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Well, they should restart the process. There is no need for more double blind placebo studies. Take ten random patients. If it works on the first, the second, and so on—curing all ten out of ten, or at least not harming any of them while curing 50 percent—I am sure their stock price would rise...

This sounds reeeeally big, maybe even a breakthrough? Years ago, I read a scientific article describing how inner and outer hair cells resemble a microscopic wheat field. However, they could not be viewed in vivo because the cochlea is one of the hardest bones in the body, and its proximity to...

The tinnitus I have is more of a ringing, and I would say it’s on the left side—either in my ear or maybe my brain. It’s constant 24/7 but reactive to loud noise, certain herbs like basil, rosemary, and oregano (due to their salicylates), as well as colds, the flu, or headaches. These all spike...

Hey, Big Spender! No, just kidding. It seems this paper has caused a lot of excitement. A reason to celebrate? Well, I hope so, but don’t bet the farm on it. I am inclined to look at it—how would I explain it? Maybe the way an American looks at the US national soccer team. They are not very...

Speaking as someone who habituated to tinnitus back in the 90s through TRT but never fully adapted to noise sensitivity or hyperacusis and then later experienced a return of tinnitus, I find the work of the Bionics Institute intriguing. For example: a) If they measure the tinnitus volume of a...

@Mathilda, mulling over your story and comparing it to the days when I was bouncing from doctor to therapist, some things you said brought back memories. You mentioned a 20% reduction in tinnitus—I’m happy to hear that, and I hope it lasts. About 25 years ago, I did a therapy program at a...

The modern world is becoming louder rather than quieter, increasing the risk of further hearing damage. Whether due to acoustic trauma, aging, a flu virus, or a pharmaceutical side effect, the chances of experiencing hearing issues grow with each passing year. If there were a drug that could...

My sympathy. The brand of vaccine might have played a role, the company that manufactured that particular vaccine. In situations like this, where a new virus emerges and multiple vaccines become available, it is often only afterward that we learn which one may have had unintended effects.

This could be very important. Now, all we need to do is go back and test those failed pharmaceutical and biopharmaceutical candidates using this new delivery method. All you tinnitus punters out there, get yourselves on the list for the upcoming trials! I am volunteering for the placebo group...

Well, the Donald is older now than Joe Biden was when he started. If CNN is anything to go by, Elon Musk’s push to downsize the federal government is leading to all sorts of blunders—like firing the people in charge of nuclear defense, the ones overseeing bird flu control, or those responsible...

Is Ebselen the new Viagra? Just kidding, but it would certainly spark competition among other biopharma companies. A combination of a drug that helps with a tinnitus spike and another that repairs synapses, hair cells, stereocilia, or whatever (say after a new noise exposure) would be on every...

If you end up in an emergency room with severe COVID-19, surrounded by a surgical team trying to keep your lungs open (God forbid), they will be completely focused on keeping you alive and breathing. They are not going to ask whether you have a history of auditory problems. They are on the front...

https://en.wikipedia.org/wiki/Eleanor_Maguire The brain scientist linked above conducted a comparative study on the brains of London taxi drivers and other groups, such as bus drivers. The study revealed that taxi drivers, who had to memorize not only street names and locations but also how...

That really is something the guys and gals in white coats need to figure out. I recall one research group mentioning that their drug had difficulty accessing the lower frequencies of the cochlea. Kind of fundamental, don’t you think? It’s like saying, "We have the wonder drug, but we can’t...

It certainly raises questions. For instance, in my case, I’ve had a squint since childhood. The operation to fix it wasn’t 100% successful — it’s mostly cosmetic — but I wrestle with face blindness (prosopagnosia). Until now, I had more or less assumed that noise damage caused my tinnitus, or...

Tinnitus since December 2023? Hang in there. There’s a good chance you’re over the worst of it by now.

@Frédéric, I have to say that I am bowled over by your depth of scholarship. To be able to plow through all these scientific papers and understand them, especially when English is not your native language, is amazing. Hazel, Marcu! Put that man on the payroll or give him a promotion. In trying...

Human brain samples contain an entire spoon’s worth of nanoplastics, study says I had originally intended to post this under the heading of humor (brain plasticity, habituation, and all that). It’s something for everyone to be aware of and to keep up with as times change and new research...

Is tinnitus research still in the poorhouse? I heard that Trump wants to cut medical research as well, though what he says tends to be volatile and temporary.

