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thanks, i never understood this, let's see what happens

i would like to know if they continued to monitor their experimental rats. if i were a scientist i would have done exactly that. i'm betting those cured rats stayed cured and didn't need re-dosing. it kind of makes intuitive sense that if you've had tinnitus for decades you might need longer...

potassium channel openers work specifically to correct hyperactivity at the neuronal source, as indicated for epilepsy. hopefully this applies to tinnitus, irrespective of age or condition chronicity, even possibly any etiology! i love the fact that the 00063 trial is going to be short, just 4...

maybe we'll all be reading these words for real soon

this is very interesting. you'd think, if autifony wanted to be really sure, they would have a longer period trial, i mean the general feel has been that these potassium channel openers should be given time to work. so, considering the millions autifony/glaxo have at stake here, i would surmise...

oops...well, at least they volunteered for the pre-clinical trial

it's reassuring to know that healthy rats of all ages volunteered.

this is interesting and good news regarding autifony trial firstly its a SHORT 4 week trial, not something dragging for months secondly they expect 000063 to work quite fast, not months like some thought thirdly it gives us a better idea on how to dose retigabine once we know the trial dosage...

Great find, thanks. I've pasted the text here. it is just so relevant to all of us: "Previously found to be involved in special forms of epilepsy, heteromeric KCNQ2/3 potassium channels have now revealed their potential to be attractive targets for the treatment of chronic neuropathic pain...

i also hope to be starting retigabine soon. wouldn't it be wonderful if somebody with chronic tinnitus was cured by retigabine. it could happen, maybe it already is happening.

it is a long thread with vital info scattered, so why not pin a notice at the beginning with dosage info and studies to show doctors plus link to progress reports

@Christian locoyeti's given you some great advice, don't give up on the retigabine too early, especially if it was starting to work, many drugs take time to work, there's still hope

Okay we've got a whopping 52 page Retigabine thread. Well done everybody Can anyone COMMENT on the general result of the online trial? From a glance, it seems good no matter what caused the tinnitus. Anybody doing it in the UK ?

We feel for you too steve, thank you for the kind words, all i can say cos its all i know is that were uk residents and she went thru assessments and various paperwork, she was so bad she wasn't even requested to be seen at an official building its uk govt stuff, youre entitled to the same fair...

she groans in pain from morning to night, can hardly walk, talk, sleep, eat, housebound 19 months, 3 s attempts, last time i checked, she was crying. beautiful children need their beautiful mother back, legally tested means it's legit. trust me friend, there's tinnitus and then there's tinnitus...

http://www.upmc.com/media/NewsReleases/2013/Pages/pitt-team-finds-mechanism-causes-tinnitus.aspx “We found that mice with tinnitus have hyperactive DCN cells because of a reduction in KCNQ potassium channel activity,” Dr. Tzounopoulos said. “These KCNQ channels act as effective “brakes” that...

@rtwombly, good idea about the professor. i'm sure he'll appreciate your acknowledgement of his achievements. with regard to early access scheme, the regulators probably need some clinical trial feedback so yes it would be wise to wait for phase 2 results, but at least brief him on the idea for...

@Rube, yes we will be asking doc for retigabine. @Hudson, my partner is long-term chronic, even then unable to travel or do anything really thanks for the comments, they are a comfort.

we can't generalize about cannabis. high cbd, low thc (psychoactive), is a different medicinal creature. its like comparing apples and oranges, they're both fruit but different.

My partner has been suicidal. I will do whatever I can to help my partner and the good people like yourself to ease our group suffering. I applaud your concern to handle this correctly and appreciate all comments you have made. If we can early access AUT00063 it would be a wonderful thing. I...

1. It doesn't matter if there has not yet been extensive human testing. No data is required. Under the govt scheme, we simply seek to take the same 'risk' as other phase2 participants. 2. Altruism means selfless concern for the well-being of others. I sincerely hope that Dr.large will help...

Thanks for the cautionary advice Steve. Let's keep this clear and simple. No-one is making demands. And nothing needs proving. My partner is a UK resident, legally tested & recognized as debilitated by tinnitus. A govt scheme now allows companies to make available medicine which is not yet...

Okay MPT, I think this would really be worth pursuing. I am certainly grateful you authored this thread because alot of good has come out of it to help others. I too will be asking for retigabine in the meantime. With regard to Charles large, what's the best way of contacting him? I'll keep you...

this also caught my eye http://time.com/105385/new-access-to-experimental-drugs-for-terminally-ill-patients/ Nationwide, people with a terminal illness for which available treatments aren’t working can seek a Compassionate Use Exemption to be included in a clinical trial of a drug or procedure...

I came across this posting by Benryu in the Flupirtine thread. It is so informative, I'd like to copy-paste it here: (thanks Benryu) bottom-line = retigabine might do the trick Potassium channel modulators should not be compared, there is a ton of parameters and subtilities that can change...

maybe the anxiolytic effects of retigabine give it a double advantage. looking at the results so far, and these good people are telling us how it is (probably more trustworthy than a clinical trial!), retigabine is WORKING. i mean, if the autifony trial reports back this kind of result...

let's not be over-suspicious of the Chinese, they make almost everything we have. If its a real lab they can do the job no problem,and they will be looking to please because they want repeat business. a shame you cant get it from your doc, as its also been indicated for anxiety! i might be wrong...

how many chronic in our trial?

thanks johno, i really do wish you the best of luck i hope it helps you, keep us informed

well at least we can help the rats , they have feelings too

unlikely as it seems AUT00063 could actually be a cure, it does a very specific clever job i'm really interested to know whats the earliest it could be fast-tracked ( in a perfect world) ...yes i know its not a perfect world, THOUSANDS OF MILLIONS of dollars have been spent compensating our war...

how many chronic cases here have been helped by Retigabine?

what's the MOST OPTIMISTIC timescale on AUT00063 becoming available? Wild guesses gladly accepted. Remaining in optimistic fantasy mode, if Autifony is the real deal, would a $50,000 bribe get you a bottle of pills or is it only cops on the take.

what's the MOST optimistic timescale on anybody getting AUT00063? If phase 2 has problems(strictly hypothetical worst-case-scenario of course) , can we still get it by any means? has anybody got hold of retigabine in the UK yet? I have friends who would sell their houses and bodyparts to get...

I would like to wish good luck and health to all participants in this wonderful trial. as I'm new here, could someone please tell me how many people are trialling Trobalt, how chronic and what's the general picture emerging (looks favorable from what I can see). it would be nice to see 50...