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It hardly bothers me nowadays (compared to before) unless I'm in complete silence, where it feels like hell. Like, it's still very noticeable, but I try to keep my mind off it and focus on other things. Could be because I'm currently super busy nowadays, could be because of AM-101 (unlikely)...

Late update: The improvement that I noticed previously no longer exists (and only lasted for approx 2 weeks). It's back to the same level as before treatment started. Altho, I am 90% less annoyed by it, so that's good I guess.

Firstly, the spike I mentioned in my previous post has stopped. Also: I don't know if this is just a psychological effect, but I feel like the tinnitus has actually dropped in volume a bit, from like a 6 to a 4. This is based on checking the volume when in bed at night, when in a part of my...

Got my third set of injections today. Tinnitus slightly is louder, just like before. Just like Oddv said about the open label drug, it leaked out of my ear - which the 'closed' study drug didn't, making me think I must have received the placebo previously.

Had first open label injections on Tues, and another pair today. Results so far are the same as when I did the blind study; slight increase in T vol, and clogged ears. Got third set of injections tomorrow morning, hopefully I'll see some changes but I've mentally prepared for the worst.

Had round 1 in June, and it's likely that I'm getting the real thing on Tuesday. Tinnitus level feels unchanged, annoyance is way down tho - probs just habituation or whatever it's called. Hopefully, the second round reduces the volume as well!

Potentially a treatment.

I don't think the drop is a cause for concern. Oh. For me, he just used cotton wool (coated in the local anesthetic) and something (not a needle) to insert it into my ear). Also, forgot to mention in my previous post: The Doctor also told me that my eardrums have healed up and that I don't...

FUV1 (D10) - 18/06/2015 For some reason I thought I'd have another injection today, but it was just a follow up to see how I'm doing. The actual treatment was just the three (sets of) injections I had last week. Next time I'm treated should be the real drug for sure, but that's still quite a...

Ears are both >95% back to normal. I think T may be back to pre levels but I'm not 100% sure if that's the case or if I've just gotten more accustomed to it.

Nothing has changed since my last update, starting to think I got the placebo but it might kick in later for all I know. Glad everything went well!

It’s not an ID card per say, but I just didn’t really know how to describe it. Strange that you don’t have one though. Ask the nurse looking after you for it, maybe she forgot? I didn’t get it till TV1 so that may also be the reason you don’t have one yet? Here’s the front side. The reverse...

TV2 – 9/06/2015 Fewer tests than TV1; only temperature, blood pressure and heart rate if I remember correctly. Injections to both ears felt relatively painless, I was surprised when he said “that’s it” since I was still waiting for the ‘spike’. Eardrums still feel numb, tinnitus feels louder...

Not sure if this is what you're looking for, but here's a list of prohibited medicines (written on the back of an AM-101 'id?' card that i'm to always keep with me) Hope this helps.

TV1- 08/06/2015 Went in early in the morning. They took a urine drug test sample, did a hearing test, and a tinnitus match test. The doctor at my site was very nice and answered all my questions + discussed peripheral and central tinnitus with me. I had the injection in both ears following the...

I will try and message him to see what this is about.

Booked in for Monday for the first injection, then a few more during the rest of the week. Will report back.

It's an old pic, I'll probs change it soon. It's from when I interned at a neurosceicne lab in University College London (UCL) (also known as the place where autifony trials are happening). I'm not a researcher but I'm considering becoming one/working for a large pharma. The last time I worked...

I have a login that lets me access the full paper, but it's too large to attach here. I can copy & paste parts if anyone wants something specific.

In my opinion, gene therapy and stem cells could both prove to be useful for treating or even curing tinnitus in the future - Theoretically they have the potential, but we've just gotta wait for results. I have some ideas of experiments i'd do if I had a lab + funding and i'm assuming that some...

Recently been for screening, which involved a hearing test and blood test. I was also shown how to use the e-diary (below is a pic of the back of the e-diary). Should be getting the first treatment in around 2 weeks.

Cheers! That post (thread starter) was from Feb and I have a completely different mindset now. Back then I was an absolute mess.

Hmm I'm not too sure tbh. My uni are really nice about the whole thing and offered me assignment extensions which I declined since (didn't want to spend much time on assignments when my exams are worth more). I think your best bet would be to see your uni support system if you have one, or head...

I'm booked in for a screening session on the 26th, then the first injection i think 2 weeks after and I'll report back with all the details etc. Would have been much earlier (i.e around now / last few weeks) but I'm currently doing academic exams so need to wait till they're over.

Sorry if what I wrote was misleading, but this individual has been working on NMDA receptors, their agonists and antagonists etc for reasons other than tinnitus. My comment was just an informed opinion of his that doesn't really 'mean' anything scientifically.

Like 2 months ago

My exact thoughts.

Good find. Here's a link to the paper, since the link on the BBC article isn't currently working http://www.cell.com/current-biology/abstract/S0960-9822(15)00278-X

No, I wasn't listening for it. This was back from when I didn't have tinnitus permanently. I don't think there is always a causal relationship between hearing loss and noise induced tinnitus; there are people with noise induced hearing loss without tinnitus and vice versa. But that's just my...

