AM-101 Possible Treatment for Ear Hyperacusis?

As a lot of you may know by now, I've been suffering with varying degrees of tinnitus since 2011.

As of the last few months I began noticing pains in my neck and shoulder that came and went at random after a sudden noise exposure.

At first I put it down to stress and tension and after a visit to my doc I was reassured it was just that, given Diazepam 4mg daily and hey presto I was ok again, that was until late January when the pain returned and stayed and over night my tinnitus worsened seven fold and then came along extreme hyperacusis.

It's now been confirmed that the pain is indeed coming from my ears and spreading into my neck and back.

After a chat with my specialist whose heavily involved with UCL and a hearing test that showed a poor response of outer haircells in my left ear although this has been deemed inconclusive as my ear muscles are tightening to nearly every sound[TTTS] and may be skewing the results, I put it to him about the possibility of AM-101 being used to treat hyperacusis also?

As we know AM-101 is basically Esketamine, a well known anesthetic that works on NMDA receptors to block pain signals being sent to the brain and after reading the latest research on hyperacusis there appears to be pain nerve cells in the inner ear also.

I have spoken to a few individuals with hyperacusis who received a Lidocaine injection and hey presto their hyperacusis was gone.

Whether it was permanent or not I do not know but this would indicate that AM-101 could be hugely beneficial to hyperacusis patients.

I'm considering getting the drug as my specialist may be able to get me into the trial with of course Auris knowing that I've had extremely mild tinnitus up until two weeks ago.

I'm expecting a call from them tomorrow but I would like a few opinions on this before I go ahead and do it.

Bill

 

I think I read an article on newspaper where a guy on AM-101 saw disappeared his T & his H !

I will make the trial next month...

 

Aren't you doing Trobalt as well at the moment? Don't think that's allowed when doing the trial or is it?

 

I will stop trobalt and make a fast tapper or avoid AM-101, I didn't make my choice

 

Got the same issue stay at trobalt or do am 101 as well...

 

@Bill 122, you mentioned you've heard lidocaine injections helped people with H. Do you know where the injection site was?

 

Hi Briann a local woman near me had suffered with T and H for years after an ear infection ruptured inwards,she went to see her Neurologist one day and told him about the T and H and he decided to give her a Lidocaine injection into her neck.Her T disappeared for hours and she remains H free to this day,Ive done some research on Google to see if anyone else had such success and came across a very similar story on an old H chatroom.

 

Got it. Thanks.

 

At the chat-hyperacusis.net forums there was a user calld cbBen who, if I recall correctly, also hade lidocaine injections and got T and H free but it only lasted until the next sound incident.

Did a search on lidocaine over there and most of the stuff about it is written by that user. Here's one thread about it:

http://www.chat-hyperacusis.net/pos...lly-was-lidocaine-2440486?highlight=lidocaine

 

That's not so bad !

 

Well his T and H came back so it was not a cure, just temporarily relief so I wouldn't really agree with you.

 

That depends what you call "sound incident", if the deal is take lidocaine no more T+H except if you go to a concert/club/diving...I sign today for lidocaine !

 

Hey Lapidus I also done a search over there but couldnt find where he states that his H had returned?His T did but the last message where he mentioned his H he states that he had been H free for 3 days and then nothing after that?Also he has since deleted his account?Weird but who knows maybe he was cured and decided to leave the forum?

 

You have to look at more than just that thread. He's written tons of posts on that board and if you do a search on lidocaine on there you'll find lots of threads he has posted in. If I recall correctly, his H returned due to a cinema visit. His account is not deleted but he does not post there anymore due to disagreements with Rob and Dan etc.