Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development

Niklas · Oct 12, 2016

abstract
Subjective tinnitus is the perception of sound in the absence of external or bodily-generated sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in Europe. A wide variety of comorbidities, including hearing loss, psychiatric disorders, neurodegenerative disorders, and temporomandibular joint (TMJ) dysfunction, have been suggested to contribute to the onset or progression of tinnitus; however, the precise molecular mechanisms of tinnitus are not well understood and the contribution of genetic and epigenetic factors remains unknown. Human genetic studies could enable the identification of novel molecular therapeutic targets, possibly leading to the development of novel pharmaceutical therapeutics. In this article, we briefly discuss the available evidence for a role of genetics in tinnitus and consider potential hurdles in designing genetic studies for tinnitus. Since multiple diseases have tinnitus as a symptom and the supporting genetic evidence is sparse, we propose various strategies to investigate the genetic underpinnings of tinnitus, first by showing evidence of heritability using concordance studies in twins, and second by improving patient selection according to phenotype and/or etiology in order to control potential biases and optimize genetic data output. The increased knowledge resulting from this endeavor could ultimately improve the drug development process and lead to the preventive or curative treatment of tinnitus.
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https://www.ncbi.nlm.nih.gov/pubmed/27594824

MikeP505 · Oct 12, 2016

A post that may or may not be reliant here. Just the same, great minds are working towards a treatment or cure.

http://hearinghealthfoundation.org/blog?blogid=251

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Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development

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Genetics of Tinnitus: An Emerging Area for Molecular Diagnosis and Drug Development

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Niklas Member Benefactor

MikeP505 Member Benefactor

Genetics of Tinnitus: Time to Biobank Phantom Sounds

What Are the Mechanisms Behind Muscle Stiffness Causing Tinnitus?

Tumor, Tinnitus, Depression, and the Journey Back to Life (Moscow, Russia)

Has Anyone Had Their Tinnitus Turn Into a High-Pitched Hissing?

Sound Sensitivity and Tinnitus After Craniotomy for Epidermoid and Cochlear Fistula

Share This Page