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As a long time tinnitus sufferer since an acoustic trauma in 2015, I can only hope to help by telling you that it does get better with time. I was where you are now at six months in. My marriage broke down, I faced full depression, and had suicidal thoughts. Believe me, it gets better; how long...

To be quite frank, I have never heard of those side effects with regards to Clonazepam. Actually it is supposed to be first line treatment for anxiety and panic attacks. You might be in more distress with your tinnitus since it is of very recent onset. The first two moths I was a...

Propranolol won't help at all. Clonazepam (Rivotril, Klonopin) definitely helps to take the edge off tinnitus. In my case I usually take 1 mg with an empty stomach (effect seems quicker and last longer). The secret is to use it very occasionally only in times of real real distress, otherwise...

I don't think anyone active on Tinnitus Talk forum has been in the trial. Even with a non-disclosure agreement, basically nobody here is using their real name. During the AM-101 trials we had a lot of posts from people participating in the trial (it was a large trial). So I really don't...

Interesting conundrum. They are doing both studies at the same time (FX-322 and OTO-413). I don't really know which one would potentially benefit more since I mostly recovered from my mild hearing loss during these four years but still have tinnitus (high frequency) in right ear (I know I have...

No one can truly say. It all depends on how well it goes in next the trial. This time they will also be checking how it works for tinnitus. If the results are mind bending and very successful i am positive that we will be seeing something in less than 3 years with fast tracking. If the...

I not available anymore. Trobalt has very hard side effects that why it was discontinued. I tried it myself and it gave me some of the more quiet days i had ever had and at some points i thought it might cure me. Soon i realized that the effect is only transitory and you have to keep raising...

AM 101 was intended for the acute phase of tinnitus (first 3 months), later they extended the trial for up to a year and both fail to give any positive result. Similar way of acting in the same receptor (NMDA) but with a stronger (more affinity or more potent) product than AM 101 as i...

Jason37 is not in the trial.

It is a small trial and probably the people that are in it are not active in the forum or the tinnitus community. So hopefully they did get better and had improvements and told their families, doctors and friends. Also not everyone is posting everyday on Facebook or Twitter so I am keeping...

I think that they must be very rare. I had a lot of injections while in AM-101 trial with no real discomfort and each puncture was pretty much closed in the next session.

@kelpiemsp Hi i hope you can Tell me based on your trial, how long do you have yo stay in Minnesota to take part in the trial?

I suffered an acoustic trauma on March 7, 2015. Since then been living with tinnitus. The first month was the worst. I went through the whole process we all go through, why me, a lot of crying, anxiety, loss of sleep and suicidal thoughts. Joined the AM-101 program, went to three rounds...

The earliest in my humble opinion from everything that is going on currently maybe in five years and if only everything runs perfectly (meeting or exceeding expected results in each phase).

although not mention directly in the article, the process for hair cell regeneration falls into the regeneritive or RMAT (regenerative medicine advanced therapy) designation. Hopefully this will speed up the process for freq tx and other companies.

dont trust phone decibel meters, if you can fully understand an speak to a person 2 feet away from you (normal conversation volume), then you should be ok. If you have to shout to be heard then run away or wear plugs next time.

Already has been done in AM 101. If you did only the first set of injections you had no idea if you received esketamine or not

..."Although a number of studies have explored the potential of supporting cells as precursors for mitotic hair cell regeneration after damage, a limited degree of proliferation of supporting cells and mitotic hair cell regeneration in response to damage was observed in neonatal cochlea only...

Turning blue and looking like a smurf is ok but a lot of floaters (a little bit like i have now since i stop taking trobalt is ok) or visual snow is not a small price. If you are going to take it, taper up easily and at the first signs of visual problems stop. In my case was after 2 months and...

Evolution is a bitch there is a reason for why the regeneration of hair cells is stop in mammals and it might have something with the fidelity of human hearing. Who knows i guess thats why frequency has not injected any one yet.

That is correct, some researchers are worried about the role that supporting cells migth play in the hearing of mammals and therefore what kind of hearing you will get after you lost the supporting cells in the procedure. As i understand it frequency approach uses the supporting cells without...

"Here, we demonstrate that human LGR5+ colorectal cancer cells serve as CSCs in growing cancer tissues." I think its actually referring to LGR5+ in already form colorectal cancer not the one present in normal colon and rectum tissue. Just my interpretetion.

1st Order Pharmaceuticals http://www.1storderpharma.com 1st Order Pharmaceuticals (1OP) is a development-stage pharmaceutical company focused on advancing its drug, 1OP-2198, a clinical stage Kv7.2/Kv7.3 opener in epilepsy and pain. It also has a discovery program for parenteral administration.

@Mricha37@linearb Hi, i got a pair last year and at least for me they work pretty well. They allow me to graduate the level of attenuation that i want so i can hear well other people while wearing them. I use them at the movies and social gatherings where there might be high music in the...

@dj_newark I also had side effects but only visual and after a few months of use. I did get floaters which have 90% gone away after leaving trobalt. I never had anything of that sort that you had, confusion yes high and happy yes but no convulsions. I guess everybody react differently i am...

Done and i will buy it in a heartbeat hope that it has some memory so you can check the loudest you have been exposed say in the last hour

@Alue Good to hear that it help you . I had more or less the same account of events as you. Acoustic trauma and am 101 then trobalt. Took it for maybe 5 months out total up to 300 tid but usually on average 200 mg tid. Left it because of floaters. Its not a cure but it defineatly makes...

it was worst while taking the drug once off it they become less and less evident with time to almost none existant (have to look for them). Visual acuity is back to what it was before trobalt (i suspended it over a month ago). I never had visual snow just floaters.

