Megan Beers Wood Research Updates / Discussion: Cochlear Inflammation & Pain Hyperacusis Mice Model

I wanted to make a separate thread for discussing the subject of cochlear inflammation, its relation to pain hyperacusis, and Megan Beers Wood's research. Here is my latest mail exchange with her (omitting the usual formalities):

 

Thank you for this information @StoneInFocus.

Does Megan Beers Wood's study correspond to Paul Fuchs' work? I assume it's the same team?

In one of his first studies Arnaud Norena mentioned this:

Could the CGRP gene studied by Megan Beers Wood in the inner ear be identical to the one found in the middle ear?

The best thing would be to have drugs in the future to alleviate this pain.

 

Wood and Fuchs have worked on some papers together before (see for example attached). I think you could see Wood as Fuch's protégé. In the past few of their papers they have investigated cochlear noxacusis mechanisms. They believe cochlear inflammation to be a possible factor in painful hyperacusis.

I'm not really knowledgeable in that regard, maybe I'll read his papers more carefully in the future.

 

Has anyone tried this new Biohaven drug yet?

It's a new-generation molecule that antagonises the peptide linked to the calcitonin gene.

 

In case you haven’t come across this thread yet already, it’s discussed here:

Rimegepant for Treatment of Migraine and Phonophobia (Hyperacusis?)

Looks like someone has tried it for loudness hyperacusis, but it had no effect.

 

Hello @Hazel and @Markku:

Do you think it would be possible for you to do an interview with Megan Beers Wood to find out more about this research and in particular about molecules that antagonise the alpha-calcitonin gene-related peptide (CGRPa)?

Thank you.

 

With regard to Megan Beers Wood's research, could the contractions of the tensor tympani muscle that cause pain be linked to the inner ear?

It would be interesting to know what type of symptoms correspond to Megan Beers Wood's work (inner ear) and Arnaud Norena's research (middle ear). Could the two be linked?

 

New Megan Beers Wood interview over at our friends at Hyperacusis Central.

https://hyperacusiscentral.org/interview-megan-beers-wood/