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But that only applies to normal cells, no? I'm not a biologist so I genuinely don't know, but aren't progenitor cells a type of stem cell and can therefore divide more often? I mean, Frequency Therapeutics said that the ear's progenitors are kind of like close cousins to the intestinal...

Isn't that a bit optimistic? I think I heard somewhere that in the trials they had to lie on their side for 30 minutes.

No, he said that if the hair cells are still intact, FX-322 won't "reconnect" them. Only newly created hair cells attach themselves.

Hello CAgirl, im sorry to hear what happend to you. I wish i could write you a well thought out text to calm you down but sadly im not that great with words. However, i can give you this text by michael which helped me to cope. I got steroids one month after my injury so i doubt its useless...

In theory you should be able to fully recover. However, that depends on your ear still having functioning support cells. Without support cells the affected areas can't recover. You'd need to be at least profoundly deaf for that to happen though. We will see the limits of FX-322 after their phase...

No, FX-322 only regenerates hair cells and their respective synapses. So if the cells are still alive but there's synaptic damage FX-322 won't do much to help you.

The delivery gel is part of the drug, so yes. They would need to get it approved again. However, since it would be a reformulation this process is way faster (and cheaper).

By the way, assuming FX-322 doesn't cure tinnitus (which I find unlikely), wouldn't it at least mean that Lenire would be more effective? I mean on the picture we can see that people without hearing loss benefitted way more than people with hearing loss. I know Lenire was a disappointment...

In my opinion it's very promising. Just look at the results of the phase 1/2 study (that was conducted with only 1 dose). They also tested it on live human cocheas ex vivo and had good results. I think the only question left right now is not whether it works for hearing loss but whether it will...

I wonder when they'll start their trials in Europe. After all Astellas has the rights for the rest of the world so one might think that they're pressured to release it outside of the US just as fast. Hopefully they don't start their trials after they fully release it in the US. I don't want to...

Thank you all for the informative replies! So it really just activates the body's own innate ability to regenerate. It's like FX-322 is a surgical tool while competing approaches are more like hammers. It's also quite funny to me. Scam artists have always sold desperate people stuff that...

I dont mean it spiked for 3 days and then went down again. It kinda got progressivly louder over 3 days and hasnt gone down for 2 weeks now

It's logical considering FX-322 basically just activates the body's innate ability to regenerate. And since there's a process that regulates this regeneration and (mostly) keeps it from becoming cancerous in the rest of the body, the process should be able to do the same in the inner ear...

I intented to but I only caught the end :/ My brother graduated today so I got caught up.

I live in germany. My doc is an ENT who specialised in treating ear disorders. I looked up their site and apparently its targeting the "stellate ganglion"

It initially got a lot better (i lost my high pitched eeee and was left with non-intrusive whitenoise) but ~1 week agot it came back over 3 days. Right now its hard to tell what the trend is, but that might also be because its been only one week and obviously the cortison also caused some extrem...

To be honest, i dont really know. Its some stuff thats supposed to increase the blodflow to the inner ear as well as cortison IV for the first 3 days. I also additionally get some anesthetic admistered via syringe into my throat to numb a nerve thats responsible for controlling bloodflow. Im not...

Goddamn, my bad. It really would be ridiculous.Thankfully that was just a typo I meant 2026.

You have to consider that most people don't have equal hearing loss across all frequencies. Many people (including me) have good hearing in mid to low frequencies and a drop at higher ones. For those with a ski slope audiogram FX-322 is perfect in its current form. There is still critical...

Safe? No. Likely? Absolutely. Sadly we can't predict the future and making empty promises is the last thing anyone needs. But it does seem like most of the drugs that are developed at the moment aim for mid 2020s. It would be ridiculous if all of them fail, especially since most of them have...

I hope so. Im currently doing an infusion therapy because HBOT isn't available and my tinnitus is changing a lot. My doc told me thats a good sign and that hes optimistic

I mean im the living proof of the danger of getting slapped on the ear. Blew my eardrum and lost some high frequencies due to it. But id assume that in my case the slap was a bit harder

First of all you have to remember that the limited frequency range stems from the vehicle they use to deliver the drug, not the drug itself. So even if 1. gen FX-322 doesn't reach sub 6.5 kHz, there's guaranteed room for improvement with reformulations (as other companies already managed to...

Even if it fails, there are so many other drugs in development that I'm sure we're gonna get something this decade. Who knows, maybe you won't even have enough time to learn enough about biology before they're already finished. But honestly, they already tested their drug on ex-vivo cochlea...

Acute doesnt describe the severity. Acute means recently acquired (~3 months) Although there is no clear scientific definition of when tinnitus is acute and when it isnt anymore