Recent content by Danad

It is also noteworthy that tinnitus can develop from just reduced auditory input such as with earwax, sound deprivation etc. with no injury from sound or toxins.

Seems difficult then to tease out the relative contribution of NMDA activation and OHC loss to tinnitus generation by salicylate.

Another study with no surprises linking hearing loss and tinnitus/hyperacusis. Review: Neural Mechanisms of Tinnitus and Hyperacusis in Acute Drug-Induced Ototoxicity

Heck, why not recruit all unilateral, high frequency tinnitus subjects to stack the deck.

Below is an estimation of the number of subjects in Phase 2a who will report tinnitus improvement: Total = 96 Non-placebo = 72 Estimated 70% have tinnitus = 50 Estimated 50% have unilateral tinnitus = 25 (only one ear injected, untreated ear still ringing) Estimate 50% require 2 or more...

Unfortunately, Will McLean's highly informative YouTube "Toward a Cure for Hearing Impairment" has been removed. Wished I had at least recorded the audio. Probably too many forward looking statements.

More evidence linking hearing loss, brain plasticity and tinnitus: Tinnitus-like “hallucinations” elicited by sensory deprivation in an entropy maximization recurrent neural network

Below is Dr Lustig's audio snippet from presentation around 1:16:30. He made no mention of hearing loss leading to tinnitus nor of hearing restoration's effects on said disorder. Sounds like he has felt powerless for so long to help countless patients with this that he's given up on it...

Firstly, let's talk about the stock, one of the few times in life that free $$ was staring you in the face. Having researched FX-322 to death I bought a ton following the IPO and I'm risk averse (still rather have no tinnitus than 8 figures though). Secondly, Dr Lustig's reply concerning...

I tend toward predicting a product launch late 2022 if endpoint results are met in the the three currently running trials with no adverse effects. That does put some faith in the FDA to do their job in a timely fashion and award Breakthrough Therapy designation. If tinnitus results are also...

Animal models apparently could not withstand multidosing (presume anatomical differences) but human subjects can. Good news if multiple injections yields proportionately better results.

Attached below is an MP3 of today's webcast (Q&A only since the initial part was just a review of company's online presentation). I learned that they were unable to multi-dose in their animal studies due to membrane vulnerabilities. The tone was rather zip-lipped though; as it should be given...

Here is a screenshot I took from the WSJ article a while back:

Quoting a Wall Street Journal article: “Fast track drugs often go to market after phase 2” I believe Frequency Therapeutics added the two additional studies to substantiate this. This is a huge unmet critical need.

With bilateral tinnitus cases comprising 39% and patients reporting poor localization at approximately 8%, TFI scores in the aggregate will not reflect the drug's full potential from treating only one ear. Characterization of Tinnitus in Different Age Groups: A Retrospective Review