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  1. Auricle

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    As I understand it, dysacusis (which, in my case, presents as saturation and distortion of high frequencies in the left ear) is a neurological symptom. It may result from damage to the spiral ganglion neurons, specifically the dendrites that connect to the inner hair cells (IHCs), which are...
  2. Auricle

    Inner Ear Hair Cell Regeneration — Maybe We Can Know More

    Thanks for the link. Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear mentions the same 3 transcription factors, Atoh1, Gfi1, and Pou4f3, but goes into more detail than the study pointed to by @pants. That study mentions regeneration but most likely means supporting cells...
  3. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    According to this literature review paper from 2013, it's possible using endoscopy but not easy: Drug delivery to the ear
  4. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    The figure at the front of the publication shows two purple arrows, one trans-tympanic and one from the direction of the Eustachian tube. It's gotta come from somewhere...
  5. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    Details are in: Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries
  6. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    The first method takes a long time, but according to the authors, cochlear pumping is much faster. From the linked publication: "Cochlear pumping distributes drugs evenly along the entire cochlea within minutes"
  7. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    In a nutshell (from the pre-print at the posted link): "low-frequency air pressure oscillations applied to the ear canal at 4 Hz, which caused large amplitude (~ 80 µm peak-to-peak) stapes displacement" Unlike the other paper I posted a link to, the CP one is pretty readable.
  8. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    This looks similar to what you are suggesting: Steady streaming as a method for drug delivery to the inner ear There's also cochlear pumping, which looks more promising to me in the mechanical category: Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries