Search results for query: *

I'm actually glad you are still around and it is good to hear from you. I just couldn't get excited over 5 dB when I am down 80 dB to 120 dB in most frequencies. Totally agreed with what you said though. Many people still clung to hope after the trials kept coming back disappointing. I was...

Wow. I can't believe this is how it ends. I opened this thread 7 years ago with lots of hope but was always cautious after the previous failures. I lost faith after the audiograms didn't pan out, but always held out hope.

This makes sense then. They are going to keep going with the existing formulation and see if they can get it approved as a speech understanding drug. This would allow them to start making money to keep the company going and continue research. The new drug candidate could be what they have...

The marketing was different back then than it is now. Stanford Cure for Hearing Loss... A cure for hearing loss in 5 years. Then it became a cure for hearing loss in 10 years. Then everyone came out and said, hey this is a lot harder than we thought. Then the trials GenVec started and everyone...

When I first got tinnitus, I got hyperacusis to go along with it. The stress of having tinnitus was too much for me. Lots of anxiety... That will cause hyperacusis as well. As I got used the the tinnitus, the hyperacusis slowly went away. My daughter has lots of anxiety and has hyperacusis to...

Everyone's hearing is different and will degrade at different rates. Bad genes and a few rock concerts and here I am... Some people with good genes can hit thousands of rock concerts and have no issues. Eventually we all get older and will feel it eventually. Most people don't care until they...

I was hoping the music industry would get involved at a certain point. They seem to go hand and hand...

It is relevant to the company and their future. That is the only reason why I brought it back up. We all want the trials to keep going and this could derail that. Hopefully it turns out to be nothing. The results from the next trial is still a ways out. This thread would go dead if we didn't...

You just said it. Team of lawyers that costs money even to hold them and for them to get familiar with what is going on. Agreed, until something is filed, there is no reason to do much, but given the number of firms I saw on the list I think it is coming. My only concern is that this starts to...

Right now it looks like it only reaches up to 8 kHz... They will need to figure out something for a delivery method to get further into the cochlea in order to reach those frequencies.

Agreed that it won't be much, but they will still have to do it at a certain point. It just eats into the money the company has for trials, employees, etc. Frivolous lawsuits happen all the time. They won't be able to recover those costs though unless they can prove the lawyers had no case...

Right now they are all working for free. The number of law firms on this is pretty long. If they think there is a sizeable settlement to be had they will pursue it. Fishing is only the first step. If they do this to 10 companies and 2 pan out then they have won. It is common practice for them to...

They aren't just fishing, they are collecting fish. Right now they are waiting for more people to contact them and just taking names of people and institutions that have lost money. They will tell the people that they do'nt have to pay anything and have nothing to lose and that they will recover...

You are right that they are just investigating, and the case could not even have any merit, but I've been through this before. These law firms have the paperwork all written up from the last case they put together. They find the most similar one, change some words, in some cases they even...

There are going to be huge losses from investors due to the run up and then the subsequent drop. Most of those law firms will work for free in hopes of a big payday. Investors will call them because it costs them nothing and they lost lots. Frequency Therapeutics will have to defend themselves...

After looking up Frequency Therapeutics' stock symbol FREQ, the only thing I see are class action lawsuits. Even if they have something that might work for some people, they could spend years and lots and lots of money defending themselves in court. It just isn't looking good for them, no matter...

Yes... The theory is if the hearing increased 10 dB at 8 kHz, maybe it did more at the higher frequencies since they are easier to access. Unfortunately in that study they did not test above 8 kHz. Most people lose these high frequencies first, 8 kHz and above, and that is usually where most...

Agreed... Those are pretty strict. Even with my extreme hearing loss I don't go every year to get tested. My hearing loss is happening much faster than most, to be almost deaf at 48, but even then it has been a pretty stable loss over the years. They are trying to keep the company going and see...

We are all looking for something different and that is why the sentiment is so far off between some people on this thread. Those of us that are disappointed were looking for audiogram improvements. To be fair this is a tinnitus forum and not a hearing improvement forum. It was hoped regaining...

