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http://onlinelibrary.wiley.com/doi/10.1002/anie.201000620/abstract The Engineering of an Orally Active Conotoxin for the Treatment of Neuropathic Pain Maybe the next thing to try

ZnPy is a very commonly used chemical unfortunately it doesn't cross BBB so the only way to get it to the brain is injection into the spine, not practical in any way. Another method is develop another molecule which has a similar MoA on the receptor but cross BBB, which can be a monumental...

Dear @attheedgeofscience, Thank you very much for sharing with us your theory regarding hearing loss and T and your experience with LLLT/stem cell/HIFU. I developed T during mid-Oct and when I went to ENT/Audiologist at late Oct my hearing test turned out normal. T didn't go away and I went to...

Bad news. Can't get my neurologist prescribe RTG he read all the pre-clinical studies I presented to him but he told me he's reluctant to prescribe it because there's no clinical data to support the use of RTG. He didn't even prescribe me Tegratol. He told me "I'm sorry there's nothing I can do...

I only wish that AUT is successful and won't lose its efficiency after a short while like RTG apparently does

always bear in mind that this is NOT a double blinded placebo controlled trial with rigorous protocol to follow, like the AUT-00063 trial does (which IS a double blinded trial). Even with double blinded placebo controlled trial there is a problem of replicability. Interpretation of clinical...

That's a bad news, really bad news I would like to see some trialees who have reported drastic change in T level (some even reported hearing silence or near silence) doing the same test plus there are more negative outcome progress reports recently, my heart sinks to the bottom of the sea

Not sure if anyone has posted this study before http://www.hindawi.com/journals/np/2014/145943/ Application of high resolution dti MRI on studying brain disorder http://www.ncbi.nlm.nih.gov/pubmed/22677150

muscarinic receptor signaling reduction of PIP2 I have a gut feeling that this may have something to do with the loss of effectiveness of RTG after long term use, anyone interested in researching into this issue? http://www.ncbi.nlm.nih.gov/pubmed/23650395 Pharmacological augmentation of...

@amandine I think the only way we can know the objective loudness of a subjective T is by minimum dB of masking white noise not the TQ stuff which is subjected to psychological effects. By using masking sound you either hear T or not. This is potentially valuable in validating whether the...

He had made it very clear, there is NO double blind placebo controlled study that confirm RTG is effective. and he believed that RTG does not work because in the past all candidate drugs failed double blind placebo controlled trials so he does not believe there exists a pharmacological approach...

Tinnitus? The medical community doesn't even give a shit They tell you to go for an MRI and if there's no tumor they tell you there's no cure learn to live with it it's not going to kill and then kick you out of the clinic or better tell you to listen to Goddamn white noise for the rest of your...

For those lab rats on TT we seem to have a continuous supply of novel molecules to play with Brivaracetam (UCB 34714), similar to Keppra but 10 times more potent, currently under Phase III trial http://www.ncbi.nlm.nih.gov/pubmed/17199019...

Regarding the Flupirtine question I did found an article dating from 2006 stating that it is not effective at a dosage of 2*100mg daily against T http://www.ncbi.nlm.nih.gov/pubmed/17114151 May I know where have you seen reports saying that it is useful against T? I don't know but people are...

Many A/D and tranquilizers can cause T, yet ironically they are frequently prescribed to T sufferers to help them cope with the situation. It is well understood that withdrawing from benzo can cause T and H (look at benzobuddies to see all those poor souls who got T and H due to benzo withdrawal).

And effect on T when compared with RTG?

To me there's no difference whatsoever between psychological and neurological a psychological T also reflects underlying neuronal hyperactivity is probably not much different from a neurological (ie. with hearing loss) cause

I'm afraid someone is taking the risk of going beyond the maximum recommended dosage to see what will happen

Yes, some people even do a electrocochleogram and brainstem auditory evoked potentials I did a 8-16kHz but not electrocochleogram and brainstem auditory evoked potentials

first go to ENT to check if there is hearing loss if no you may consider trying Potiga?

Congrat to you. If I can have 3 days of silence I can go to grave immediately afterward without any regret

chronicity as a predictor of treatment outcome: single variable linear regression, n=17, slope=-0.333 (95%CI [-2.4, 1.8]), SD=1, P-value=0.744, R2 = 0.007 based on available data, chronicity of onset is slightly negatively correlated with outcome but it is not statistically significant...

Just a random thought, gene therapy might become another line of research direction for T therapy If you get an RNA aptamer which acts similarly on those potassium channels, put it behind a strong DCN fusiform cell specific promoter, pack it into a lentiviral vector, inject it into the brain...

Would be a good idea if someone can get a fMRI/SPECT/MEG/qEEG scan before and after taking Retigabine, and before/after dosage escalation/reported significant T reduction It may shed some light on how it works on auditory pathway and why for some people it loses efficiency after a while.

It seems that RTG really has an effect at least when it's in your system and it's probably not placebo Hopefully a derivative molecule with less toxicity/side effects better tolerated can be used for even longer experiments (ie. several years) to see whether they can slowly induce plastic change...

I wish I only had H, at least I can live out my life peacefully in a quiet remote place far from any noise.

