Recent content by paul mclean

If you're going to do Cerebrolysin, you should add in Vinpocetine, Pentoxifylline and Piracetam to it too. Here is a patent from Russia where they use all these compounds: Agent for sensorineural hearing loss treatment (versions)

Someone should tell Dr. Shim to look into intratympanic injections of 7,8-DHF. It restores IHC synapses and increases neurite outgrowth and is very cheap. I literally have some in my draw but no doctor in Australia would dare doing a DIY intratympanic injection lol.

I've been real busy recently but I've pivoted slightly in my approach. I have the Zoledronate ready to go but I've actually found a biotech company that can custom synthesise Risedronate-7,8,DHF conjugate for me which I can take in a pill/capsule form. I'd much rather take a pill that works...

It's actually very easy. AllDayChemist or IndiaMART. No prescription required.

It depends. If your tinnitus is from cochlear synaptopathy and the Bisphosphonates regenerate the IHC afferent synapses then it'll affect your tinnitus whether you have osteoporosis or not. Also my Zoledronic acid arrived today. The preparation begins, I'll need a period of 3-4 days off work so...

Will report back here soon, it has almost arrived at my place. I've read the study you're referring to . Here is another study using Bisphosphonates (Risedronate) and a TRKB agonist (7,8,DHF). They use Risedronate as a delivery method to get the TRKB agonist to the cochlear which increases NT3...

Yes you can. I am going to try Zoledronic acid soon. Going to do 0.5 mg IV infusion. i believe it'll work for my cochlear synaptopathy. Worth a shot. There is no need to use the full dose in my opinion (4 mg or 5 mg) as those are intended for osteoporosis. The reason why systemic administration...

I'll be doing 2 months of Oxytocin therapy soon. Will post results once I'm done with my experiences.

Fair enough. I actually ordered the Cerebrolysin for reason other than tinnitus (ADHD) but have seen others say it could help with tinnitus. I'll see what happens though.

I've been doing some research too and have found out that the compound Mannitol increases absorption of drugs through the blood-labyrinth barrier by a process called osmotic disruption. So that could definitely help with drug delivery to the cochlear. I've got some Cerebrolysin on the way...

Haha sadly you can only administer it via intramuscular injection which turns people off. It's reported to increase BDNF up to 300%. It also increases nerve growth factor. Sadly it's not guaranteed that any of this passes through the blood labyrinth barrier to enter the cochlea. It does help...

The best drug for increasing BDNF is Cerebroslyin. A Peptide noortropic used for healing traumatic brain Injury.

I've had multiple audiograms done and the specialist said they were fine with no damage at all. The thing is I struggle in almost every social situation with background noise. I can't understand people and everyone is mumbling, but when I'm at home lying in bed for example with no noise in the...

I actually have higher hopes for Otonomy's OTO-413 than Frequency Therapeutics' FX-322 to be honest. Otonomy are behind Frequency Therapeutics but there a numerous studies going on with BDNF and neurotrophin-3 growth factors repairing synapses in the cochlear. I have cochlear...

Please let that be true. If they are able to do the pivotal phase without redoing Phase 2, then that's a godsend and saves alot of time.