From reading the article it seems like they are still missing pieces to the puzzle. I remember when Novartis and GenVec tried just Atoh1. It didn't work as anticipated. Hopefully if they can find the right combination, this could be a good therapy.

A Combination of Genes to Enhance Hair Cell Regeneration in the Adult Mammalian Cochlea Good article. I know previously they just concentrated on ATOH1, but it looks like a combination of genes yields better results.

Frequency Therapeutics' issues aren't just limited to dosing methods. They have many issues that they need to address before this can go to market. They have already done several single dose studies and the results are still not what they expected. I know we have all speculated on this thread...

The fact that they are hiring doesn't mean anything. They are a publicly traded company. They will keep going until FX-322 is proven successful, or they run out of money.

Frequency Therapeutics are just trying to make the best of what they have got. As we have mentioned, at this point their plan is to just go to market with what they have so that the company doesn't go bankrupt. Maybe in time they can figure out why FX-322 didn't work as intended and improve on...

I guess this is what we end up with... An injection that helps with word scores. To be fair, if they go with this, it is a huge market. Everyone of us will sign up for an injection no matter how small the benefits. If it makes tinnitus 5 percent more tolerable, then that is a benefit as well...

FREQ stock price reflects what you are thinking. I have never seen a drug get approved that would have so many restrictions on who can take it. There are usually side effects that must be disclosed, but to say you must be between certain ages and have a certain hearing threshold is going to be a...

FX-322 was my last hope to get my hearing back. When I first started this thread, I was moderate/severe. I am now moderate/profound. It looks like a cochlear implant is in my future. Can you provide any links to the cochlear implant that is 99 percent like normal hearing? Good information. It...

I'm just not seeing how the severe hearing loss trial is going to show any major improvements. This was disappointing. We can now limit the type of person it helps and the amount it helps if the severe hearing loss trial is successful. I'm having an issue with this quote: “To date...

Agreed. When this whole thing started, I was hoping to throw away my hearing aids as well. At this point it looks like we might get some hearing back in the 8 kHz range, get better word scores and keep our hearing aids. I am ok with that.

If FX-322 can restore hearing 8 kHz and up, there is a good chance this could help people with high frequency tinnitus. We are just waiting for more results to come out.

And... From what we think... There should have been improvements in the 8 kHz to 16 kHz range as well, since FX-322 would have hit those areas first, which would have only helped with the word scores. Word scores also dropped in the 1 to 2 year time period... I wonder if any improvements in the...

At this point we will have to wait and see what the additional trials tell us. My only point was that FX-322 was created to cure hearing loss... not increase word recognition scores. Debating on which one is more important is not going to help any of us. If the additional increased word scores...

This is a good post and you are right! They are pioneering this stuff. I just find it really hard to believe that we have come this far and we are still learning things. They are a publicly traded company now, not a research firm. The expectations are a lot higher now. Not trying to be...

I would have preferred the opposite to be honest, but it isn't about what I want. We are trying to cure deafness. We are trying to cure tinnitus. That is the whole point. Deaf people can't hear and it shows up on their audiogram. They just want to hear birds again. There are 466 million people...

By the time someone actually goes to the doctor, they are usually down 20 to 30 dB at the higher frequencies. It shows up in the audiogram and the word score tests. You need the word scores and the volume brought back up at those frequencies to really help someone. As of right now it is still...

How many people go to the doctor and say they have perfect hearing and they just have trouble understanding a few words... It is a very small subset of people.

My first sentence was poorly worded. Agreed. Everyone, including Frequency Therapeutics, were hoping for better results from the initial Phase. A 20 to 30 dB improvement, across all frequencies, would have been a nice start. Completely restoring hearing and getting rid of tinnitus would have...

They should have foreseen this if they thought it was going to be an issue. They only came up with the idea of multiple injections based on the poor results of Phase 1. They developed an entire clinical trial around more is probably better... We can try to explain away the results of the trial...

Where did you get this info? Can you share the link? Is this the same Chief Scientific Officer that has been offloading shares all this time? There will probably be another run up in the stock price before results from the next trials. It is probably a good sign though. This is the FREQ...

