Recent content by beeeep

Introduction: During the last decade, a number of candidate drugs for the treatment of tinnitus have emerged with the hope of alleviating the burden of millions of sufferers with a persisting ringing in their ears. Knowledge of the pathophysiologic mechanisms has progressed remarkably in the...

Otonomy posted their 1st quarter financial results today. I think most of the stuff in there is already known, however, it gives a nice short summary about their drug pipeline...

The results have been published: https://www.ncbi.nlm.nih.gov/pubmed/29712507 The full article is freely available, too! ;) http://journals.sagepub.com/doi/full/10.1177/0194599818767618 Sulodexide Monotherapy in Chronic Idiopathic Subjective Tinnitus: A Randomized Controlled Trial.

Only slightly interesting despite the title: Apawu AK, Curley SM, Dixon AR, Hali M, Sinan M, Braun RD, Castracane J, Cacace AT, Bergkvist M, Holt AG. MRI Compatible MS2 Nanoparticles Designed to Cross the Blood-Brain-Barrier: Providing a Path towards Tinnitus Treatment. Abstract: Basically...

Quite interesting. If it would be possible to take a high-resolution look at the cochlea of people with T/HL, this would probably be a game changer. Finally, we could know what is *really* going on, instead of just guessing. However, seems like this method is not (yet?) up to the task: So...

Not really big news, as Auris already announced they would continue the phase 3 trial with an "amended protocol". Seems like that restart just happened. Auris Medical Resumes Enrollment in TACTT3 Phase 3 Trial of Keyzilen in Acute and Post-Acute Tinnitus

But don't you know that Big Pharma is not in control because all their T advances are destroyed by the mighty hearing aid industry? I read it on the internet, so it must be true! ;)

Didn't see that coming... This might be of interest for people taking part in the AM-101 (or similar) trial or having intratympanic steroid injections: Using anaesthetics doesn't help reduce the pain of the injection

https://www.boehringer-ingelheim.com/press-release/china-southeast-university-collaboration-develop-hearing-loss-treatments They started working with Kyoto University on this topic earlier this year...

I guess the study finished, at least there's a matching publication: https://www.ncbi.nlm.nih.gov/pubmed/27716604

Well, sometimes you stumble upon strange things. This is definitely one of 'em... ;) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4803736/ Basically they are currently trying to help people with cervical pain syndrome using cervical collars. A larger paper is in preparation. The article reports...

Just wanted to post this, too, but obviously it's old news. ;) Anyway, wanted to give this a boost as not all humble bundle customers might have seen this yet. Btw, you can choose to donate to "Action on Hearing Loss," too.

Action on Hearing loss funds research on stem cell delivery.

See their NEWS page entry from September 1st (unfortunately there's no direct link to the article, only to the news page). PRAGMA Therapeutics and UK Ministry of Defence’s Center for Defence Enterprise collaborate to support preclinical research on innovative treatment for tinnitus September...

Hmm, just stumbled over a previous study where they injected Gacyclidine (OTO-311) into the ear: Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. It's somewhat older (05/2010) and only a small number of people participated.