Member- Nov 28, 2017
- 760
- Tinnitus Since
- 11/2017
- Cause of Tinnitus
- noise + injury
Information presented in this post serves only for a basic orientation in the problem of tinnitus and they may or may not be either complete or relevant. It is only a mere overview of my own findings which I gathered together in the past. Your medical treatment must be under supervision of your medical doctor. I also do not guarantee that they will lead to a complete cure of your tinnitus. However, nobody can guarantee to you such a thing in the present day. Unfortunately, in this day and age there is no 100% effective way to cure tinnitus.
For noise induced tinnitus, inflammation of the middle ear, degeneration of auditory ear hair cells, insufficient neck or brain blood supply – it is imperative to start the medical treatment immediately.
It is used for tinnitus that is a result of a noise-induced trauma, middle-ear infection, degeneration of the hairs inside cochlea, insufficient neck or head blood supply. It is imperative that the treatment is started immediately. It has the same effect as the above-mentioned drugs, it is just delivered intravenously.
For noise-induced tinnitus, middle ear infection, degeneration of the hairs inside cochlea, insufficient blood supply of the neck and/or brain and the like – yet again, it is necessary to start the treatment immediately. From to afore-mentioned possible treatments this one seems to be the most effective.
On the basis of various physical processes and characteristics of each sessions comes an increased oxygen supply to the organism. The supply of oxygen may be up to 15x more increased as opposed to breathing an air oxygen under normal circumstances. The effect is in full saturation of haemoglobin, red blood cells by oxygen and particularly in many-times increased dissolved oxygen in blood plasma. As many as 4 times more of the oxygen will extend into the tissues.
For tinnitus that is localized in the middle and inner ear and is centralized in the individual parts of brain, these calm down the 'unsolicited' activity of neurons in the auditory cortex and its close parts.
The treatment is dependent on the cause of your tinnitus.
The treatment in this case isn't dependent on the cause of tinnitus
Disclaimer: I hereby declare that I do not own the rights to this article. All rights belong to the author. I am not a professional translator or interpreter so please excuse possible grammar mistakes or misinterpretations.
Author: michal from itinnitus.cz
Translation: Jiri
References:
TINNITUS – POSSIBLE MEDICAL TREATMENTS &/OR ITS ALLEVIATION – MODERN MEDICINE
Vasodilatation medication and medication to support vascular system
Vasodilatation medication and medication to support vascular system
For noise induced tinnitus, inflammation of the middle ear, degeneration of auditory ear hair cells, insufficient neck or brain blood supply – it is imperative to start the medical treatment immediately.
- Enelbin – improves blood perfusion, oxygenation and tissue nourishment
- Ginkgo Biloba – improves blood perfusion, oxygenation and tissue nourishment
- Betahistine – relaxes muscles of the vessels in the inner ear, this way there is a better blood perfusion of these vessels
- Betaserc - relaxes muscles of the vessels in the inner ear, this way there is a better blood perfusion of these vessels
- Cinnarizine lessens a tonus of lean muscles in the vessel's walls and this way it improves a supply of oxygen and glucose to the cells
- Stugeron – dampens down the effects of various hormones that cause vasoconstriction. Suppresses the onset of vessel spasms and betters the blood flow and supply of tissues including brain tissues.
- Cavinton – it is intended to use for the treatment or to dampen down symptoms connected with circulatory issues in the brain area. It is also used to affect both psychological and neurological symptoms associated with blood flow circulation problems in the brain area.
- Corticosteroids – anti-inflammatory effects.
- Microwick + corticosteroids – anti-inflammatory effects of corticosteroids are applied straight into the middle or inner ear with the help of silicone vent-tube Microvick.
Vasodilatation intravenous therapy
It is used for tinnitus that is a result of a noise-induced trauma, middle-ear infection, degeneration of the hairs inside cochlea, insufficient neck or head blood supply. It is imperative that the treatment is started immediately. It has the same effect as the above-mentioned drugs, it is just delivered intravenously.
Hyperbaric Oxygen Therapy (HBOT)
For noise-induced tinnitus, middle ear infection, degeneration of the hairs inside cochlea, insufficient blood supply of the neck and/or brain and the like – yet again, it is necessary to start the treatment immediately. From to afore-mentioned possible treatments this one seems to be the most effective.
On the basis of various physical processes and characteristics of each sessions comes an increased oxygen supply to the organism. The supply of oxygen may be up to 15x more increased as opposed to breathing an air oxygen under normal circumstances. The effect is in full saturation of haemoglobin, red blood cells by oxygen and particularly in many-times increased dissolved oxygen in blood plasma. As many as 4 times more of the oxygen will extend into the tissues.
Medication for treatment of hairs inside cochlea
For tinnitus that was caused by damaging microscopic hairs that form a fringe on the surface of each auditory cell, where vasodilatation medication, intravenous therapy, or hyperbaric oxygen therapy did not help – meaning that our body cannot help repair itself, there are specifically aimed and still under development drugs to the inner ear.
