care more about speech recognition but tinnitus is listed as a secondary outcome measure. They are only looking at 25 self-reported answers instead of asking the full 142 enrollees, I assume more than 25 in the trial have tinnitus though so I don't get that. I know FX-322 only...

I woke up this morning, with my melody playing. I take my meds and it dissipates... Is my brain holding me hostage w/ T to feed it its fix?

Interesting. Very interesting. Unless she knows a cure we don't have yet available in public domain or has extremely resilient ears, I don't get how she can keep exposing her ears to noises of mass destruction - even impulse noises my gosh. I also wonder if Elon did those noisy stunts with her...

I view it positively. The winter darkness will help me sleep better, the only thing I enjoy doing now. I feel a gut punch every time I wake up.

Just bought Function and Dysfunction of the Cochlea: From Mechanisms to Potential Therapies (Perspectives CSHL), will make for a fun Nov.

Yes, you will see improvement, but not to the extent of those with moderate, moderately-severe, severe, and profound hearing loss since they have more to gain. Even me, who doesn't have much hearing loss would gain much from the extended frequencies since that's what makes up a good chunk of my...

Being brutally honest, as someone who has an orchestra in my left year, it's better for you to stay in computer science. If you want to become a pilot, wait a while for actual cures (with a plural) in the next 10 years (i.e. follow this forum for the next decade), and play the Flight Simulator...