Recent content by brokensoul

Fully agree on that. Expected more discussion after I dropped the transcription on here.

Just look at the mess damage creates: Even the “healthy” hair cells are no longer properly aligned.

Isn’t the deal with Astellas for FX-322 alone?

I hear what you’re saying and both of you could be right, but at the moment I don’t want to draw any speculative conclusions beyond the actual facts. This might create high expectations amongst some people here who don’t look at the actual statement done by Chris Loose. Some people could be...

I cannot tell with absolute certainty from that text if the epithelial scarring would affect hair cell regeneration, but the text confirms my earlier statement that supporting cells move in place where the hair cell is lost. Looking at the images of noise induced damage for example does reveal...

Transcription: https://www.tinnitustalk.com/threads/frequency-therapeutics-—-hearing-loss-regeneration.18889/page-216 Audience: Besides the word score in phase 1/2, did you look at any other secondary end-points that would give you any indication of <inaudible>? Christopher Robert Loose (Chief...

In regards to epithelial scarring: Cochlear pathology, sensory cell death and regeneration https://academic.oup.com/bmb/article/63/1/25/377504 Contains a section on: Cell elimination and scar formation “... The term ‘scar’ is used to describe replacement of the original cell type (hair cell)...

@FGG should send her personal letter as she pleases. Entirely her effort and her decision. Tinnitus Hub and the community can send an additional separate and more formal letter. Though it’s probably best to wait for promising results in regards to tinnitus (e.g. after FX-322 phase 2a) as this...

Hi @Jorge P. Simoes, It is really great that researchers are reaching out to the biggest tinnitus patient community. Thank you so much for doing so. It is truly the right mindset to understand the need to engage with patients who actually have the condition. This is really positive. I very much...

As far as I know when a hair cell is removed from the epithelium, a supporting cell will move into that position to ensure structural integrity of the epithelium.

Completely different. People need to keep in mind that FX-322 only regenerates hair cells. So it can only resolve tinnitus for people whose tinnitus is the direct result of hair cell loss. If tinnitus is the result of cochlear synaptopathy you will need a solution like PIPE-505 or OTO-403...

I remember vaguely this has been discussed long ago, but I don’t know anything about this. What exactly leads to epithelial scarring? Why did @FGG and/or others not consider this a problem?

I don’t think lack of supporting cells is going to be a problem for the majority of us. I wouldn’t even disregard Audion’s solution because they don’t duplicate supporting cells. If Audion goes to market sooner they are certainly a worthy option to consider. I’m surprised to learn though that...

As far as I know it was never confirmed that his tinnitus and hyperacusis improved.

Do you have some good sources on this?