KCNQ2/3 and HCN Channels Underlies Vulnerability and Resilience to Tinnitus

Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

 

@Nick47, @StoneInFocus, I know this is an old thread but I wanted to get your opinion on what you reckon is causing hyperacusis/noxacusis; Kv potassium channels or HCN channels.

I saw you were discussing the Prof. McNaughton study on using Ivabradine to open HCN2 channels in Guinea Pigs with success.

Two Kv potassium channel drugs are currently in clinical trials: BHV-7000 and XEN1101, with XEN1101 in their Phase 3 trial and with BHV-7000 starting their Phase 2/3 pivotal phase trial later this year.

Other than Ivabradine and Merck2, which is still in preclinical, are there any other HCN drugs in clinical trials or any natural remedies that can target HCN2?

 

Both seem to be the answer as these ion channels in the cell membrane change the action potentials of the cells.

I'm not aware of any other candidates around.

This is a slightly more recent summary. It mentions the importance of selectivity in HCN channel blockers:

Oxford Talks: HCN2 ion channels – drivers of chronic pain and tinnitus