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Back in 2013 when my tinnitus journey began, you could not visit any tinnitus community without hearing about AM-101. At some point I started digging into the science behind the drug and its mechanism-of-action on the NMDA receptors i.e. the ones that respond to glutamate (the primary...

The rule of thumb I apply is to wear earplugs whenever I leave the house. It's only a matter of time before someone honks their car horn while you are in their vicinity or someone slams a door in your face. Going around unplugged is an accident waiting to happen... A worthwhile read (with a...

Seems like you have done a lot. The only things I can add to the list is to be consistent with ear protection and to have a read of the pubmed-literature regarding NAC, Pycnogenol, Taurine, Magnesium, Zinc, and Creatine. As for earplugs, there has never been a downside to using these, but there...

Seems like someone has thrown a curse at the inner ear pharma field. First Auris Medical, then Otonomy, and now Frequency Therapeutics. That's +10 years of developments wiped away just like that. Hard to believe...

Well, the efficacy of OTO-313 was evaluated using the TFI score (which is fully subjective). OTO-413 is evaluated using speech-in-noise testing (which is objective). But the result can of course be influenced in one direction (but not the other ) i.e. pretending not to hear something which...

Perhaps give Taurine, NAC, Creatine, Magnesium and Pycnogenol a go. Protect your ears whenever outside in an environment you can't control. You never know when a driver is going to honk the horn or when someone is going to slam a door in your face... Over time, your tinnitus may improve (by...

Pretty incredible that a full decade of clinical trials still hasn't yielded any tangible progress. That's pretty much all I have to say. Best wishes to everyone.

No, no impact on tinnitus in my case. Got the Pfizer shot (x 2) five weeks apart. However, this article looks into a three-patient case study where a COVID-19 vaccine is deemed responsible for the subsequent resulting tinnitus.

This thread was created more than five years ago (by yours truly) with no developments since then (as far as I know). However, earlier this year, an in vivo-study was released on RL-81 suggesting that the channel activator is effective at the preclinical stage. It would seem, therefore, that the...

Hmmmm... wrong... both the FDA and the EMA say that a 10 dB improvement is clinically significant: "With regard to Sonsuvi , the FDA and EMA have indicated that a 10 dB improvement in hearing thresholds is clinically significant, in line with clinical practice. However, no product has been...

It doesn't matter that those deficits are present – they will be omnipresent and will show up in both the before and after scenario thereby allowing you to "subtract" two population averages from each other. The way you phrase it seems to suggest that a certain deficit will only show up in one...

The reason that the interim analysis showed the study failed (even though WR scores improved) is that when WR scores (also) improved in the placebo group (which serves as a reference point), it makes it that much harder for the drug arm of the trial (i.e. those getting FX-322) to demonstrate an...

The example you provide compares two different pieces of equipment (it is quite obvious from the readout that the testing was done in different places). This is a separate case. Even if there is a margin of error of ±10 dB, testing done using the same equipment will still have the capability...

I agree: any person in their right mind wouldn't go through all the trouble it takes to set up a biotech just to be a fraud. Fraud in business falls into two main categories: Those intending to be a fraud from the outset (example: Ponzi Scheme, Bernard Madoff). Those who run an honest company...

I wouldn't worry about it, but also not likely to help. For supplements, try Creatine, Pycnogenol, Turmeric, and Magnesium. Perhaps also NAC, Zinc, and Taurine. Avoid foods loaded with MSG (Monosodium Glutamate) – but not super important (i.e. will probably only spike tinnitus). Protect your...

I had no idea what 3-MMC was until you mentioned it. Having looked it up, I understand that the drug acts as a dopamine stimulant, and, anything that increases dopamine levels can also affect tinnitus – this is the domain of Prof. Rauschecker's tinnitus research. Having said that, perhaps a...

Perhaps look into supplements like Magnesium, NAC, Pycnogenol, and Zinc. Do an Internet search of the various terms in combination with "pubmed" to become educated on the topic. Perhaps do some brain training. Remember to use earplugs and continue to do so. And be disciplined about it: small...