RaZaH had good response at low dose too

http://www.cell.com/current-biology/abstract/S0960-9822(14)01037-9 Our network-centrality analysis reveals a widespread decrease in connectivity in most cortical and subcortical areas. In the cerebellum and thalamus, however, we find localized increases. It seems that SSRI has more horrific...

My H preceded the onset of T

Since your case is still acute would you consider trying Retigabine?

@attheedgeofscience Please pm me I'm in contact with a Professor in charge of ENT clinical trials in a local university (he is also my T doctor), I am going to ask him for his opinion on the possibility of trialing Retigabine on T patients, whether off-label or a open label pilot study. I need...

I just informed my Otoneurologist (top T expert in my country and director of rTMS clinical trial in a local University) about the AUT 00063 trial, surprised that he had never heard of the Autifony trial but he seems to be interested and he will be gathering some info from his friends (even...

Actually it seems that Maxipost (BMS-204352) had indeed been tested on human subjects, who are stroke patients In healthy humans, single and multiple i.v. doses of BMS-204352 (0.001 to 0.2 mg/kg) were safe, well-tolerated and without psychomotor function effects. Multiple doses of BMS-204352...

I just discovered that my country's drug office lists Xanax as a more dangerous and more restricted material than Trobalt. Trobalt is classified as Part I, First & Third Schedule Poison, while Xanax is classified as Part I, First & Third Schedule Poison & Part I Dangerous Drug. Part I Dangerous...

http://www.benzobuddies.org/forum/index.php?topic=96554.950 @Christian78 sorry to hear that, that's also why I hesitate when it comes to discussing with my Doctor about the possibility of off-label Trobalt. I'm wondering are you the only one using Trobalt long time (2 months+) who gets bad...

Another piece of interesting information, a bit old though, don't know if anyone has posted it before Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats Conclusions: Our findings indicate...

Same situation here. Would definitely like to be a lab rat of AUT 00063 but I don't have hearing loss.

So it only began on Nov. 28 when the first test subject supposedly took his/her first AUT 00063 pill, not October, result too early to tell

Yeah there's still a huge missing link. I also based the speculation of CN involvement on the fact that body posture/gravity significantly affect my T and CN processes both auditory and somatosensory system input and relay it to the cortex. When my T spikes it is accompanied by not only...

Of course I can't be sure unless I experiment with it myself, but I suppose it's a very dangerous drug which Drs don't normally prescribe to T sufferers. @Mpt got it from a relative who's also a Dr. Just want to be more cautious, I got this crap with prescribed CNS medication.

https://www.tinnitustalk.com/threads/retigabine-trobalt-potiga-%E2%80%94-user-experiences.6047/page-2 johno claims his central T induced by Xanax was cured

Benzo induced T+H probably because Benzo (more specifically Benzo tolerance/withdrawal) caused a down regulation of GABAA receptors and the subsequent GABA/Glutamate inhibitory/excitation imbalance, along the central auditory pathway. This is also the same proposed mechanism for noise induced T...

Attention! Someone on a Benzo withdrawal support site experimenting with Potiga also independently reported significant improvement of her benzo-induced T with it. She only takes Potiga 2 times a week "Actually, very well. I only take 600mg twice a week. My T is better than ever. The side...

I suspect I have a hearing loss at 1853/1854 Hz (using headphone) or maybe 1891Hz (using computer loudspeaker), missed by standard audiogram which only tests 125/250/500/1000/2000/4000/8000Hz I also discovered certain frequency of sound can trigger distinct pattern of T and change the tone of T...

If the Kv3 potassium channel theory is correct, so it is supposed to work for T without hearing loss too? Then why does the company emphasize Aut00063 is for T with hearing loss?

According to clinicaltrials.gov most rTMS trials require 6+ months after onset, some 1year+, that's why my Dr. refused to let me try the rTMS trial he's currently testing (the rTMS pilot trial my Dr. currently conducting is not on the website)

Interesting, it seems that a number of volunteers who are trying Retigabine on this site also report an effect on T spikes.

how much benzo/for how long have you it before you got T? I only took a small amount always 0.004-0.5 for just 2 weeks before I got this thing Is it possible that benzo-induced T can go away?

it implies that different people have different neuro chemical pathway of T generation/maintenance, therefore future treatment development must be based on personalized diagnosis, like the field of oncology is currently moving towards. A tumor in the liver could share more genetic commonality...

I am considering ascending to the top of a mountain during a fierce thunderstorm and getting my brain hacked by a lightning bolt to see whether it can help my T

f..k all psychiatrists and psychiatric drugs, they shattered my life

It started in mid October, when I was withdrawing from a low dose of Xanax after a short term use. The Dr gave me this to treat tricyclic compound poisoning. I only took that sh.t for 16 days at low dose at the initial titration period before I developed serious neuromuscular side effects which...

I, as well as many other people, first suffer from T+H during withdrawal from those filthy f..king psychic drugs (Xanax, AD, tranquilizers). Maybe they should take a look, maybe the drug-induced T+H could shed some light on the mechanism of generation/maintenance of T and H

beware of benzo, I got 24/7 T and H during withdrawal from very low dose after only a very short term use.

cause of tinnitus most probably Xanax withdrawal, I only used it for 2 weeks at a very low dose but unfortunately got tinnitus during dosage reduction Dr. told me I could ct off 0.25mg after short term use, huge mistake. 24 7 extremely unpredictable sound, completely devastating. Odd enough T...