It seems that hearing research and tinnitus research are developing on a wide front, to borrow a phrase from military technology. The Bionics Institute focuses on finding an objective way to detect and measure the volume of tinnitus, which could accelerate the pace of research and clinical...

So, the damage is (or is likely to be) in the hearing nerve rather than the cochlear hair cells? All we need now is a kindhearted multibillionaire, preferably someone suffering from tinnitus, hearing loss, or a similar condition. News like this, people thinking outside the box, cheers me up a bit.

I might go even further than that. I recall one of the doctors saying years ago that once you develop tinnitus, it is some sort of “lesion” that is not well understood. Once you have it, you become more sensitive to further hearing damage. That suggests living in a quiet part of the country...

My sympathies for what you are going through. I don't have a medical or audiological background, other than having experienced the same challenges you're facing. Please take the following suggestions with caution, or feel free to disregard them entirely: a) Avoid loud noise as much as...

Boy, are we in for an entertaining time! What else would you expect? Hollywood has burned down, and the entertainment capital of America (and much of the world) has shifted to Washington, DC.

It’s great to have some clarity about the background of the Frequency Attempt. Scientists sometimes get excited, and that’s completely understandable—it’s probably one of the things that makes their profession so engaging. Now that I think about it, earlier this year, I posted a link to New...

@lymebite, are you referring to FX-322, FX-345, or both? If what you say is true, then they should not discard the data. Someone in the future might discover the equation, delivery method, or "magic potion" needed to make it work in vivo. But sinking another billion into this? Jay, I am not...

I have been mulling over the stories that emerged during Trump's first term. Chaotic would probably be the word most commonly used in the reports. The British ambassador—or was it the consul?—faced a lot of criticism after his report to the British government got leaked to the press. Let's just...

You’re fired! (Apologies to @Anomalous for hijacking their picture link.)

There is quite a variety of therapies and machines currently being tested, including electrostimulation, electronic implants, and sound therapies. I believe it will be a significant milestone for bionics if their technology becomes the standard for comparing, contrasting, and evaluating these...

Sorry to hear that your situation is so difficult. I hope you can find an ENT who can help, or perhaps some fellow sufferers can recommend a good one near you. From your avatar, I see you joined in December 2024, so I presume your tinnitus began around that time. That was only about a month...

Relax. Most people improve or adapt within the first year or so. That does not necessarily mean your tinnitus will go away completely.

I have been experiencing a tinnitus spike for a while now, but that is another story. Yesterday, while at the supermarket, I was looking for some Magnesium. It is supposed to be good for you, right? However, after reading through some threads, it seems there are various types of Magnesium that...

Accomplish number [4] above, and everything else will fall into place.

Hearing about ongoing research gives me a sense of optimism. If researchers have already managed to reduce the volume for patients with cochlear implants, perhaps they’re now working on developing a milder, less invasive, and more affordable implant to achieve similar results.

In my mind’s eye, I can picture a future ENT, someone completely reliant on spreadsheets and printouts, sending a poor patient back to work in a noisy environment that only worsens their hearing. But hey, that’s the system for you. Your best friend in such a situation will be the amount of...

Why, I’ve been 21 for the past fifty years—plenty of salt on the porridge does the trick! Of course, there’s always a danger of some therapy being left to gather dust on a shelf in the archives. However, with an active group like Tinnitus Talk, it’s far less likely than it was in the days...

The same might apply to me, but it’s a great comfort knowing that she dedicated her working life and expertise to the tinnitus cause.

You’re probably better informed than I am, but during a recent conversation with an audiologist—if I understood him correctly—difficulty understanding voices in noisy environments is often due to high-frequency hearing loss. That said, I wouldn’t bet the farm on his explanation, as tinnitus...

Something echoes in my mind about an article Dr. Nagler wrote — I’m talking about way back, ten or even twenty years ago. The volume of a person’s tinnitus doesn’t seem to be closely related to the level of irritation or intrusion it causes. My interpretation is this: you can have two people...

I don't think I'll be waiting around on Planet Earth that long, no matter how promising the research seems. But life goes on—people come and people go. We need to stay vigilant about how and where the funding is allocated, should it come our way. I have no doubt that the management teams of...

Now that the dust is beginning to settle, we have to ask ourselves: “What was that all about?” The main scientist—I can’t recall his name, but it’s mentioned somewhere in the FX-322 thread—seemed to have strong belief in his remedy involving small molecules. Molecules of what, I wonder? What...

