Desensitizing Nicotinic Agents Normalize Tinnitus-Related Inhibitory Dysfunction

[MJHaze]

I only scanned over this as it is too complicated for me to understand, but it appears promising as it seemed to have had some effect on mice with noise-induced tinnitus.

Conclusion
Collectively, tinnitus-related loss of nAChR signaling in A1 layer 5 PNs and increased responses to nAChR signaling in VIP neurons may, in part, underpin pathological attentional deficits in tinnitus subjects. Sazetidine-A and varenicline normalized tinnitus-related losses of inhibitory input onto layer 5 PNs likely via desensitization of nAChRs located on VIP neurons. In behavioral studies, both sazetidine-A and varenicline decreased the psychophysical evidence of tinnitus in our animal model.

→ Sazetidine-A and varenicline may decrease tinnitus by increasing the activity of inhibitory input neurons

 

[Nick47]

Varenicline is Champix — a smoking cessation aid.