Recent content by Diesel

CBS ran the report. Not Frequency Therapeutics.

Sounds like the hyperacusis I had for a long time. But I think the better term is "recruitment." Basically what's happening is you've got some damaged sound receptive cells in your cochlea, and they're sending signals incorrectly to your brain. For me, it was speakerphones, small electronic...

It may or may not need a Phase 3. Depends on if Phase 2b meets endpoints, and FDA says a Phase 3 is needed. By now, almost 300 patients have received FX-322. That's enough safety and adverse effect data for the FDA to decide if one is needed. Note: They're still on-track for a Breakthrough...

The FDA is specific on approving a drug to be sold in the US: 1. Favorable safety profile (low risk, or well-defined risks). 2. Specific target conditions the drug intends to treat. 3. Specific patient population that can see reliable benefits. IMO: Frequency Therapeutics has made the case to...

This honestly seems about right in terms of sale price. Consider what an asset pricing sheet for the patents / know-how would look like. They have zero projected return, since no market value was established. And, since the work is incomplete because they're selling mid-trial, more...

They received a grant from the DoD prior to the FX-322 Phase 1/2.

Today is my 4th anniversary of acquiring intrusive T and H. To those of you that are new and still struggling to cope... it gets easier.

It depends, but until a few million people have sampled the drug in their ears, one can only speculate. I suspect genetic conditions play a factor too. Me, my sister, brother, and father all started experiencing some level of tinnitus / hearing loss in our 30s. Stands to reason that 25-30 years...

It should be noted that the drug cannot provide a permanent gain, either. It has demonstrated that to some extent it is causing the regeneration of original hair cells or hair-like cells. The original cells we are born with aren't permanently durable, and neither will be the regenerated cells...

He wouldn't have been allowed into the trial (assuming Phase 1/2 based on the description in the video) unless he had demonstrated that his hearing loss was 'stable' at entry. So, his doctor would have had to show to the trial managers that he hasn't improved naturally or by any other means over...

I wonder if he was patient 937 from the Phase 1/2?

If the OTO-413 trial demonstrated more convincing positive outcomes, they would certainly not have gone down the same path. They would have options to continue to fund development that they don't have today. It's possible they would have considered an acquisition prior to a successful OTO-413...

It's unknown. So just saying "multiple doses didn't work" is misleading. And FREQ hasn't bothered investigating timing of the dosing, or any other alternative routes. They have discussed "multiple single doses" in the past, which might hint that the redosing happens significantly apart, where...