Frequency Therapeutics — FX-345

We believed in Frequency Therapeutics when, in reality, they were nothing but miserable scammers. What we are suffering now should have affected them instead.
Now that the dust is beginning to settle, we have to ask ourselves: "What was that all about?"

The main scientist—I can't recall his name, but it's mentioned somewhere in the FX-322 thread—seemed to have strong belief in his remedy involving small molecules.
Molecules of what, I wonder?

What made him think they could regrow inner or outer hair cells? Did he test it on lab animals? Did it alleviate or cure their tinnitus? Improve their hearing? Help with hyperacusis? Was any testing done using discarded cochleas from cochlear implant surgeries?

At one point, they appeared to have trouble with delivery, if I recall correctly. Something about the drug not reaching the frequencies at 8,000 Hz and below. One thing that sticks in my mind is that no mention was made of the synapse or stereocilia.

I'll need to check all this again to see if I misunderstood something.

After all the hullabaloo, it would be nice to think we've learned something new from it all, however simple that might be.

As it stands, though, the only thing we seem to have learned is about stock option payments and the finance market. :(
We need to let it go. Unfortunately, those who questioned the initial results and choice of outcome measures as "fishy" were shouted down. In the future, we need to ensure that people can freely challenge such claims and point out potential issues to those who may be overly trusting.

Any company that uses speech-in-noise tests or relies on mainstream media to hype their research is a big red flag.
I don't disagree with you—we do need to be more cautious.

Still, I can imagine that in a decade or so, a new wave of tinnitus sufferers might end up losing their money all over again. It's an ongoing question.

The principle itself—a private company collecting money from sufferers to fund research in hopes of finding a cure or alleviating tinnitus—isn't inherently bad or dishonest. After all, tinnitus and hearing damage seem to be the orphans of government research.

That said, it's crucial to keep a close eye on how much the company's staff are paid, whether they have clear and achievable goals, and what the research timeline looks like. However, funding might be better handled through straightforward cash grants rather than selling company shares.

There are some incredibly wealthy individuals who suffer from tinnitus. If they got organized, we might actually make significant progress.
 
can imagine that in a decade or so, a new wave of tinnitus sufferers might end up losing their money all over again. It's an ongoing question.
@Joeseph Stope, I imagine that by then there will be several effective tinnitus treatments available. Additionally, we might finally see some semi-effective hearing solutions.
 
@Joeseph Stope, I imagine that by then there will be several effective tinnitus treatments available. Additionally, we might finally see some semi-effective hearing solutions.
More and more research and the beginnings of clinical studies are emerging every week and month. Cilcare shows promise, as does Rinri Therapeutics. Mass Eye and Ear made impressive advancements this year. Here's to a hopeful 2025!
 
I imagine that by then there will be several effective tinnitus treatments available. Additionally, we might finally see some semi-effective hearing solutions.
Lol, I doubt it. More like a minimum of 50 years.
 
Lol, I doubt it. More like a minimum of 50 years.
I don't think I'll be waiting around on Planet Earth that long, no matter how promising the research seems. But life goes on—people come and people go.

We need to stay vigilant about how and where the funding is allocated, should it come our way. I have no doubt that the management teams of these research groups genuinely believe they are onto something. A bit of belief can go a long way.

However, the failure of Frequency Therapeutics left many people disheartened and out of pocket. They have my sympathy.
 
Let's start fresh with a new class action. Given the medical impact, I believe we can build a strong case together. Many similar cases, even involving other securities scams, have been successful in progressing their class actions. For example, take a look at the Lightning eMotors class action case for reference.
 
Something to consider: if companies fear being sued for any reason, they may have less incentive to continue research. At the same time, taking money based on false promises should be punished. It's definitely a catch-22.
 
Yeah, that sucks for those of you who got duped. But spending thousands more just to find out—after possibly fighting a lengthy legal battle—that the LLC has no assets to secure a judgment from?

That's bordering on insanity, unless you've got monopoly money to spare.
 
We would be suing David Lucchino directly, not the LLC. Even then, since the LLC merged with Korro Bio, it is possible that Korro could also be held liable. However, in reality, Lucchino should be the one held responsible for his misleading statements, not the LLC.

So far, neither case has progressed because only two people have filed lawsuits against him. We need more participants, which is why it is called a Class Action.
 
We would be suing David Lucchino directly, not the LLC. Even then, since the LLC merged with Korro Bio, it is possible that Korro could also be held liable. However, in reality, Lucchino should be the one held responsible for his misleading statements, not the LLC.

