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Looks like the questions have been filtered by either TT or Autifony

Has the question list gone to Autifony ? if not why? If so is the response available? If not when will it be available?

Take any medical report from the express with a pinch of salt.

Given the scale of the problem and the invisible suffering, a multi billion grant is in order to understand the issues, develop treatments and cures expeditiously.

I understand the European autifony trials are for tinnitus, do the findings then read across to the FDA? We are a patient lot waiting year on year for a snippet of positive news

I would be over the moon with a 50% reduction in tinnitus and hyperacusis say with no or little discernible side effects, that would be a real result. Just hope we get to that point sooner rather than later. Fingers crossed. To listen to music socially without stress and wincing, which is...

Exciting stuff - it appears Affichem might complete preclinical work in Sept so can move intoc clinical trials - anyoneone know it that sounds right?

I dont know where Autifony got the info that 18 month is the time period for shift of tinnitus from a peripheral issue a central one: The U.K.-based study began in October 2014, according to Dr. Domayne-Hayman, and seeks to improve tinnitus in patients who have experienced symptoms for at...

Does anyone have the Phase 1 results for AU0063, in particular the safety and side effect results, given the side effects of Regitbane another K channel modulator,

I dont want to startle reflex you: , but there is a lot of gaps to be filled here. The paper below is from 2014, I saw a couple of papers from this year http://www.hindawi.com/journals/np/2014/741452/ The ultimate benchmark for any animal model measuring subjective tinnitus is comparability...

:) I believe there has been some recent papers on the differences between rodents and human regading perception of tinnitus based on gap detection, just wanted to know a bit more about this and implications.

Ok so they have deisgned SF0034 by incorporating a fluorine substituent in the 3-position of the tri-aminophenyl ring of retigabine. This appears to make it more selective in that it only affect K2/K3 channels and not K4/5 and furthermore is more potent and less toxic, reducing the...

Crikey just had a look at the consortium members - this is a really powerful group http://www.otostem.org/partners/index.html

Thanks - the more the merrier

The space race increased competition between the Soviets and the US in their endeavours, which many say the Soviets won not least because of the MIR space station, although the US had the first man on the moon. All great achievements. I will reserve judgement. These projects were adequately...

Not directly related to tinnitus I think but progress nonetheleless http://medicalxpress.com/news/2015-05-experts-surgical-approaches-auditory-brainstem.html

Overall it looks like there are some good papers and research being discussed at this conference, it's certainly an improvement from the earlier TRI conferences.

This is easy to read article about K channels and relevance to tinnitus: http://www.medicalnewstoday.com/articles/245357.php

Good to see Autifony is getting increased funding. I am very keen on the objective measure being developed with AOHL Newcatle Uni etc, athough that is not a prerequisite for the trials. The objective measure will be universally beneficial once developed. A few questions: When au0063 was...

I beg to differ, one of the chief architects of TRT, maintained that TRT cured tinnitus, and of course this claim was taken up by the TRT lobby. Of course they are more modest in their claims now. Then the TRT people used to say there is no need for a cure. Of course they might say now they...

it will make better trials if it is successful, if they can objectively measure the tinnitus, then that become an e;igibility criteria for a trial, and during the trial an objective measure can assess progress or not

This demonstrates that Autifony and Action on Hearing loss, are working on having an objective measure for tinnitus. This is good news, whether its achieved before or after the drug trials. This will not affect the trial timing but would have a huge impact on the quality of the data analysis -...

Anyone aware of this spin off project from Autifony. Seems like Autifony want an objective measure: http://www.ncl.ac.uk/press.office/press.release/item/funding-from-charity-for-new-treatments-to-silence-tinnitus

Does anyone know the milestones ? When is Autifony Phase 2 for tinnitus complete and more importantly when will results be reported?

These guys have been waffling on about VNS for years, I know they have gained a lot of funding for their research - I haven't seen any objective evidence of it working or having potential. We need smart oversight so that the little funding that is available for tinnitus research is well directed

I see TRI has on its main page a link to TRIH, which is NOT an initiative of TRI. TRIH which is Translational Reserch Initiative for Hearing is entirely an initiative of Action on Hearing Loss, in fact its one of the best programs for research globally...

From Portugal: http://dev.biologists.org/content/142/11/1948

Here is more: http://medicalxpress.com/news/2015-05-inner-ear-hair-cells-advances-deafness.html#inlRlv This is very encouraging, not only have they created the 'parts list' but it is publicly available. One of the issues in private medical research is lack of sharing of data, and patenting of...

Interesting graphic but your conclusion may not be correct. Take a simple example - the light is on in your room. You conclude I can;t reduce the light - the whole room is lit up. When all it takes is flicking a switch.

AOHL stand for Action on Hearing Loss, a pre-eminent charity for hearing disorders and tinnitus based in the UK. THey have carried out ground breaking work, for example the work of Dr Rivolta, has been world class and his discoveries have been groundbraking, they support basic research...

Good article based on a paper published in 2011. means the work may have been carried out 2005 - 2009? This is too slow and demonstrates that the whole process needs to be streamlined and sped up. As I have said before hearing research and hearing conditions are neglected in terms of govt...