And how can you be certain that this is the case? I've previously gotten temporary tinnitus that's lasted a day, once or twice after clubbing with earplugs in (~1 year ago) Remember, loud noises aren't only conducted through the ear canal; it can also be conducted through the skull (tap you...

Turned 21 two weeks ago, clubbing and loud music venues are over for me. I always wore ear plugs when going clubbing (which was not even a frequent occurrence) in order to protect myself from tinnitus since I've known about it for years. I ended up with tinnitus anyway. Definitely not risking...

World of Warcraft, Mass effect 2, Starcraft 2

I haven't noticed any change in sensitivity, just spikes of pain.

Maybe I'm just being paranoid, but I've been getting spikes of pain (lasts ~1-2s) in what feels like my inner ear for the past few weeks (once every few days), but they've recently increased in frequency (got a few today and yesterday). I will bring this up in my next visit to my GP, but I'm...

Yes

Is this the paper? http://elifesciences.org/content/early/2014/10/17/eLife.03564

This is from a different paper, and I have no idea what it has to do with my comment.

Nobody for sure knows the true cause for tinnitus unfortunately, but I suspect it may be both the ears and brain, i.e damage in not necessarily ear structures, but ear neurons (remember, neurons connect to the CNS), which leads to hyperactivity in the brain. If this was the case, a cure would...

These types of studies should be taken with caution when deciding the dosage of a drug to take. This paper is an in-vitro (outside the body) study thus does not account for the pharmacokinetics and side effects of a high dose, regardless of the predicted high therapeutic effects it has found. I...

I've always worn earplugs in loud situations (clubs, loud bars, etc) long before I got tinnitus in order to prevent hearing loss/tinnitus. Since I ended up getting tinnitus anyway, my use of earplugs has been increased to include traffic, trains, and most things above standard volume.

Stem cells might, in the future (no promises), be able to be induced into differentiating into functioning cochlear hair cells.

I'm not sure about Autifony, but there is some discussion of AM-101 side effects in the publicly released clinical trial paper, and those that are eligible for the AM-101 trial are given detailed information regarding any possible side effects a while before the trial begins.

The positive results from Trobalt in this thread are making me want to devote my life to tinnitus research. If I do decide to continue as a research scientist (I'm considering applying to work for GSK, Novartis, Pfizer, etc), this will definitely be my area of expertise.

We are what we repeatedly do. Excellence, then, is not an act, but a habit - Aristotle

I was mistaken, I can do a stats test for it. I previously assumed i'd need to do a t-test, then realised that only a z-test (or chi squared) would be possible for that type of data. Both statistical tests were two-tailed tests, and α=0.01 Tinnitus louder / worse Using the data that 6.966 out...

Why is that the case? It seems to make sense to me, and that's how I interpreted it. It makes sense, but his "you might end up with nothing" comment indicates unnecessary worry, hence my comment that invasiveness does not detract from it being a uncomplicated procedure. Agreed. I'm under the...

It's an injection, and therefore is invasive by definition. This does not detract from it being a common and uncomplicated procedure, however.

Here we go again... May still give it a try tho, never know what it could lead to

Seems like I've been accepted on to the trial after calling them. Will keep this thread updated with progress.

Not too sure what they mean by 'Tonic' but I think they're just talking about normal Zinc. Could be wrong but as far as I'm aware, the paper doesn't conclude that Zinc is able to reduce tinnitus, but that it is involved in some of the mechanisms behind it.

I am able to get access to the paper, I can message you the PDF if you wish. EDIT: Nvm just attached it instead. No idea why there's a water mark on it tho...

I have tried both capsules and tea. Doesn't seem to have a noticeable effect on me unfortunately.

Has anyone managed to get this without a prescription?. I just want to be able to finish my degree without constantly losing motivation due to T. Final exams in 6 weeks :/

How did you guys sign up for the trial? I registered on the website weeks ago but haven't heard back since. Should I just give them a call?

I'd say mild tinnitus is that which does notdirectly affect sleep.

Do you have a link to the study? I'm curious to read it. EDIT: Nvm, found the abstract http://www.autifonytherapeutics.com/publications/Turneretal2013-TRI_final.pdf

It's possible that it's your head rather than both ears, mine and some other members have that as well. If it's on the NHS, an audiologist will give you a hearing test, then you will go in to see an ENT. He/She will ask you about its origin and do some tests to see if your cochlea (inner ear)...

It's a hormone that helps you sleep better. If you're in the UK, you won't be able to get it without a prescription unless you buy it internationally.

It happened now and then before tinnitus onset, but a few days before onset, it happened noticeably more than usual (once every few mins for like ~20-30mins), and I even said to myself that it's like a tinnitus marathon or something. Few days later.. boom, permanent tinnitus (not the save volume...

I'm also in my third year of university and I feel for you man, it really isn't the best timing. There really should be more awareness for this type of thing around campuses etc, even putting a sound warning at nightclubs would be a good idea.