Injectable Polyplex-Loaded Glycol Chitosan Thermogel for Efficient and Safe Inner Ear Gene Delivery

[Frédéric]

Yet another team is trying to solve the inner ear delivery issue.

Injectable polyplex-loaded glycol chitosan thermogel for efficient and safe inner ear gene delivery

Highlights

• A novel RH-PAMAM G2 polyplex-loaded HGC thermogel system has been designed to enable effective gene delivery to the inner ear.
• RH-PAMAM G2 exhibited excellent gene delivery efficiency into HEI-OC1 cells.
• RH-PAMAM G2 polyplex/HGC thermogel formulation enabled prolonged delivery, targeted gene delivery, resulting in more distribution of anti-GFP in the cochlea tissue.
• This formulation holds strong potential as a promising therapeutic approach for otic gene therapy.

 

[Gorbeh3]

Everyday, step by step.

Hang in there, boys.

 

[Joeseph Stope]

This could be very important. Now, all we need to do is go back and test those failed pharmaceutical and biopharmaceutical candidates using this new delivery method.

All you tinnitus punters out there, get yourselves on the list for the upcoming trials! I am volunteering for the placebo group, so at least we will know that one will not work anyway. Just joking!

Hats off to the Korean researchers who took the time and effort to examine and improve the delivery method. This aspect seems to have been neglected in the past. Who knows? The delivery method might even need to be tailored for each specific drug.

At least we can now be reassured that medical research does not begin and end with the US FDA approval process or rely entirely on Elon Musk or Donald Trump.

 

[Nocca]

If I may join this thread, there is also a French team working on inner ear drug delivery (not gene therapy) using sonoporation (microbubble-assisted ultrasound).

They wrote a review article in 2023, "Microbubble-assisted ultrasound for inner ear drug delivery".

Highlights

• Strong medical need to deliver therapeutic agents to the inner ear.
• Sonoporation is an easy, promising, and safe modality.
• Optimized parameters allow for greater therapeutic efficiency.
• Sonoporation provides new possibilities to treat inner ear pathologies.

One of those researchers, David Bakhos, received a grant in 2024 from the French Fondation de l'Audition to keep on researching such techniques for the next three years.

(@Frédéric, I "copied" the style of your post, but it's very efficient and a good way to summarize articles!)