The main cause of tinnitus is acoutic trauma. The main roadblock to effective treatments is lack of govt funding ie they dont care about the human suffering or the economic impact of hearing disorders ( hundreds of billions of $). The knock on effect of this is inadequate funding for research...

been hearing this for years , the timescale has dropped from 5 to 10 or 10-20 years to within 5 years. I have seen progress but there has been no success story so far, However there is a lot more going on, some of it high quality research some of it very suspect. Instead of speculating where...

Here is a bit from the patent on tinnitus Hearing loss represents an epidemic that affects approximately 16% of the population in Europe and the US (Goldman and Holme, 2010, Drug Discovery Today 15, 253-255), with a prevalence estimated at 250 million people worldwide (B. Shield, 2006...

Cant see cost being an issue if it proves successful. Cost will come down and the speed of the therapy will improve. Thats a given. On the NHS for example the treatment will be available to all at no cost to the patient. If it turns out to be a one off procedure with maybe a couple of follow up...

Suggest this is filed under 'Alternative Treatment and Research.'

I dont know what feedback participants need to give, but it may be and A-B-A test A = baseline ie no autifony B = with autifony ie test the baseline ie no drug then the drug, then back to baseline again. A-B-A test is often an improved way of testing compared to A-B . Particitipants may be...

The RTNE hospital on Grays Inn Rd should be at the very least looking at the HIFU machine at the Royal Marsden and ideally conducting some trials. Both are NHS teaching hospitals so are in the same organization. I will write to them to inform them and ask what they are doing. Anyone else can...

If it works it will be fast tracked.

Here is what HIFU procedure looks like, at best it is very precise surgery, without the surgeon and the risks of surgery, http://geneticliteracyproject.org/2015/04/invasive-surgeries-may-be-replaced-with-ultrasound-therapy/

This all seems a bit flakey to me. How much have they got in govt grants etc over the years?

Looks like the NHS are looking at this for cancer in the UK, and also that Ablatherm ( the French co that makes HIFU) is seeking de novo rather than FDA approval ( which is faster in the US) . http://www.itv.com/news/2015-01-21/ultrasound-a-new-frontier-in-cancer-treatment/ We need expeditious...

Your head will be in a fixed position during the procedure which is short. The ablate precisely the spot of interest, the accuracy is high, HIFU has been used successfully for some neurological conditions. The key question now is when it will be developed and rolled out for tinnitus, for...

Of course it would be a 3D scan pinpointing the exact location to be ablated, the location is fixed by the MRI. THe focussed ultrasound targets the location and ablates the cells.

The reasons its so expensive at present are many eg it may be offered by private clinics only at present so there is a profit motive which would not be the case if it was on the NHS for example where they will bring down the cost to govt, at no cost to the patient. - I suspect there are more...

THe key problem is that the r&d is not seamless and not being expedited, this is adding decades to the search for a cure.To find a cure sooner we need: - seamless research - increased and targeted funding - faster throughput of research The alternative is piecemeal research, lack of funding...

There is no cure at the brain 2 clinic as far as I can see, There is jiggery pokery magnetic stimatulion that may or may not give some releif for the duration you are in the clinic - thats about it. HIFU has had success in term of resolving a number of neurological condition - they need to...

Another scam - dont buy it

Interesting, now when will the results of this study be picked up and investigated further. It should be immediate and seamless, if govts ( who are employed by us) cared about audiitory conditions rather than paying lip service.

I am disappointed to see that TT has effectively a shop front for TRT. This idea that there are only a few witchdoctors around the world who can do TRT properly is a convenient excuse for when TRT doesnt work. TRT is simply a sham.

Its a good working assumption that Autifony drug will not work. If it does work its a bonus. Endless speculation as to who what why mechanisms , there is no one here who appears to have beyond a superficial knowledge and forgive me for saying this but most are simply ignorant when it comes to...

The Cochrane report has has already comprehensively demolished the arguments in support of TRT.

The typical response to 'when will there be a cure' for hearing loss and tinnitus is always in 10 years. Indeed one of the lead researchers at Stanford was even more optimistic in the early days of stem cell research. Now this is being modified to '5 years to clinical trials' whereas we are at...

That paper is a rag - dont believe it. Headline says 'drug to end tinnitus hell' then rehashes what is essentialy old news about the trial. There are quite a few papers in the Uk to be avoided if you want real news

I have mainly been involved in highlighting research and new developments and also exposing dodgy treatments. However I see advocacy as being the key requirement, as this drives everything else, and is a major shortfall. And this is were the strength of numbers can help. having spoken to...

true, its a start, it may lead to something, maybe something unexpected.

Clearly more govt funding is needed to expedite the research. A massive increase is required.

This seems a crude, inelegant heath robinson type treatment

Part of AoHL research is TRIH Translational Research Initiative for Hearing (nothing to do with TRI). Here is their latest newsletter: https://www.actiononhearingloss.org.uk/finding-cures/translational-research-initiative-for-hearing/consultancy/trih-newsletter/

I can appreciate how this might work, at sound ow amplitudes the eardrum would behave as normal , for higher amplitudes it would be stiffer, trick would be to get the frequency response function matched to requirements, at a range of amplitudes. As a stop gap measure it might be useful but will...