So far, neither case has progressed because only two people have filed lawsuits against him. We need more participants, which is why it is called a Class Action.
Honestly, nobody's interested in risking further losses or wasting their time. Good luck with your initiative to find people to take part...

Time to close the book on Frequency Therapeutics.
 
I lost a ton of money on FREQ as well. If I recall correctly, the placebo group showed unprecedented improvements, which likely means some participants were dishonest about their scores. However, there's no reason to suspect any deceit on the company's part—they genuinely believed their product would work.
 
The product apparently worked amazingly well in vitro (cochleas that were removed). But it ended up not working in vivo (in alive people). Maybe there was an issue with delivery but unfortunately they ran out of funding before they could figure out how to get it to work in vivo.
 
I am not sure what their in vitro results were—if they even had any. In the end, they could not demonstrate anything in vivo. Honestly, I never believed it from the start. It seemed too sensational, something that would have turned the world upside down. Even billionaires today have to rely on hearing aids.

I do not believe that Numelicina will ever be able to regenerate hair cells in people. It seems absolutely impossible. The whole stem cell concept, in this case, feels like pure charlatanism. I am very sorry to say this.
 
@lymebite, are you referring to FX-322, FX-345, or both? If what you say is true, then they should not discard the data. Someone in the future might discover the equation, delivery method, or "magic potion" needed to make it work in vivo.

But sinking another billion into this?
Jay, I am not sure.

At the very least, they should preserve the files and meeting minutes. Better yet, they should publish the findings. Who knows? Something valuable might come from it down the line.

Progress can be heartbreakingly full of near misses.

Perhaps the government should require, as a condition for receiving research grants, that companies publish their findings, methods, and results after an agreed-upon time span.
 
@lymebite, are you referring to FX-322, FX-345, or both? If what you say is true, then they should not discard the data. Someone in the future might discover the equation, delivery method, or "magic potion" needed to make it work in vivo.
The scientific discovery of what worked in vitro forms the underlying foundation for both compounds. Researchers discovered molecules that could regenerate cells in the intestinal system and had the idea to apply these findings to other parts of the body. They explored several possibilities and decided to focus on hearing and cochlear regeneration first. This was all before the compounds were named FX-322 and FX-345.

Thomas Edison famously said, "I have not failed. I've just found 10,000 ways that won't work."

Unfortunately, breakthroughs in medicine often follow a similar path—it takes many failures to achieve success. The development process for medical interventions is also incredibly expensive, making it difficult to secure funding. In the case of Frequency Therapeutics, their original in vitro discovery showed such promising results that they were able to secure investor funding to conduct clinical trials. As we know, those trials were not successful, and the funding eventually ran out.

To my understanding, all of their discoveries have been published, so the science is accessible. In theory, anyone with access to a lab and the desire to do so could produce FX-322 and FX-345. However, patents, intellectual property rights, and other legal protections likely prevent another company from commercializing the compounds without obtaining proper permissions. Nonetheless, the scientific findings remain available.
 
The scientific discovery of what worked in vitro forms the underlying foundation for both compounds. Researchers discovered molecules that could regenerate cells in the intestinal system and had the idea to apply these findings to other parts of the body. They explored several possibilities and decided to focus on hearing and cochlear regeneration first. This was all before the compounds were named FX-322 and FX-345.

Thomas Edison famously said, "I have not failed. I've just found 10,000 ways that won't work."

Unfortunately, breakthroughs in medicine often follow a similar path—it takes many failures to achieve success. The development process for medical interventions is also incredibly expensive, making it difficult to secure funding. In the case of Frequency Therapeutics, their original in vitro discovery showed such promising results that they were able to secure investor funding to conduct clinical trials. As we know, those trials were not successful, and the funding eventually ran out.

To my understanding, all of their discoveries have been published, so the science is accessible. In theory, anyone with access to a lab and the desire to do so could produce FX-322 and FX-345. However, patents, intellectual property rights, and other legal protections likely prevent another company from commercializing the compounds without obtaining proper permissions. Nonetheless, the scientific findings remain available.
It's great to have some clarity about the background of the Frequency Attempt. Scientists sometimes get excited, and that's completely understandable—it's probably one of the things that makes their profession so engaging.

Now that I think about it, earlier this year, I posted a link to New Scientist, a glossy magazine, where the main article focused on the excitement within the scientific and medical community about several potential breakthroughs in the tinnitus and hearing loss field.

Excitement can be infectious. It spreads from the scientific community to the business world and even to venture capitalists. So, there's more excitement to come—great! Just be cautious.
 

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