Recent content by dbeats

This was before the disappointing results. From the newest report: “In light of the challenging financing environment, we intend to explore strategic options to advance and realize value from our pipeline including both OTO-413 and OTO-825, our gene therapy program for congenital hearing...

Disagree. There are at least 6 companies working on different hair cell programs right now: Frequency Therapeutics, Otonomy, Decibel Therapeutics, Akouos, Hough Ear Institute and a not disclosed partner working with Astellas. There are also many researchers in universities working on hearing...

The audiogram was not performed inaccurately. The audiogram is a highly inaccurate way of measuring hearing.

I wouldn't worry about it. Just give yourself some time to relax and things should go back to the way it was before you were exposed to these sounds.

You are fine. 50 dB is way too quiet to cause any damage.

You did it again! You throw out big claims with no data to back them up. I would love to take a look at the dozen pre-clinical studies that have completely diminished tinnitus in vivo animal models.

Please show me the data backing up these statements. There are things in the works, yes, but "curable"? "Preventable"? Big words you are throwing around here...

You're right, they removed it... Kudos to whoever archived the web page back in April. https://web.archive.org/web/20220426153740/https://innerear-disorders-therapeutics.com/

I was just referring to NIHL in general. They are definitely not running to the gun range afterwards, but I think the theory Chad presented is plausible.

It's all speculation. These are businesses trying to deliver a product into a market where there are no current therapeutic options. Stop acting entitled.

This is incorrect. Outer hair cells are extremely delicate, and NIHL is indeed caused by exposure to loud noises over time, but also from very loud short sounds such as gunshots. We're not talking tens of years, we're talking seconds, minutes, and hours depending on the sound pressure level.

If it's any consolation, steroids normally help restore some hearing with sudden hearing loss, and sometimes with noise-induced hearing loss. If some hair cells died after the acoustic trauma, they're not going to grow back by getting steroids.

Depending on how precise the measurement is, I'm guessing they could measure objective changes in tinnitus for potential treatments. A pretty amazing tool to be honest.

How is your audiogram? What frequencies does it show hearing loss and how much?

Look up cochlear organoids. It's being used to test these kinds of things.