Recent content by joejunior

Looks like the questions have been filtered by either TT or Autifony

Has the question list gone to Autifony ? if not why? If so is the response available? If not when will it be available?

Take any medical report from the express with a pinch of salt.

Given the scale of the problem and the invisible suffering, a multi billion grant is in order to understand the issues, develop treatments and cures expeditiously.

I understand the European autifony trials are for tinnitus, do the findings then read across to the FDA? We are a patient lot waiting year on year for a snippet of positive news

I would be over the moon with a 50% reduction in tinnitus and hyperacusis say with no or little discernible side effects, that would be a real result. Just hope we get to that point sooner rather than later. Fingers crossed. To listen to music socially without stress and wincing, which is...

Exciting stuff - it appears Affichem might complete preclinical work in Sept so can move intoc clinical trials - anyoneone know it that sounds right?

I dont know where Autifony got the info that 18 month is the time period for shift of tinnitus from a peripheral issue a central one: The U.K.-based study began in October 2014, according to Dr. Domayne-Hayman, and seeks to improve tinnitus in patients who have experienced symptoms for at...

Does anyone have the Phase 1 results for AU0063, in particular the safety and side effect results, given the side effects of Regitbane another K channel modulator,

I dont want to startle reflex you: , but there is a lot of gaps to be filled here. The paper below is from 2014, I saw a couple of papers from this year http://www.hindawi.com/journals/np/2014/741452/ The ultimate benchmark for any animal model measuring subjective tinnitus is comparability...

:) I believe there has been some recent papers on the differences between rodents and human regading perception of tinnitus based on gap detection, just wanted to know a bit more about this and implications.

Ok so they have deisgned SF0034 by incorporating a fluorine substituent in the 3-position of the tri-aminophenyl ring of retigabine. This appears to make it more selective in that it only affect K2/K3 channels and not K4/5 and furthermore is more potent and less toxic, reducing the...

Crikey just had a look at the consortium members - this is a really powerful group http://www.otostem.org/partners/index.html

Thanks - the more the merrier

The space race increased competition between the Soviets and the US in their endeavours, which many say the Soviets won not least because of the MIR space station, although the US had the first man on the moon. All great achievements. I will reserve judgement. These projects were adequately...