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The FDA is cutting staff and losing reputable researchers left and right. The top vaccine researcher just resigned because the head of the agency literally believes in discredited pseudoscience and is pushing the FDA to adopt it. The person in charge is an anti-vaxxer and the kind of person who...

It is sad that this is receiving funding.

I really wish there were more research on this. There could be potential consequences for those who experience these attacks frequently, which might lead to a better understanding of tinnitus.

Anyone who believes RFK Jr. is a positive influence on HHS or that gutting NIH research, including limiting the G&A rate of university grants that support labs of all kinds, bodes well for tinnitus research is not only wrong but severely misinformed. Or maybe they have a brain worm. I invite...

It's really bad. I think we have to seriously consider that the U.S. will no longer be the first country to produce a Susan Shore device.

No, Mirtazapine helped me settle my sleep schedule. I am about four months in. The biggest issue has been craving sweets and gaining a bit of weight, but overall, it has been completely worth it. No increase in perception due to Mirtazapine.

Exclusive: FDA staff reviewing Musk’s Neuralink were included in DOGE employee firings, sources say Yeah, it’s a no from me, dawg. Real-life Lex Luthor.

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Oh, great. A tool for a tinnitus sufferer, likely already borderline OCD because of their condition -- to further obsess over :D

It would just be a data point—an expensive one that an insurance company is unlikely to cover unless a clear benefit can be identified.

I would like to request that Tinnitus Quest interview/reach out to Dr. Kelly Assouly and/or Dr. Matthew Carlson regarding the efficacy of extracochlear devices. In fact, together, would be absolutely insane although unlikely with how busy they are. Dr. Carlson has previously published on the...

9-10 paragraphs of baseless speculation. You have no idea what is required/what the FDA will or will not do. Great. I can't wait for next week's iteration of the same.

I genuinely think this route has a less complicated and better/less invasive approach, likely with greater efficacy than the current SSD (though I do believe if the Susan Shore Device is refined in the future, it may yield even better results.) I believe the "why it works" could be researched...

Based on what? You have no idea if the device has even been submitted, or if any communication between Auricle and the FDA has occurred. Much like the several last pages, there is a bunch of wild speculation with no basis. Maybe that guy six months ago was right, and the thread should just be...

Reversing Cochlear Nucleus Maladaptive Plasticity via Customized Extracochlear Stimulation This now puts multiple entities trialing electrical stimulation devices: Dr. Carlson at Mayo Clinic (2022) Dr. Assouly w/ Cochlear Ltd (2024, with this likely being the research backing the likely...

Medical devices, particularly those involving surgery or treatments targeting the brain, take time to develop for good reason. Without proper safeguards, people with severe tinnitus might resort to dangerous measures, such as using car jumper cables to shock their DCN, or buying devices that...

You seem more concerned about a test being used to discredit the severity of symptoms, which may be subjective. While subjective symptoms are important in their own right, that is not the primary point of having an objective measure for tinnitus. Consider a car accident that causes tinnitus...

Go look at PubMed or any research repository. There are thousands of studies on whether “breathing farts,” or its equivalent, is better than CBT therapy (talking at you without really doing anything). These studies almost always use the Tinnitus Handicap Inventory (THI) or some variation to...

Yeah, that sucks for those of you who got duped. But spending thousands more just to find out—after possibly fighting a lengthy legal battle—that the LLC has no assets to secure a judgment from? That’s bordering on insanity, unless you’ve got monopoly money to spare.

A few centuries ago, people believed the plague was a response to rampant sin and even resorted to beating themselves in atonement. While we have made significant progress since then, there is still much to learn and achieve. The fact is that everything you hear results from the amplification...

This is not a cochlear implant in the sense that it would irreparably damage the cochlea. Therefore, in theory, it would not affect existing hearing. Typically, a cochlear implant destroys most, if not all, residual hearing and is contraindicated for individuals with normal auditory thresholds...

No updates are available. The status is currently listed as “Not yet recruiting.”

Have you considered he's paying attention because he's literally from France and that is where Cilcare is?

It has not been successfully identified, and potential treatments that showed promise in animal models have failed to work in human studies so far. At this point, there is only theory.

It's a startup partnered with a university. It is what it is.

The simple answer is usually the correct one: they have no way of knowing or predicting a specific date because the FDA certification process is arduous and unpredictable. Think about it. Why would a CEO offer a deadline they know is unreliable? Even if they provided a conservative, arbitrary...

So sound therapy. Woof.

Anyone making predictions before, during, or shortly after the projected (not actual) start of the FDA submission process was already engaging in wishful thinking. Susan Shore has no involvement in the business side or the approval process. At most, she might advise on FDA comments during the...

I think you can still frame the experience as positive if you approach it with the understanding that it might not help. Even so, it’s worth trying, as it could be valuable if a future treatment becomes available. Spending money on your well-being is easier to view positively than simply losing...

I want to reiterate that I think the value of CBT lies in its similarity to virtually any form of therapy: it provides an opportunity to talk with someone who can empathize with what you’re going through while helping you process and adapt to tinnitus. A good therapist, in my opinion, would be...

I am pretty sure my tinnitus is at a high frequency, much higher than what hearing aids can produce. For example, when I drop an Allen wrench on a tile or solid floor, the resulting reverberation creates a very temporary residual inhibition for me. This effect lasts only as long as the noise...

In academia, it is not hard to gain credit on a paper, especially if you are well-recognized and your name alone lends legitimacy and respect to a publication. I see Dr. Shore’s involvement more as advisory rather than something she is deeply pursuing. Given her expertise and academic...