It might help with extremely high frequency tinnitus, high frequency hearing loss, and it might help with word scores. That is all we know for now. It is not going to be the cure for hearing loss as some people originally thought. Everyone had different expectations on what they wanted the drug...

I should have clarified what I meant by "it doesn't work" and probably should not have used that wording. In a post after that I outlined what we can hope to expect from a single dosing regimen. As I have mentioned previously people were "hoping" and "expecting" better results than we got in...

It will be interesting to see what they come up with in the next trial results. I think at that point they will know what they have. I still think there is much more potential to FX-322 and they really need to figure out why they are not getting the results that they were expecting.

I thought that the severe group would have fewer supporting cells so it would be less effective... I guess we will see. So right now, with what we know, what is the best case scenario in a single injection scenario? If you have almost perfect hearing with a slight loss of 0 dB to 10 dB at 8...

Totally agreed!

I'm pretty sure improvement in the audiogram was what they were initially after. What we are getting is something completely different. I bet they were surprised at the outcome of the Phase 1 trial, and even more surprised at the outcome of this last trial. They and everyone else was hoping for...

If it worked, the guy that got 4 FX-322 injections should have gotten some benefit from the drug and it would have showed up in his audiograms and word scores. Or the guy that got 3 FX-322 injections and then the placebo injection last. Or the guy that got a placebo injection and then 3 FX-322...

I'm not sure I believe that it was completely a trial problem. The non placebo group should have had some hearing restored if it worked like they intended and on average more/improved word scores than the non placebo group. They really need to figure out why it isn't working as they had hoped...

Vaccine development is a long complex process. It usually takes 10 to 15 years. We did it in one. If there was an urgency and the world banded together, we could have something in a year, just like the COVID-19 vaccine we have now. I disagree with some of the comments... Money makes the world...

Frequency Therapeutics (FREQ) There is already a thread, link above, about FREQ stock in the "Stock Chat for Benefactors" category. Due to popular demand, let's try to take the stock talk over to that thread and keep it out of this one.

I read an article that said they will have revenue of $43 million in 2021? I'm confused. What do they sell that they make revenue from? I thought they were strictly in the research stage for all of their offerings. Agreed with everyone though... The stock is coming back, but it could be people...

When I got tinnitus, I went to the doctor and they prescribed anti-depressants for my severe depression. They said "take these and your depression will go away." I took them. A week later I was my old self again after months after months of feeling horrible. When I checked in a week later with...

Nice picture... This thread was created for anyone to talk about anything they want, related to Frequency Therapeutics, and cats are just as good. You can talk stock price, voice your opinions... Good or bad... Tell us your story and let the "experts" help or anything else you want. It is a...

Are you down 10 dB at 8 kHz? If you are down 10 dB at 8 kHz and you only need 10 dB to get back to baseline, you might actually be one of the few people that FX-322 could help with, based on what we know up to this point. My theory has always been if you can get back to baseline on all...

This is when they test understanding words mixed in with a background noise. This would be similar to talking in a loud bar. When you start to lose high frequency hearing, usually this can be found in the words in noise test. Some people hear "ok" in quiet environments and not good in noisy...

The stock could go up between now and then, but agreed with your assessment. At this point its just best to sit back and see what it goes.

You are right. I just looked and up till three weeks prior there was a lot of selling taking place that dropped the stock price. March 23 is the day it dropped a lot, but February 19 is when it started dropping. Some of that was probably people profit taking. It went from $55 to $36 though...

You nailed it!!! The whole post!!!

I don't think insider trading will be an issue. The guys at the top have been selling the stock consistently over the past years. If you look at the trades... they generally make over $500k per month in additional income. I doubt they would do a "bigger" stock sale than normal before the results...

@FGG is right. We need to stop the going back and forth. We did this when the Phase 1 results originally came out. Rehashing this won't get us anywhere. We really need to accept the data in all of the trials and move on. If people want to keep questioning the data just go back and reread all of...

Agreed... At this point there is no reason to doubt the Phase 1 data on the word scores and possibly the small gains on the audiogram. Phase 2 has proved that any manipulation or errors will come through in the study. The real question now is where do they go from here.