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  1. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    According to this literature review paper from 2013, it's possible using endoscopy but not easy: Drug delivery to the ear
  2. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    The figure at the front of the publication shows two purple arrows, one trans-tympanic and one from the direction of the Eustachian tube. It's gotta come from somewhere...
  3. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    Details are in: Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries
  4. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    The first method takes a long time, but according to the authors, cochlear pumping is much faster. From the linked publication: "Cochlear pumping distributes drugs evenly along the entire cochlea within minutes"
  5. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    In a nutshell (from the pre-print at the posted link): "low-frequency air pressure oscillations applied to the ear canal at 4 Hz, which caused large amplitude (~ 80 µm peak-to-peak) stapes displacement" Unlike the other paper I posted a link to, the CP one is pretty readable.
  6. Auricle

    Frequency Therapeutics — Hearing Loss Regeneration

    This looks similar to what you are suggesting: Steady streaming as a method for drug delivery to the inner ear There's also cochlear pumping, which looks more promising to me in the mechanical category: Local Drug Delivery to the Entire Cochlea without Breaching Its Boundaries
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