Recent content by benryu

Trobalt (retigabine) is a very different kind of dope :p Just to be clear Retigabine ≠AUT00063 by any mean, they happen to act in the same area but in radically different manners. Plus the retigabine is not meant for T. and its scope's too wide to be viable and it has numerous side effects. As...

Very unlikely, I can't think of any physiological reason for this to happen, there is no more reason for this than a reason for the drug to grow a penis on your forehead and transform you in a unicorn. haha (Worst case scenario would be it go back to how it was before because plasticity did...

Haha you got me :) :p

Many people would give anything for having at least a rat model for a cure for cancer, ALS, or HIV... If we are not positive, who can be ? The T. mechanism has been figured out, research will just brute force the lock until it opens, and I have no doubt it will be very soon.

In a nutshell I have a background in applied economics (lol), I drifted to applied maths and computer science, I was more specialised in behavioral models for virtual worlds but I happened to work a lot on neuroscience. ;) (edit: I was creating computer programs to mimic some regions of the...

Shit you got me !!! Well they should pay me for promoting their dope :p

Sorry to interfer here, but it has nothing to do with partial seizure... Most anti convulsant are sodium blockers, meaning that when you block sodium it gives potassium much more freedom of actions and impact. This is why some people get lidocain perfusions, it's a major sodium blocker and will...

Kv3.1 was heavily documented as the main channel for T. considering the number of papers confirming it, I doubt Kv7 is a winner. As I explained earlier Kv7 targeted by retigabine acts on interspike interval, meaning less T. spikes and it can possibly repolarize the action potential for some...

Yes, ototoxicity can be caused by noise, drugs or stress. EDIT: basically most of T. should be tackle (theorically) by AUT00063 providing it works as expected. The T. not directly curable by this (TMJ, tumor, edema as eg) are curable if the initial problem is fixed. (eg, if you can get a...

@Christian_B first it's a bit out of my area of expertise, I am quite confortable with the brain, but I did not work much on any other area of the body :p So from my perspective I don't recall any article showing that TMJ can cause excitotoxicity. (Anyone found something about this ?) It's...

@cdog I like you enthousiasm and motivation, but you don't know when to stop, do you lol? Seriously even with a lot of efforts I don't understand nor your point nor your question here. *__* Dude synapse are in 2 parts like talkie walkie emetor & receptor, if one if not working you just can't...

No I called the theories I read above "crazy" because they are as crazy as not suported by scientific evidence. Yes the mechanisms above were confirmed on human, and it has been documented for the last 20 years with numerous articles. ==> google is your friend. For the "idiots" comment, in case...

Wow, I have been in this thread for a few days and it's like war here. *__* I am really busy at the moment but I have seen so much misinformation around that it will be useful if I clear a few things out. You guys seem to trip on the area I did not explain much because of its complexity...

Hey guys, I am kind of off at the moment as I have a lot of work, I see a few discussion around topics that I already covered, maybe it can help to quote some info here! : The impact of retigabine on Kv3 is not necessary related to dosage but more a "physiological response" to the drug, like...