Usually, I always lean towards noise exposure as a culprit when folks tell their story on Tinnitus Talk. But, in your case, perhaps consider the complications from an epidural (if applicable...).

A trip through an MRI scanner can take your existing tinnitus to a whole new level. Be sure it's what you want.

At 3:04 (in the video) the audiologist begins to dissect the second difference between the Wenzel study and the clinical trial related to OTO-313. He seems concerned that a "single injection" (of OTO-313) would be insufficient to deliver a high-enough dose of Gacyclidine (and thereby he pretty...

If he firmly believes in his message, then it's probably a consequence of his self-delusional traits. Suppose the advice @Michael Leigh dispenses ad nauseam here on TinnitusTalk was actually validated through his own experience, then I could at least tolerate his presence on a public forum...

Well done. This appears to be an important piece of advocacy that no doubt took a lot of hard work and dedication. Good to see some concrete suggestions for future deliverables (rather than umbrella terms such as "more funding" or "more research" required). I am guessing this should say "Leader...

I am surprised @Michael Leigh hasn't already left his trademark comment indicating "reactive tinnitus" is not a thing, but something made up on tinnitus forums. His fixated one-track mind is usually quick to pick up on these discrepancies – and this thread has been on-going since +6 months by now...

Newbies have a tendency to over-complicate the plot and search every avenue for answers: however, more often than not, noise exposure is the culprit. Reading your story (and background), my two cents is that it is not allergy related in your case. When it comes to loud events, there is a...

Well, there is a difference between the peripheral and the central nervous system. Also scar tissue plays a role. Some nerves do heal, and indeed, promoting regeneration is what cold laser therapy aims to achieve in such cases (for instance, search literature on e.g. Bell's palsy). However...

Indeed.

When it comes to tinnitus, there is essentially no difference between a good and a less regarded ENT. They are all equally unable to help. And they all equally cherry pick information to suit the patient situation (or their own situation, for that matter). However, for those interested in what...

Well... my input: title is misleading (i.e. "Tinnitus Retraining Therapy Is Ineffective, Latest Study Finds"). The study didn't conclude that TRT is ineffective – it found that TRT proper is no more effective than the two other treatment arms. It never compared TRT to doing nothing (control...

Well... given that the average donation per tinnitus sufferer (not to mention general engagement) is way less than for other medical conditions, I would say that no one – incl. tinnitus sufferers – seem interested in stopping the noise. So... in a sense, not only are you flying solo, there is...

Examine your patient history and you will eventually come to a conclusion containing substance that cannot be revealed by objective tests. Any and all assessments that are currently in use by physicians cannot diagnose tinnitus objectively. So... have a review by yourself of things like: Noise...

See a lawyer as early on as possible while the incident is still fresh and witnesses can be asked to make a statement. The "organization" is not your friend in this matter (however supportive and friendly they may appear to be...). The moment an employee cannot work or becomes a financial...

Noted. But those criteria above, do not relate to chronicity or severity (which was what I was addressing; I guess, I could have been more clear about that, sorry).

The Otonomy team themselves experienced the difficulties related to conducting a clinical trial based on subjective assessments (as was the case with OTIVIDEX). I covered it here. Bringing tinnitus treatments to the market is a problem due to the inability to define a standardized patient...

It's been a while since I have shared any pharma news here on the forum, but today, Otonomy held its Q1 2019 conference call on the results for the period while providing a business update at the same time. The update was designed so as to have a special focus on OTO-313 (a treatment for...

An article by the Daily Mail has shed light on gender differences when it comes to those suffering from severe tinnitus. A Swedish survey – which is the basis for the article – found that women who suffer from severe tinnitus are at increased risk of attempting suicide (compared with men). The...

Even one concert can cause tinnitus, hyperacusis, and hearing loss. Permanently. If you go to concerts (regularly) and listen to all genres of music, you have noise exposure that easily could be damaging over time. A go-with-the-flow attitude means that lots of folks end up being part of the...

No.