- AM 101 – 3rd. phase of testing. Also known as Keyzilen
- OTO 311 – still under development and testing
- Inception 3 – pre-clinical development
- SPI 1005 – 2nd. Phase of testing
- HPN-1010 – unknown phase of testing
- SENS 401 – 1st. phase of testing
Medication based on controlling Ion channels, and in particular potassium channel activities, antiepileptic drugs, and receptor antagonists.
For tinnitus that is localized in the middle and inner ear and is centralized in the individual parts of brain, these calm down the 'unsolicited' activity of neurons in the auditory cortex and its close parts.
- Retigabine (Trobalt, Potiga) the control of ion potassium channel activities, it was developed for epilepsy, but demonstrably works for tinnitus too, it has negative side effects
- SF0034 – controlling the Kv7.2/3 ion potassium channels, it is in a phase of testing
- AUT00063 – phase 2 testing, controlling the Kv3 ion potassium channels, primarily developed for tinnitus, in September 2015 the testing was stopped.
- Bivaracetam – phase 2 and 3 testing – it affects synaptic apertures 2A (SV2A), primarily developed for epilepsy
- Neramexan – an antagonist of NMDA receptors, during the phase 3 of testing were not achieved significant effects on tinnitus, nevertheless the tests continuous in Japan
- Gebapentine (Neurotine) – inhibition of glutamate synthesis, inhibition of release of excitatory neurotransmitters (noradrenaline and dopamine), increase in the concentration and synthesis GABA, some say it did have a positive effect on their tinnitus.
- Flupirtine – the control of the Kb7 ion potassium channels, it has a positive effect on tinnitus, however, it is important to upper intake the dosing, and with prolonged periods of time liver toxicity has been proven
- RL-81 the control of the Kv7 ion potassium channels, initiation of a pre-clinic study, it is supposed to be 15x more effective than Retigabine and 3x more effective than SF0034 and it should also has less side effects
Direct influence of a neural activity
For tinnitus that is centralized in the area of the middle and inner ear and affecting parts of brain, these methods help to calm down the unsolicited activity of neurons in the auditory cortex and its close parts.
- rTMS - repetitive transcranial magnetic stimulation
- tDCS transcranial direct current stimulation (still in the phase of testing, non-invasive)
- DBS deep brian stimulation – only intended for testing, it is invasive
- HIFU - High Intensity Focused Ultrasound – in the phase of testing on humans (the research is carried out in Switzerland and the USA, for neurosurgery it is a combination of transcranial magnetic stimulation and a high intensity focused ultrasound
Antidepressants
For the type of tinnitus that originates from the imbalance of hormones (in particular serotonin, noradrenaline, dopamine, GABA) in body (in the brain). For a different type of tinnitus, these then act as an antianxiety and antidepressive mediators.
- SSRI
- SNRI
- SARI
- others
Neuromodulation methods and a musical type of a therapy
The treatment depeneds on the reason as to how you acquired your tinnitus.
- TRT – as of now the most reliable method, it is estimated up to 90 % success rate
- ACRNM – as of now used only for one frequency tone, available in the EU
- Neuromonics – available in the USA
- Tinnitracks
- Notched Music Therapy
- Others – XinoTinnitus, Serenade, Beyond Tinnitus, UltraQuiet therapy, therapy Mozart
Nerve Stimulation
The treatment is dependent on the cause of your tinnitus.
- VNS therapy – The Serenity System – phase III of testing, the principle lies behind a stimulation of the vagus nerve and a musical therapy, it is invasive type of a treatment
- Mute Button – it is in the phase of testing, the principle lies behind a stimulation of the trigeminal nerve and a musical therapy, it is a non-invasive type of a therapy
Psychotherapy
The treatment in this case isn't dependent on the cause of tinnitus
- Cognitive behavioral therapy
- Biofeedback
- Gene therapy
- Optogenetics
- CGF166 phase 1 and 2 testing. Activation of a gene that causes the tiny hairs inside cochlea to grow again.
- SPI5557 – a preclinical study
Electronic equipment
- Tinnitus maskers
- Players
- Hearing aids – for tinnitus associated with minor, moderate and severe hearing loss
- Cochlear implant – for tinnitus when one is completely deaf
Surgical solution
- Stadeoplasty – a replacemant of the strirrup bone in certain types of otosclerosis
Disclaimer: I hereby declare that I do not own the rights to this article. All rights belong to the author. I am not a professional translator or interpreter so please excuse possible grammar mistakes or misinterpretations.
Author: michal from itinnitus.cz
Translation: Jiri
References:
- Výzkum, studie a nové metody léčby tinnitu: Tinnitus - možnosti léčby - klasická medicína. Itinnitus.cz - Diskuzní forum [online]. 7th May 2015 [cit. 2018-01-07]. Retrieved from: http://www.itinnitus.cz/forum/viewtopic.php?f=19&t=699
