Recent content by Justin Mills

My hyperacusis has worsened over the past few weeks. I’m experiencing distortion, and it’s painful when I talk or when others talk—it’s awful. Socializing has become really difficult because I have to endure the pain. The “s” sounds, in particular, are especially painful.

It’s not just tinnitus—this is actually related to hyperacusis. When you experience pain and/or distortion from sounds, it’s not just tinnitus but hyperacusis, often stemming from underlying physical damage like cochlear synaptopathy. When you hear the sound of your own voice, the synapses...

Yes, it's wonderful, and his other treatment has already worked on five children born deaf. However, it will likely take many years before it becomes clinically available.

Synapses are the most important to treat first because they are the most vulnerable. Before hair cells are damaged, it’s the synapses that are destroyed. Regenerating the synapses would restore all the sound information received by the hair cells, improving hearing clarity and the input of...

There is literally nothing else out there as a potential cure for tinnitus except Cilcare’s treatments. Frequency Therapeutics, Otonomy, and Pipeline Therapeutics have all failed. However, some of their approaches didn’t make much sense. For example, Pipeline specifically excluded people with...

"What we do is magical, to regrow auditory nerve fibers towards the hair cell"

I’m not sure how this compares to OTO-413 or the work by Frequency Therapeutics. Hopefully, Cilcare’s molecule will be the one that finally works, and with just one injection! How many years will this take?

So it looks like there are other places working on developing drugs to regenerate synapses, other than Otonomy and Pipeline Therapeutics. I guess it’s just a matter of time, although who knows how many years. Well @AxEars thinks it’ll be another 6. But I think it’s important to keep in mind...

Simple. You just regenerate the cochlea, the brain will then take care of rewiring itself. It's just like if you close your eyes and don't have light input, you'll see blue and red "noise." You restore vision input and the noise goes away. All that needs to be done is regenerating the cochlear...

The difference is synapses are more vulnerable and take the brunt of the damage. @OptimusPrimed is spot on, that is the primary underlying cause for tinnitus and hyperacusis. I fully believe that regenerating the cochlear synapses will be the most effective way possible to reverse tinnitus...

OTO-413 doesn't work by repairing hair cells. It works by regenerating cochlear synapses.

Looks like we're getting the news from everything, Pipeline Therapeutics, Otonomy, and Frequency Therapeutics in mid 2022.

Yes please do. Pipeline Therapeutics' drug and OTO-413 are our best two shots right now.

That's not right, no. Tinnitus is usually from damage to hearing, so having a drug that can regenerate the damage would treat the underlying cause of tinnitus AND would also improve hearing perception and clarity. It would also address such issues as hyperacusis that again are caused by the...

Yes but very rare, most of the people on this forum have tinnitus from loud sound exposure, which is most treatable by regenerative therapies such as Pipeline Therapeutics' drugs or OTO-413 that regenerate synapses. It probably would resolve tinnitus caused by ototoxic medication as well...