I use it occasionally and it lowers it considerably sometimes for hours with one pill. The problem is the nasty side effects in my case floaters and visual acuity ( they become less and less noticeable while not on trobalt). Its not placebo as i once commented it probably has to do with the...

I still take 200 mg ocasionally ( one time a day for two weeks and then maybe two to three weeks off) it does help to make my tinnitus more manageable without so many side effects). When i take it, its effect is variable, sometimes it gives me hours of profound relief (4 to 5 hours), sometimes...

Yes quite true it clearly states that it might be a treatment for acute damage before the hair cell permanently died ( i think its about 4 to 7 days after trauma)

@glynis thanks for your kind words. In spite of all I am trying to be positive about the future. I am getting better or habituated however they want to call it and the future is no longer dark as before. Thankfully they were no children involved since my wife has problems (imagine the irony) I...

@Zora no my tinnitus is not severe as a matter of fact with time it is been getting better. It just that it really changes you. I was a very outgoing funny joker guy and it has turn me inwards and a little bit anti social. I don't like to go to friends gathering since there is always music...

NOT. My wife of seven years just divorce me. Guess my tinnitus got to her. Well better to find out the type of person she was. Imagine if I had been hit by a truck and left paralysed, I would had have to clean my own poop for life. Well everything happens for a reason

@Kyxwz Maybe two months

No visual snow, nor visual interference. I had plain all floaters after goiong upwards of 800 mg per day (divided in three dosages of course). They are basically 90% gone since reducing my intake of trobalt just to temporary use of 200 mg of trobalt. Once a day when only it goes up and gets a...

in my opinion trns sounds at least as promising and less invasive. (transcranial electrical random noise stimulation).

@monacco hope it goes well for you, keep us posted. A complete journal of your experience with stem cell, would be greatly aprecciated.

Sounds like meniere's disease

@Hopeful1 not really

they are conducting post acute studies along side the acute trial, so we would have to wait for the results.

two months after acoustic trauma first round Placebo or Drug five months into acoustic trauma second set of injections real drug so you see i was as acute as they can be

@Kyxwz I also suffer from acute acoustic trauma. Did two rounds of am 101 *at least the second round was the real drug* and it did not to anything for me. So dont feel sad. There are some story of people getting better but al least in this forum the majority from what i have gather and heard...

@Twitch 79 kilos. Also i found during my trial that combining neurontin with retigabine gave at least three days of almost complete silence before it came back to what it was before the combo. After that it made no difference the combination so i stop taking it and after a month try again...

RL-81 love the new name it is good news but if it's still in animal studies I will take a long time to get out to the public if at all, but it's good to know that they are still working and even improving on sf0034. Thanks for the share @lymebite

@AlexSongitus The webpage you posted for the tone generator seems to be helping to turn the tone tinnitus that i have left off and make it dissapear for at least a few minutes. Do you by any chance now the protocol and how to use it. Do you listen to it all day or only for a few minutes? and...

Josue it sounds that you have an acoustic trauma to the ear like i had. I myself also had a weird cold one week before my trauma happen. First all try to remain calm. Its very recent and it could go away by its own, plus you are a young guy and that helps. STAY AWAY from loud sounds and do...

In my experience it is very useful at onset of tinnitus. When i had my acoustic trauma i spent almost 7 days without sleep and anxiety and depression made everything 10 times worst. I took clonazepam and managen to take a few good nights of sleep and it made a whole world of difference. Only...

Patrick I reported also all of these during my last month of taking trobalt and that is why I stop. In your case it is very worrisome that your vision became black from the periphery to the center because that can be a sign of retinal dettachment. About the snow and the floaters I think that...

No one will be able to answer that question since there has been no studies. In my opinion and i repeat in my opinion with no scientific bases, it will probably not affect any natural recovery going on.

@Neilpk the theory is to protect your ears without the neccesity of using earplugs. Right now at least in my case fi i put a earplug protection or my finger into the canal it protects me but increases my tinnitus sensation just as yours is noticible at nigth (silence). So if this works i...

I already order mine from doppler labs, they are supposed to ship on march. My tinnnitus is under control at a 2 sometimes less. I am ordering to use them all day and therefore protect my hearing without the currents plugs that i have now that increase my tinnitus sensation. I will post my...

My mistake did not read the entire thread before responding

As I posted before the only dermatologic study I found in the Internet found that the blue tone subsided completely after 4 month of stopping trobalt. Are you still on it or did you stop, and if you stop how long ago?

Trobalt and aut0063 are completely different drugs and affect completely different parts *the same channels different parts*. I think you need to know that Joan. No one has made a trial in humans with trobalt for tinnitus (yes for epilepsy no for tinnitus). SF00034 would be the equivalent to...

that definetly is a possibility but if it was like that it surely help me habituate because in the first week of trying it up to 600 mg a day it when from 7 to 0 the major part of the day and finally stay at a 2. No cure but it sure help somehow specially in recent T. Right now about two...

Progress Report Progress Report Date: Feb 2, 2016 Current Retigabine Dosage: 0 Current Side Effects: none Current Tinnitus Severity: 2 out of 10 Changes in Tinnitus: I started trial on august 17 approximately. Stop two times for a week because i ran out of trobalt. Took it continuosly...

Dosages are to low you should built up 150 mg per week to 600 and 1200 mg daily (therapeutic range for epilepsy). Before someone tells me anything I did trobalt from August 17 to December 17 2015. Stop in between for about week and half because I ran out of trobalt. Finally stop in December...

You mean gone for a few days or you just took it and so far in this few hours it has gone down??????. You have to be a little more specific

As always i agree with you its good to have both point of views so that people can make the right desicion for themself.