Here's a Safe Benzo Drug for Tinnitus Sufferers: Tofisopam (Emandaxin, Grandaxin, Sériel)

[peter91]

If you have anxiety and want a safe benzo without potential for addiction/withdrawal, there's Tofisopam (Emandaxin, Grandaxin, Sériel).

I used it for 2 weeks with somewhat good results.

I actually have no idea why it's not widely used because its effect is good and it's safe.

Just wanted to let you know.

 

[GBB]

If you have anxiety and want a safe benzo without potential for addiction/withdrawal, there's Tofisopam (Emandaxin, Grandaxin, Sériel).

I used it for 2 weeks with somewhat good results.

I actually have no idea why it's not widely used because its effect is good and it's safe.

Just wanted to let you know.

Why do you think this is safer than any other benzo? As someone who responds strongly and would love to be on a benzo (Xanax basically makes my tinnitus a non-issue), curious on your logic here.

 

[OnceUponaTime]

I used it for 2 weeks with somewhat good results.

What was your dosage and why did you stop taking it?

 

[FGG]

Why do you think this is safer than any other benzo? As someone who responds strongly and would love to be on a benzo (Xanax basically makes my tinnitus a non-issue), curious on your logic here.

https://en.wikipedia.org/wiki/Tofisopam

The wiki says it is "safer" but still has potential for withdrawal. I just did a superficial search. I haven't looked into it more.

 

[GBB]

https://en.wikipedia.org/wiki/Tofisopam

The wiki says it is "safer" but still has potential for withdrawal. I just did a superficial search. I haven't looked into it more.

"Tofisopam is 2,3-benzodiazepine, unilke tradiconal benzodiazepines it does not bind to the benzodiazepine binding site of the GABA A receptor. It does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. It also been found that it is PED inhibitor which may play role in cognitive improvement. And it does something with dopamine receptors."

From someone more knowledgeable than me - so not sure it would have any effect on tinnitus directly.

 

[peter91]

What was your dosage and why did you stop taking it?

100mg / day.

After cocaine, I got some gut issues. I mean, lately I can't even drink coffee without a feeling of discomfort. Unfortunately, I had abdominal pain from Grandaxin. Still looking with doctors why.

Why do you think this is safer than any other benzo? As someone who responds strongly and would love to be on a benzo (Xanax basically makes my tinnitus a non-issue), curious on your logic here.

I actually used it and quit CT without any kind of discomfort (though some psychotherapists suggest tapering, but not as slow as Xanax). Also, my psychotherapist told me it's not comparable in terms of dependence to traditional benzos (Xanax, Lorazepam etc etc) and one could take it safely up to 3 months.

"Tofisopam is 2,3-benzodiazepine, unilke tradiconal benzodiazepines it does not bind to the benzodiazepine binding site of the GABA A receptor. It does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. It also been found that it is PED inhibitor which may play role in cognitive improvement. And it does something with dopamine receptors."

From someone more knowledgeable than me - so not sure it would have any effect on tinnitus directly.

I felt some positive difference in tinnitus, but maybe it's because of the anxiety levels dropped.

 

[GBB]

100mg / day.

After cocaine, I got some gut issues. I mean, lately I can't even drink coffee without a feeling of discomfort. Unfortunately, I had abdominal pain from Grandaxin. Still looking with doctors why.

I actually used it and quit CT without any kind of discomfort (though some psychotherapists suggest tapering, but not as slow as Xanax). Also, my psychotherapist told me it's not comparable in terms of dependence to traditional benzos (Xanax, Lorazepam etc etc) and one could take it safely up to 3 months.

I felt some positive difference in tinnitus, but maybe it's because of the anxiety levels dropped.

Thanks - definitely appreciate the response!

 

[Jack Straw]

"Tofisopam is 2,3-benzodiazepine, unilke tradiconal benzodiazepines it does not bind to the benzodiazepine binding site of the GABA A receptor. It does not have anticonvulsant, sedative, skeletal muscle relaxant, motor skill-impairing or amnestic properties. It also been found that it is PED inhibitor which may play role in cognitive improvement. And it does something with dopamine receptors."

From someone more knowledgeable than me - so not sure it would have any effect on tinnitus directly.

This seems to strange. It is a benzo, but is a different kind that doesn't have the sedative effect? Does it have a dependence issue like other benzos?

 

[linearb]

This seems to strange. It is a benzo, but is a different kind that doesn't have the sedative effect? Does it have a dependence issue like other benzos?

Well, it's super weird. Structurally it's a benzo, but it doesn't actually bind to the benzo receptor, and it seems to potentiate some BDZ drugs but not others?

Because this is something which is mass produced overseas as a pharma drug but is not used or controlled here, it is super easy to obtain online.

