Complex question: For patients with autoimmune inner ear disease, their immune system keeps attacking the hair cells. Let's assume that they take FX-322, the progenitor cells get activated, and the immune system targets the progenitor cells. The patient then takes more FX-322. Can it actually keep cycling in the sense of:
hair cells dies ---> progenitor cell is activated -->progenitor cell dies ---> progenitor cell gets reactivated.
To make this question more general, once an activated progenitor cell dies, is that the end? i.e. patients get another chance at avoiding acoustic truama, but not a bunch of them?
EDIT: From reading the website (and this was mentioned in the podcast transcription), the analogy here is that progenitor cells recycle in the gut every few days. I wonder if a similar process could occur in the ear.
Does the human body keep creating progenitor cells in the ear, or are they also a one time deal?