Okay so I wanted to see what alcohol's effect on the brain is because some people can lower or get rid of their T by drinking alcohol. According to Wikipedia, Ethanol does the following in the brain:
---------------------------------------------------------------------------------------------------------------------------------------------
Ethanol acts in the central nervous system primarily by binding to the GABAA receptor, increasing the effects of the inhibitory neurotransmitter GABA (i.e., it is a positive allosteric modulator).[76]
Ethanol is known to possess the following direct pharmacodynamic actions (most important actions are bolded):[77]
Notice it says the the most imported actions are GABAa receptor positive allosteric modulator and NMDA receptor negative allosteric modulator. Are there any medications out there that work on these 2 things? Also, if they do, will it make you feel like you would when you are on alcohol? I know drinking alcohol long term can be bad news and perhaps a drug like this would "poop out" over time and maybe make things worse. I know Campral works on NMDA and GABA receptors but not sure if it is a allosteric modulator because I am no chemist. If you guys know if Campral would work somewhat like alcohol let me know because I asked the doctor for it and she said it was for alcoholics not for tinnitus. For me alcohol works really weird. Somehow, atleast for now, it allows my medication to lower T again for a week or two. I have no idea why and I guess I will have to see if that effect still happens in the future. Just figured I would share this with you all.
---------------------------------------------------------------------------------------------------------------------------------------------
Ethanol acts in the central nervous system primarily by binding to the GABAA receptor, increasing the effects of the inhibitory neurotransmitter GABA (i.e., it is a positive allosteric modulator).[76]
Ethanol is known to possess the following direct pharmacodynamic actions (most important actions are bolded):[77]
- GABAA receptor positive allosteric modulator (primarily of δ subunit-containing receptors)
- Glycine receptor positive and negative allosteric modulator
- NMDA receptor negative allosteric modulator[78]
- AMPA receptor negative allosteric modulator[78]
- Kainate receptor negative allosteric modulator[78]
- nACh receptor positive and negative allosteric modulator
- 5-HT3 receptor positive allosteric modulator
- Glycine reuptake inhibitor[79]
- Adenosine reuptake inhibitor[80]
- L-type calcium channel blocker
- GIRK channel opener
Notice it says the the most imported actions are GABAa receptor positive allosteric modulator and NMDA receptor negative allosteric modulator. Are there any medications out there that work on these 2 things? Also, if they do, will it make you feel like you would when you are on alcohol? I know drinking alcohol long term can be bad news and perhaps a drug like this would "poop out" over time and maybe make things worse. I know Campral works on NMDA and GABA receptors but not sure if it is a allosteric modulator because I am no chemist. If you guys know if Campral would work somewhat like alcohol let me know because I asked the doctor for it and she said it was for alcoholics not for tinnitus. For me alcohol works really weird. Somehow, atleast for now, it allows my medication to lower T again for a week or two. I have no idea why and I guess I will have to see if that effect still happens in the future. Just figured I would share this with you all.
Member
Was his tinnitus permanently increased after the alcohol or did it go away?
