Ketamine Injection

[Sylvia Koch]

Hello! My name is Sylvia, I'm a musician and new to this forum. I got my T back in December of 2015 from a loud noise exposure and have been struggling with it for a while now. However, during the day my T is pretty mild/ mostly whooshing in my left ear/a little ringing in the right that isn't noticeable until later in the day when it gets worse.

I've been doing my research on AM 101 and unfortunately didn't make the cut. I know that the drug used in the trials is esketamine, but I was wondering....what would the effect of Ketamine be if injected into the inner ear? Not esketamine, but just plain Ketamine. If you had the chance to get an injection of Ketamine, would you? Do you think it would help? Just curious.

Cheers guys.

 

[Aussie Lea]

Hello! My name is Sylvia, I'm a musician and new to this forum. I got my T back in December of 2015 from a loud noise exposure and have been struggling with it for a while now. However, during the day my T is pretty mild/ mostly whooshing in my left ear/a little ringing in the right that isn't noticeable until later in the day when it gets worse.

I've been doing my research on AM 101 and unfortunately didn't make the cut. I know that the drug used in the trials is esketamine, but I was wondering....what would the effect of Ketamine be if injected into the inner ear? Not esketamine, but just plain Ketamine. If you had the chance to get an injection of Ketamine, would you? Do you think it would help? Just curious.

Cheers guys.

Where do you live? Can you say who doctor does ketamine injections to ear?

 

[Sylvia Koch]

Where do you live? Can you say who doctor does ketamine injections to ear?

I'm from Illinois, I don't know of a doctor who can do it, I'm simply curious if anyone thinks this could work/the differences between esketamine and ketamine and its effects on the inner ear.

 

[Mario martz]

I Think they are kind of different...
but i do wonder the same...
as far as i know Ketamine is a strong drug

 

[bill 112]

Who knows is the simple answer I guess,everything is experimental at this stage so your guess is as good as any.

 

[linearb]

I don't think you're going to be able to find anyone willing to do transtympanic injections of ketamine, because I don't think it's ever been tested or approved. The main advantage of AM-101 is that it's a proprietary gel which dissolves slowly; if you just injected ketamine into your ear, it would be absorbed and then wear off rather quickly.

I've seen clinical speculation that the etiology of tinnitus (at least in some cases) be relatable to the etiology of Complex Regional Pain Syndrome. Because certain IV ketamine protocols have been shown to have a positive impact on CRPS, it would be interesting to know what effect those same protocols would have on tinnitus patients... something no one has attempted to study, as far as I know.

 

[Frederico_23]

Anynone tried?

http://www.laboratoryequipment.com/...g-ketamine-may-treat-depression-ptsd-tinnitus

http://www.ketamineclinics.com/

 

[daniel1111]

Anynone tried?

http://www.laboratoryequipment.com/...g-ketamine-may-treat-depression-ptsd-tinnitus

http://www.ketamineclinics.com/

I've tried Ketamine, ok not for this purpose, but anyway it had no effect on it long term.

While on Ketamine, and in the hours after it, tinnitus was there to an extreme level, but that seems common for dissociatives anyway.

I don't think injecting it into the ear would be a good idea. Obviously they've put a lot of research into finding the exact enantiomer they think may help, and at that reports so far seem to be inconclusive as to whether it actually does or not. Randomly injecting other isomers or enantiomers and hoping for the same result is really illogical to me, but what do I know I'm not a chemist or doctor!

 

[PeterD1361]

Hello community,

I've read similar posts on here, but just curious, it seems that there has been SOME positive results for AM-101, and many of the drugs in development (OTO-311, etc) all seem to be pointing toward these NMDA receptor antagonist theories. Are any doctors you know of experimenting with esketamine intratympanic injections? Im not talking about through a trial....I'm just asking through their own practice? I would be curious if any of the key researchers involved with any of these trials have been doing this on their own, or would be open to it? Seems worth an obvious try. These trials are all very well tolerated and safe.

Curious if anyone knows of anyone doing this? I've thought about reaching out directly to some of these lead researchers.

Thanks so much!
Sincerely, Peter

 

[Karrie]

What about Ketamine IV treatment for tinnitus? I have seen it advertised for pain and depression treatment. Karrie

 

[Mic]

What about Ketamine IV treatment for tinnitus? I have seen it advertised for pain and depression treatment. Karrie

They listened to you Karrie...

New trial in New York started by New York State Psychiatric Institute. More info @ https://clinicaltrials.gov/ct2/show/NCT03336398?recrs=abdfm&cond=tinnitus&draw=3&rank=28

P.S.: Anybody any experience with this stuff??