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Will you try FX-322 if and when it comes out? Also Ozzy Osborne has Parkinson’s now along with tinnitus. Tinnitus is not a toy. I wish it would be taken seriously. Peace.

Testing on humans within a year! I doubt it but still!

When do you think they will feel ready for the expanded access?

https://endpts.com/add-ear-gene-therapy-company-akouos-to-the-ever-growing-list-of-ipos-amid-covid-19/

https://www.bloomberg.com/news/audio/2020-02-19/baystate-business-politics-and-fish-radio Not sure if this was shared before. Breakthrough Status!!! Maybe...

https://theconferenceforum.org/wp-content/uploads/2020/05/CMO_360_newsletter.pdf

Wow if pathway Atoh1 uses up your support cells to make cells then frequency should be at least 35% i suspect at least a double response 70%. Since they are all about keeping your support cells.

25 dB loss at 3 kHz and 4 kHz, also high frequency loss of 30 dB at 16 kHz.

Her tone of voice was very hopeful. Also told her a lot of people are looking at this trial and hoping for the best.

Just called FX-322 trial center in Nebraska. They are accepting patients. They have lifted travel ban for patients traveling out of state due to COVID-19. I asked her if they will delay results. She said they are only a testing site. Frequency is the only one who knows this. I said these are...

https://seekingalpha.com/article/4351165-frequency-therapeutics-fxminus-322-top-line-data-from-exploratory-study-proves-promising More info about the conference, not just about the past top line data. This is the make or break point for the company!

She is taking her time because she wants this to work.

i know this was aleady posted from 2013. I would suspect it could take 8-10 years, until 2021 to 2023. She is super smart and this team is going to change the game. I have hope!

I feel you being worried... I am too. If this fails, we are going to have to wait a long time! The first phase is only about safety. In the second phase they will measure hearing improvements over 4 doses. They already saw hearing improvements after 90 days with one dose. They said the drug...

Have you had a full range hearing test?

Looks like once FX-322 is approved it will have to go through another trial to get approved by FDA to be used with (check 14:14) Otomagnetics :( Looks like Carl LeBel was on this team before Frequency. Check video at 5:21.

If I remember correctly, they did state tinnitus a few years back but for some reason they took it off the website.

Please explain how do they get FX-322 to repair hair cells in the right place where the damage is? Maybe I was thinking about this because the progenitor cells and support cells in those areas will be exposed. So they can turn them on. Thanks.

Wow! Three years time stage for FX-322 and this dang!!! Lot to bet on! I hope it all goes well!!! Just have to remember first Gen hearing repair won’t be perfect but just might be enough to help some of us get silence back.

Right things have changed now they are doing multiply doses so safety might be a concern here. More of a risk too! Wishing the best for everyone in the study and all the scientists They might not need a new formulation just a better delivery. If that is what you mean? I have very high...

Saw your post about headphones and hearing loss. Can I ask what your losses are and how high? Really sucks no one told me about this too! Either way dumb part is I knew something was way wrong but did nothing about It.

Gosh I really hope they get to phase 3. I would totally get in. Only thing is they better change the dB loss to go up to all frequencies. As of right now I just barely miss the dB loss need to have at least 26dB up to 8000 Hz. So I would not make it in right now. Just to think two years from now...

This is why I believe Frequency will make a huge impact. David CEO, Jeff, Bob, and Will etc. The company has all the right people to make it work. Anyone buying any stock?

Sorry, late to the party. They can get hair cells to regrow but can they get the neurons to reconnect to the brain? I don't want to be greedy if they can give just 10-15 dB back that would be awesome.

Hi IvanRus yeah 3-4 hz left ear 25db and right ear 3hz 25 db lound music and earbuds then tested me above 8kHz I can remember bud had 30 db loss at 16000 hz due to ear infection my audiologist said most likely the T was due to that. Since she told me that she has seen people with the noise...

Thank you sir for this! It lovely and amazing! I know I should not be down and out my hearing loss is only down to 25db at a couple places. I know o need to carry on but dealing with aftermath of not dealing with my hearing issue sooner. Hateing myself for it. Also dealing with death of LP front...

Noise and anything that causes sudden hearing loss.