Indeed, the same could happen to FX-322. But... if it did, it would be for entirely different reasons. AM-101 "failed" (as in an "inability to prove efficacy") because of factors like enhanced placebo-response and lack of standardized patient profiles (because tinnitus cannot be objectively...

The trouble with some agents leading to ototoxicity is retention in the cochlea – here are two examples (concerning aminoglycosides and cisplatin): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640705 https://www.nature.com/articles/s41467-017-01837-1 So... drug half-life is not necessarily...

I think you can extend your observations to other variants of the Internet, like... forums – incl. tinnitus forums! Certainly, TinnitusTalk has a few regulars – who – are fairly eager to let everyone know that they have habituated – thereby triggering their much-needed attention from other less...

"Incredibly unlikely" (as an event) or "incredibly unlikely" (as a cause)? In the case of a known acoustic trauma, ear fullness is an expected outcome. Why? [Hint: the process involved starts with an "o" and involves the cochlea – what is it?]. Bottom-line: why look for the least likely causes...

Indeed: both you and your ENT have some reading to do...!

For once, I agree with everything you say. Except the last sentence...

Indeed. However, dichotomies exist not only in relation to the age-old debate about protecting or not protecting (sounds almost like sex education!) – "schools" relate also to those who rightfully vent their frustration and then to all those who spend their entire existence on TinnitusTalk and...

Why would you have been using white noise generators for 23 years... ...if you are already fully habituated??? Makes no sense. Tell me @Michael Leigh... what does it feel like inside your self-deceiving mind??? Well... it is certainly possible that you made it worse. Unlike @Michael Leigh...

Thanks for your... ahem... informative essay. I suppose it is possible to surmise many things about you. However, one particular point I feel fairly certain about is that... tinnitus is not your only problem. Perhaps it is even the least of your problems... Good luck to you.

You trust(?) the judgement of a borderline senile member who spends his entire life – day and night – on TinnitusTalk claiming he is habituated while writing the same mantras over-and-over again, like: ...I habituated twice to my tinnitus using TRT: the first time took two years, the 2nd one...

For more than one reason, I am indifferent as to which candidate receives the money. As I see it, the best outcome that could arise from this exercise would be if the chosen researcher is supported over a number of years – essentially becoming a "financial protégé" of TinnitusTalk. Of course...

Given that as much as 90% of tinnitus cases are noise-induced, I am not sure what role a physical therapist might have in providing a resolution. The typical reason a patient might end up in the hands of a chiropractor or physiotherapist is that ENTs are unable to diagnose a (noise-induced)...

That percentage split seems in line with the average online tinnitus community if you ask me...

Yes... I am beginning to see how the business model might work: you listen to the awful soundtrack and when you are done with the file and take the headphones off, it feels like you have no tinnitus at all (simply because any tinnitus – no matter how bad – is better than listening to that stuff).

Given the degree of your senility, the degree of your inferiority complex, as well as your apocalyptic display of self-deceit, the very last thing you should be engaging in is counseling others. If you really have so little to attend to that you have time to counsel others, why not come out of...

Well... I guess your own subsequent line explains everything doesn't it...?

Evolution only plays a part when a medical condition prevents an individual from having children (e.g. because of premature death). Getting rid of defect offspring is Mother Nature's way of keeping the gene pool clean. But that doesn't apply to tinnitus (except in the case of early suicide)...

@Michael Leigh – I have not read your lengthy essay as what you have to say is at best unimportant, but most often just plain annoying. However, I would appreciate you didn't use terms such as "complexities" as in the title of this thread – because if there is one thing your one-track simplistic...

Meanwhile at the NHS as we approach the end of the year...

Well... I am not up-to-date, but unless something has changed significantly, the legend is as follows: blue = normal member bold blue = physician bold orange = benefactor bold pink = staff dark green = special advisor (You will have to search pretty hard in the Internet archives to find an...

Very common complaint. The TRI flowchart remains the best resource there is: https://www.tinnitusresearch.net/index.php/for-clinicians/diagnostic-flowchart Consider your patient history as a reservoir of knowledge as to what might have caused your tinnitus (e.g. noise exposure, ototoxic...