My sympathies to you and everyone else who suffers from tinnitus and believed they were furthering the cause by contributing their savings. As a retiree, I found myself unable to afford investing in a foreign company since I rely on the old-age pension. Just speculating here, but I would...

I tried it during the early stages of my onset, probably in the second or third month. It didn’t help me, but I met other sufferers in the “submarine.” One person said it helped him, while another had a similar experience to mine — no noticeable effect.

OU Neurosurgery? Is that Ontario University Neurosurgery? Oregon United Neurosurgery? Or maybe Oogadoojoo Neurosurgery? I’m delighted to hear that you’ve found an escape route for yourself. Meanwhile, we poor sufferers have to wait for the statistics and success rates before we can “all pile in!”

Taking a historical perspective on what you mentioned, Howard Hughes, the man they based the movie The Aviator on, suffered from tinnitus among other issues in the last century. He actually established a research facility dedicated to hearing and tinnitus. Unfortunately, as we know, the...

Now, that's a big question. It depends on the jurisdiction where you take your case. If I lose, I might end up liable for the other party's costs. Some counterarguments that might be raised include: "Prove that the sound of the alarm was the direct cause of your (increase in) tinnitus."...

Another Sad Story: Two weeks ago, I was doing my shopping at a large international grocery chain, not a small mom-and-pop store or a five-and-dime shop. I picked up my groceries and went to the self-checkout till to scan my items and pay. There was a supervisor nearby, keeping an eye on...

Oh dear!

I realize you were trying to introduce some humor. However, with some of the folks on here, just the odd one, mind you, I hope they do not take it the wrong way or do anything rash. We need every tinnitus researcher to have a long and productive career.

What you say has a grain of truth. Progress, growth, change, decay, or even learning a subject or a language can occur gradually and incrementally. However, it often happens in spurts as well. This medication is not the first one to lower tinnitus. We have Lidocaine (which can only be used...

How do I begin, @RadioKid722? First, let me say it is wonderful that you have found God. I might challenge your faith somewhat with the following story. I once met a soldier in Europe who was a member of a tinnitus group. He vividly recalled the day his tinnitus began. His platoon was engaged...

Duh... Please correct me if I am wrong here. I would love to be proven wrong, but Menière’s (pardon my French) has to do with the organ of balance, which is located right next to the cochlea. That said, I might still benefit from the success of the trial, as my sense of balance is not the...

If I recall correctly, back in the 2000s, some scientists conducted experiments on guinea pigs that were somewhat cruel. First, they conditioned the guinea pigs to feel anxious in an atmosphere of silence, likely through the use of electric shocks. When a sound or noise was present, no shocks...

In my humble opinion (which I acknowledge may not count for much), the rise in Bitcoin might reflect a rise in fear. It seems that money has to go somewhere, and in today's world, uncertainty is everywhere. France and Germany are struggling with new elections. Russia and China each face their...

Oh oh! Is this a warning sign? I am still enthusiastically praising this new method before it is even widely available. Back in the early days of my tinnitus onset, debates raged over whether patients should or should not drink alcohol or coffee. The argument was settled more or less; they...

It would take time to develop the technique. The patient would receive a general anesthetic and be securely restrained. The high-precision surgery would then take place, performed either by a surgeon, a computer-controlled keyhole surgery system, or a combination of both. If it’s not feasible...

A British commentator on the radio suggested that Ukraine’s strategy might be aimed at gaining a stronger bargaining position once the war ends. The idea is that it all comes down to negotiations. For example, after a ceasefire, Zelensky might propose something like, “We’ll return Kursk if you...

I found a book in a secondhand shop a while back about securing funding for research in the UK scientific environment. I still have it, though it’s quite dog-eared now. One of the first rules in the book was: “Don’t work in isolation; network as much as you can.” Interestingly, this reminded...

You’re diving into a deep and complex topic—perhaps a bit removed from the focus on presidential elections. When I was younger and less thoughtful (though still foolish), I used to be mildly critical of the United States and the challenges faced by African Americans. But over time, I’ve come to...

Government restrictions on research can certainly be a barrier in Europe. However, in the States, they often circumvent such restrictions by conducting experiments in third-world countries. While this approach might not be entirely ethical, it’s not necessarily illegal. Companies could justify...