I will leave that to the more intrepid, since my daily Klonopin keeps me good, but I look forward to what anyone has to say about this. On the other hand, weird anxiolytic drugs from Russian markets are a dime a dozen and most of them are useless.

 

[peter91]

This seems to strange. It is a benzo, but is a different kind that doesn't have the sedative effect? Does it have a dependence issue like other benzos?

Yes, no sedative effect. Rather energizing a bit.

Dependence isn't that strong if one keep take it up to 3 months. I mean, you can't compare dependence of traditional benzo to it, no way.

Well, it's super weird. Structurally it's a benzo, but it doesn't actually bind to the benzo receptor, and it seems to potentiate some BDZ drugs but not others?

Because this is something which is mass produced overseas as a pharma drug but is not used or controlled here, it is super easy to obtain online.

I will leave that to the more intrepid, since my daily Klonopin keeps me good, but I look forward to what anyone has to say about this. On the other hand, weird anxiolytic drugs from Russian markets are a dime a dozen and most of them are useless.

Agree, it's weird. But this is how it is.

It is not useless but not as strong as Xanax. Rather like Atarax (Hydroxyzine).
Also, it has some positive effect on cognition, rather than making memory worse as other benzos.

About safety -- as far as I know it's really safe (if you compare it to Hydroxyzine).

 

[Jack Straw]

Yes, no sedative effect. Rather energizing a bit.

Dependence isn't that strong if one keep take it up to 3 months. I mean, you can't compare dependence of traditional benzo to it, no way.

Agree, it's weird. But this is how it is.

It is not useless but not as strong as Xanax. Rather like Atarax (Hydroxyzine).
Also, it has some positive effect on cognition, rather than making memory worse as other benzos.

About safety -- as far as I know it's really safe (if you compare it to Hydroxyzine).

Do you take this everyday or as needed?

 

[peter91]

Do you take this everyday or as needed?

Supposed to be taken daily. I took it daily. However one can take it situationally, e.g. before/after stress.

 

[Turgy]

where can I buy it?

 

[peter91]

where can I buy it?

In my country at any Pharma shop provided you have prescription for it. You can search over the internet. But I would strongly suggest checking if it is legal to buy this online in your country (it's a prescription benzo drug mate!!)

 

[Jack Straw]

In my country at any Pharma shop provided you have prescription for it. You can search over the internet. But I would strongly suggest checking if it is legal to buy this online in your country (it's a prescription benzo drug mate!!)

You don't need a doctor to prescribe it where you are from?

Keep us updated as to how it goes!

 

[peter91]

You don't need a doctor to prescribe it where you are from?

Keep us updated as to how it goes!

In my country you still need a doctor to prescribe it.

But you know, if you really want... you can get almost anything...

 

[Chinmoku]

There is a Japanese study for tinnitus but in the context of dysautonomia and apparently low pitched:

https://www.jstage.jst.go.jp/article/jibirin1925/82/1/82_1_133/_article

Clinical Evaluation of Tofisopam in the Treatment of Tinnitus

Abstract
Our previous reports dealt with tinnitus and impaired hearing as autonomic dysfunction in the field of otorhinolaryngology. In 46 patients, tinnitus without hearing loss or with impaired hearing of low-pitched sounds was the manifestation of autonomic dysfunction, as diagnosed by Schellong's test and T. M. I. These patients were treated orally with Tofisopam 150mg daily (50mg three times a day), and changes in the severity of tinnitus were monitored. The treatment was markedly effective or somewhat effective in 32 (70%) of the 46 patients. Schellong's test done at intervals of 2 weeks became negative in 70% of the 20 patients. These results indicate that Tofisopam is effective in the treatment of tinnitus.

 

[GBB]

There is a Japanese study for tinnitus but in the context of dysautonomia and apparently low pitched:

https://www.jstage.jst.go.jp/article/jibirin1925/82/1/82_1_133/_article

Clinical Evaluation of Tofisopam in the Treatment of Tinnitus

Abstract
Our previous reports dealt with tinnitus and impaired hearing as autonomic dysfunction in the field of otorhinolaryngology. In 46 patients, tinnitus without hearing loss or with impaired hearing of low-pitched sounds was the manifestation of autonomic dysfunction, as diagnosed by Schellong's test and T. M. I. These patients were treated orally with Tofisopam 150mg daily (50mg three times a day), and changes in the severity of tinnitus were monitored. The treatment was markedly effective or somewhat effective in 32 (70%) of the 46 patients. Schellong's test done at intervals of 2 weeks became negative in 70% of the 20 patients. These results indicate that Tofisopam is effective in the treatment of tinnitus.

I'm kinda looping back to consider this. Xanax literally saves my ass - if I could use something more liberally that had fewer issues, I would love to. That being said I know this is less potent than Xanax as it binds to fewer receptors, so I'd be really curious to see how it affects my tinnitus if at all. If it did have an effect on tinnitus, pairing it with an anxiolytic like CBD would be easy.

Xanax sort of has the effect on my tinnitus people seem to describe in the positive Lenire reviews - the sound is still there but so much more tame and soft - functionally I don't really mind it so it's as if I'm cured.

 

[Chinmoku]

I'm kinda looping back to consider this. Xanax literally saves my ass - if I could use something more liberally that had fewer issues, I would love to. That being said I know this is less potent than Xanax as it binds to fewer receptors, so I'd be really curious to see how it affects my tinnitus if at all. If it did have an effect on tinnitus, pairing it with an anxiolytic like CBD would be easy.

Xanax sort of has the effect on my tinnitus people seem to describe in the positive Lenire reviews - the sound is still there but so much more tame and soft - functionally I don't really mind it so it's as if I'm cured.

Definitely worth looking into, you might stumble into a lucky combination. I wish CBD worked for me. It spikes my tinnitus

As for benzos the jury is out on whether GABA drugs have contributed to make my tinnitus the agony it currently is. This one looks quite different though.

 

[Greg Sacramento]

@Chinmoku Several things that I mentioned to you are also discussed in this article:

Auditory Neural Plasticity in Tinnitus Mechanisms and Management

 

[Chinmoku]

@Chinmoku Several things that I mentioned to you are also discussed in this article:

Auditory Neural Plasticity in Tinnitus Mechanisms and Management

Thank you Greg. I have saved it in my laptop folder. At the moment I'm too distressed to read but I'll try in the evening when I can tolerate this horrid electric signal a little better.

 

[peter91]

Bumping this thread.

Did anyone try this already?

@Chinmoku
@GBB

P.S. I had GERD so that's why benzos are not a choice for me (and they also discontinued this product).

 

[Dolgoruki]

Anyone tried this already?

 

[Chinmoku]

No I didn't try it. I'm still on Clonazepam

 

[IntotheBlue03]

Hi all. I have been prescribed Clonazepam but haven't taken it. I hate medications that impair my motor skill wise or cognitively so it's very unfortunate that my Type A personality now endures severe tinnitus. I browsed the study and what's interesting for me is I've been diagnosed with POTS and have normal hearing. I'm inclined to look into this over the Clonazepam.

Have you found anything more recent than this study @Chinmoku?

@GBB, @peter91, did this have any effect on your tinnitus?

 

[IntotheBlue03]

Just reporting back for anyone interested. I've been taking Grandaxin 2-3x daily at 50 mg and it cut my tinnitus in half. I have centralized high frequency (14-15 kHz) oscillating reactive tinnitus so for me it has been severe. No side effects besides a slight headache the first week and I do like that it is non-intoxicating for the most part.

I shudder to think I'm in the Schulman camp but am taking this to avoid that potential fate for now.

 

[Ben Johnson]

@IntotheBlue03, how is the Grandaxin working out for you? I'm 3 weeks into tinnitus hell and I've taken .5 mg Klonopin once and it helped a lot but I feel like it's a band aid. Looking for other less addictive options. Thanks.

 

[IntotheBlue03]

@IntotheBlue03, how is the Grandaxin working out for you? I'm 3 weeks into tinnitus hell and I've taken .5 mg Klonopin once and it helped a lot but I feel like it's a band aid. Looking for other less addictive options. Thanks.

Hey @Ben Johnson, it cuts my tinnitus in half and definitely takes the edge off anxiety wise. It is non intoxicating I definitely recommend it. I'm still having some panic issues but working on that.

 

[Ben Johnson]

@linearb, I read where you said you take Klonopin and it keeps you good. I just got tinnitus and have noticed when I take .5 mg of Klonopin it really helps me cope. I've only taken it a couple of times as I'm afraid of the dependency issue.

My mother has been taking 4 mg of Clonazepam a day for 20 years for A & D and she does great.

Do you mind if I ask your Klonopin dosage and how long you've taken it? Have you had to steadily increase the dose? Any information would be helpful. I'm also considering asking my psych about Grandaxin, SSRI, SNRI, etc.

Thanks a bunch!

Ben

 

[Ben Johnson]

Hey @Ben Johnson, it cuts my tinnitus in half and definitely takes the edge off anxiety wise. It is non intoxicating I definitely recommend it. I'm still having some panic issues but working on that.

That's great! I'm going to ask the doctor about it. These first few weeks have been the toughest of my life. On one hand, I want to take meds to deal. On the other, I don't want the meds hindering habituation... I have C2/C3 problems in neck which has been causing non-stop tension headaches leading up to this tinnitus hell. I'm considering weekly neck massages but that may be fool's gold. I'm a candidate for surgery but that might open a whole new can of worms.