The technique has already been developed and would almost certainly be performed under sedation. It has also been successfully replicated on cadavers.

I am beginning to understand that my primary issue is not necessarily the fluctuation of my tinnitus (though it does fluctuate) but its intrusiveness. When I am more aware of it, I find it more bothersome, but this awareness seems to happen subconsciously. Stress plays a role, of course, but the...

I think the value of any intervention depends on who is providing it, the severity of the sufferer’s condition, and having realistic expectations. For most nonsevere cases, the value often lies in meaningful communication with someone who truly understands the condition, and that can vary...

58.4 ± 13.9 to 46.3 ± 17.5.

Is there no issue with the 25% increase in variance in group NT? It feels like the reduction, when accounting for the additional variance, resembles the placebo group more closely. This leaves only the VP group, which I’ll reserve judgment on until I can review the full paper.

So, group NT shifted from a baseline of barely severe to moderate, +/- basically the entire range between moderate/severe? This feels like I'm looking at CBT-style results. Despite how this report will almost certainly be marketed, it offers anything but evidence that “migraine” is the...

https://pubmed.ncbi.nlm.nih.gov/39559082/ I mean, there is. If you look at any tinnitus research, it’s likely to cite Dr. Shore et al. from numerous studies. However, the tools for treatment aren’t well defined, and even if researchers agree on certain points, there’s little that can be done...

My Eustachian tubes are still no better than they were before the tuboplasty. I hear them close more loudly than before the procedure, but I still experience ear fullness and pressure, even from something as simple as driving. I believe this issue is related to acoustic shock disorder. I also...

I suppose there might be some hope for identifying a marker, but it’s hard to say that I see any promise of reversibility through this avenue of research.

I think it would be beneficial if the study focused on the use of EEG or fMRI, rather than just subjective measures of tinnitus reduction. For example, what changes are occurring in the brain during stimulation? While studies have shown that cochlear implants can reduce or even silence tinnitus...

https://www.advancedotology.org/en/tinnitus-suppression-with-electrical-stimulation-at-the-most-basal-contact-of-the-cochlear-implant-electrode-as-a-model-for-round-window-stimulation-163895 This topic was briefly discussed during Tinnitus Quest Q&A sessions and other events. Dr. Djalilian...

I just wanted to say thank you for the Q&A! Unfortunately, some of the recent events have been scheduled at times when, with young kids, I haven’t been able to participate. However, it’s fantastic to have access to the recordings and to know there are people actively working toward a solution...

This is pretty cool, but it’s probably not something that will be commercially available this decade. I’m curious whether success in this area could help determine if CNS hyperactivity or dysfunction—when tinnitus is the only symptom—might improve with enhanced neural function. Alternatively...

It’s pretty wild when I hear recreations of various tinnitus sounds. It’s somewhat reassuring since very few of us experience the typical single tone that most people imagine when they think of tinnitus. Instead, there’s often a blend of sounds like conflagrations or wave-like distortions that...

Hi everyone. I’ve been having a rough few days. I know things have been left a bit up in the air, but are there any upcoming studies aimed at advancing this research? Like many of you, I’m genuinely excited about potential treatments that address the physiological basis of tinnitus rather than...

Hey @Hazel, I know you're likely busy with life and everything, but I was wondering if you could share a sentence or two about any promising news that might be coming from Tinnitus Quest in the near future?

2026 seems realistic.

Is 4 points a big deal?

I’m assuming it’s when a sound occurs and the tinnitus diminishes. Mine does this when I drop an Allen wrench on a tile. My tinnitus goes away completely for about half a second, then comes back.

I’d like to know if, since the clinical trial includes participants with normal hearing, the implant is expected to affect any residual hearing. I wouldn’t want to participate if it might destroy residual hearing, and it’s unclear whether this is a cochlear implant or another type that isn’t...

If any Dutch speakers could help inquire, I’d be very grateful—I’m extremely curious whether the implant destroys residual hearing. The criteria for joining the study suggest it might not, but my attempt with Google Translate in Dutch seems to have been ignored.

Some of these studies have unrealistic parameters, though it’s understandable to a degree. For example, excluding anyone with depression or anxiety is unrealistic, as severe sufferers are more prone to these conditions simply because it’s a difficult experience. Parameters like “idiopathic only”...

Your advice that they shouldn’t see a psychiatrist, especially at the recommendation of their ENT, is irresponsible and should be moderated or removed from this website. Even if a psychiatrist cannot directly address auditory hallucinations, they can certainly help manage the depression and/or...

To effectively study treatment outcomes, an objective standard of measurement is essential. Take CBT as an example. A new patient’s Tinnitus Handicap Index might be assessed at both the beginning and end of treatment. The Tinnitus Handicap Index, however, is subjective, and it could naturally...

Competition is beneficial. Ideally, we’d see multiple devices undergoing concurrent studies, rather than the current trend where one device fails and all similar variants disappear. I was encouraged to see a major player taking interest. If the research yields positive results, it could attract...

Evaluating How a Tinnitus Implant Affects Tinnitus Loudness in Adults with Chronic Tinnitus and Varying Levels of Hearing Loss It looks like this clinical trial was posted 2 weeks ago. The study mentions cochlear implants, but I’m not sure if there’s a specific placement for this device that...

Virtual Reality and Subjective Tinnitus (ReVA2) This one seems like hot garbage to me; a form of CBT that would just be a waste of time.

Lenire and Dr. Shore's devices are not the same. Dr. Shore’s device relies on the precise timing of electrical impulses, developed through years of research, to attenuate specific aspects of the dorsal cochlear nucleus.