Yeah it is amazing went to tinnitus clinic told them about hearing restore they said only in mice don't hold your breath. Talked to an audiologist they had no idea about these companies. They work for hearing aid companies. As long as we have breath we have a chance everyday is a battle!

My guess is the first treatments won't be perfect and won't work for everyone! 5-10 years us hard of hearing will have options more then hearing aids!

Hey Jake how is your T going?

David in this video talks about the progenitor cells being in he right place. That should put to rest people who wondering if the cells end up in the right place!

http://www.xconomy.com/boston/2017/04/11/frequency-nabs-32m-will-push-hearing-loss-drugs-to-human-studies/ They will have to figure it out!! They got 32 million dollars!

http://cureconnect.org/wp-content/uploads/2016/11/VP-Mol_Cell_Bio_10_23.pdf They were looking for help!!! 5 years!

In an article they said in young animals they got great data! In mature animals not so much I hope the figure out why that is and fix it! Please help us!!!

Correct but it is proof of concept! I agree once we have proof it works then stop with the animals maybe use on people on death row!

The problem is it is government funded if it was private then it go much faster! They want to start phase II. We shall see!!!

It is so weird met a guy was drummer has hearing loss NIHL says can't hear tinnitus and NO H!!! WTF he has more damage then me and my T sucks!!! Thank god for no H!!! Truely sucks but as they say "help is on the way!"

http://adisinsight.springer.com/drugs/800048613 Orphan drug status NO! I would like to thank all the people doing phase I for safety! You are really helping a lot of people by doing this! Thank you thank you!

Granted this works! When would most people want to try this? My choice is phase III....if it works.

Yeah I spoke with her asked her about the trial she said still waiting for funding. Call back in a couple of months. Not much more to add sorry :(

Amazing in another 4 year where will we be. At a better place then now. Thanks you for this!

Thank you for your inquiry regarding Otonomy’s clinical trials for our tinnitus product candidate, OTO-311. The FDA has cleared the company's Investigational New Drug application (IND) for OTO-311. The IND clearance enables Otonomy to initiate a Phase 1 dose escalation clinical safety trial of...

I am only saying that because they doing a lot they want to help people with genetic conditions also protect the ears. They have a lot on the table. A guy on forum was saying 3 years for a growth factor like shimbo from South Korea I can only hope 3 years!

Yes they are! If FX does not work I would expect a cure to come from Decibel maybe 10-20 years who knows.

Year from now do you think if trail starts will you try anyway. You might be able to bring some of your hearing back maybe not all. Worth a shot!!!!

Why do think 90 percent is gone? How much loss do you have? Is it severe loss? Do you qualify for CI?

Hope is never lost!!! Look at Superman Mr. Reeve!!!!

This will happen but it should not! Where is the proof of concept? Animal data? Sure they did on a couple of animals but they died a couple of hours later! Huminaity is not ready for this science is not ready for this. As far as I know it will take place in China they are only country that let...

I would take that shot better then what we have now!!!!

How's your tinnitus? How are you managing?

https://www.laboratoryequipment.com/article/2017/05/humans-have-questions-nature-has-answers Talks about FxT... not sure if this has been posted I like the approach!

It could help with tinnitus. Could help......

Good questions my guess is the higher frequency hearing loss is better since easy for med to reach. I am sure they are thinking of everything. Keeping my fingers crossed!

http://www.the-scientist.com/?articles.amp/articleNo/49482/title/New-FDA-Pathway-to-Accelerate-Development-of-Cell-Therapies/ Not sure where to post this. Not sure if this means for ear stuff but either way very good news!

I have emailed Decibel, their response: Thank you for reaching out and I apologize for not getting back to you sooner (I was out of the office all last week). I wouldn't say we are in stealth mode--we published our data, do press releases, etc.--but you are right that I can't say much about...

We appreciate your interest in this compound and for your message. We have not begun human testing for the compound yet. We are not able to provide any forecast about when or if we will test this for tinnitus sufferers. We have a corporate policy that precludes us from sharing such information...

Every War film documentary that I have ever seen never has never talked about tinnitus. From solders, civilians, and kids no one talks about hearing loss. I wonder how many people have tinnitus and hearing loss from Boston attack? It is an invisible so no one talks about it. I think of Wars...