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I've just reread the entire thread and didn't see any mention of somatosensory tinnitus being reduced by using Lidocaine patches. There was a question from @Ear Drummer above regarding this topic. Do you think these patches could help people like me who have noise-induced tinnitus along with...

Hi @Hazel: Regarding funding for new research, could funding be established for projects that have just begun? Will this funding be limited to private companies, or could public institutions also benefit from these donations? Additionally, could researchers working on a molecule (drug) receive...

Interesting study, @Frédéric, thank you for posting it. Do you have any information about their future work? Will they conduct tests on humans in the future? The researchers mention neuroinflammation. Could we draw a similar connection to Sound Pharmaceuticals and their research into Meniere's...

Very good point, @ErikaS. In addition to sound that exacerbates tinnitus, how could electrical stimulation of the inner ear help reduce tinnitus that reacts to somatosensory input, such as jaw movement (TMJ disorder), cracking of the eustachian tubes, tension in the tensor muscle of the soft...

@Hazel, in addition to funding research into tinnitus, could there also be efforts to create awareness campaigns in multiple languages? These campaigns are crucial to raising awareness of conditions like tinnitus and hyperacusis, which both the general public and healthcare professionals often...

Do we know if the patients whose tinnitus did not reduce after the treatment could modulate it using neck and jaw movements? I can't remember, but I think the study did include this type of patient. I'm asking because it's possible that symptom reduction worked better in people who could...

Thank you for the interesting information, especially about Botox on the jaw muscles, which reduces the intensity of tinnitus. I'm planning to have Botox injections. I'll inform you of the areas of the head and neck where the Botox will be injected. For the Eustachian tubes and their...

In addition to discussing Prof. McNaughton's own research, what is his opinion on somatosensory tinnitus, which can worsen? Does he share the view of other researchers that tinnitus is located in the cochlear nuclei and the brain stem, which is why some people experience an increase in symptoms...

What are the reasons for this? Is it challenging to work on?

Can botox reduce chronic somatosensory tinnitus? Do you have any experience of botulinic toxin ?

@Hazel, congratulations on your commitment and presence at the Tinnitus Research Initiative conference in Canada. Time passes, and for years now, it has often been said that the genesis of tinnitus lies in the brain stem and the cochlear nuclei. Is this really the case? If so, at what point...

Thank you for your testimonial. You say you have problems with your jaw, neck, and Eustachian tubes. Does this make your tinnitus worse? What are your symptoms with your Eustachian tubes? Cracking or popping when swallowing? I'm asking because Botox injections on the palate can reduce this...

When you talk about peripheral tinnitus causing you pain, is it somatosensory tinnitus (jaw, neck, Eustachian tube, etc.)? Or is the tinnitus linked to contractions of the tensor tympani muscle, in reaction to external sound?

What is your opinion of Arnaud Norena's hypothesis? I have pain hyperacusis with contraction of the tensor tympani muscle at various sound frequencies, even at low intensities. So if there's a contraction of the middle ear muscles, it must be linked to Arnaud Norena's theory? Or could it also...

In addition to the somatosensory tinnitus from your jaw, did you also have somatosensory tinnitus related to the neck muscles (SCM), cervical and Eustachian tubes? If not, are you better today?

I'd like to know if there's a possible link between contractions of the tensor tympani muscle, which also causes pain in and around the ear and in the head, and Megan Beers Wood's research. Is this different? Can we have an answer to pain in the inner ear (Megan Beers Wood theory) and...

Hello @Christiaan. Dr. De Ridder's comments suggest that it will be difficult to find a single cure for tinnitus. Tinnitus increases or worsens via the auditory inputs, the somatosensory inputs (trigeminal nerve, dorsal nerve, etc.), or even via the emotional pathway (sudden stress, for...

I haven't tried it yet.

My tinnitus is very strong because of eustachian tube dysfunction in addition to my painful hyperacusis. Have any people found solutions?

Hello @Hazel. I can suggest five subjects that might be of interest. The first is by Stéphane Maison, Charles Liberman, Neural Signatures of Tinnitus in Subjects with Normal Hearing. It would be interesting to find out a bit more and ask them what solutions could reduce the cerebral...

This type of study has been carried out frequently for some time now. I hope that serious protocols (like Dr. Shore's) will be put in their place and published. The aim being to reduce hyperactivity in the cochlear nuclei, brain stem, etc.

Have you always improved from Ajovy (Fremanezumab)? Do you also suffer from hyperacusis? If so, what was the pain like? In the tensor tympani muscle? Thank you. The results should be out in the next few months?

When you talk about the peaks in the DCN, are you referring to a similar aggravation of tinnitus via the trigeminal nerve with, for example, dysfunctions in the neck and jaw? I mean that if TMJ problems worsen, the tinnitus (somatosensory) already present will also increase in volume?

Can my jaw problems aggravate my painful hyperacusis (TTTS) and the intensity of my somatosensory tinnitus? The main cause is sound trauma

What does XEN1101 have to do with GABA?

I have a problem with my Eustachian tubes in addition to my pain hyperacusis and tinnitus. I've noticed that my somatic tinnitus is reactive to Eustachian tube cracking, which has become chronic. I think that my pain hyperacusis (contraction of the tensor tympani muscle) also increases with...

With regard to Megan Beers Wood's research, could the contractions of the tensor tympani muscle that cause pain be linked to the inner ear? It would be interesting to know what type of symptoms correspond to Megan Beers Wood's work (inner ear) and Arnaud Norena's research (middle ear). Could...

I have a question about tonic tensor tympani syndrome and/or contractions of the tensor tympani muscle in relation to sound. Can the increase in tinnitus when there is sound depend on contractions of the tensor tympani muscle? Or are these increases more related to the inner ear and the...

I'd like to hear from people who have used Botox on the tensor palate muscle and the masticatory muscles of the jaw, the temporalis muscle, the sternocleidomastoid muscle and other muscles that may play a role in contractions of the tensor tympani muscle (pain hyperacusis) and somatosensory...

Have any studies or research been carried out into a possible link between increased Glutamate levels via sensory pathways other than sound (movement of the neck, jaw, etc.) stimulating/increasing tinnitus that is already present?

I also have Eustachian tube problems. It's possible that they accentuate the (pain) hyperacusis by aggravating the contraction of the tensor tympani muscle. They are also linked to the jaw muscles and the tensor palate muscle, which, if contracted too much, can affect the Eustachian tubes. But...

In a month's time, it will be a year since the Palm Springs Hearing Seminar with the presentation of Dr. Shore's interesting results and device. Time flies... It's incredible that no health professionals, health organisations, media, associations, patients or forum members have any information...

I have read here that these channels are located in the cochlear nucleus. If I'm wrong, please correct me.

There was a new update on 2 October. Recruitment is still underway. The trial is due to finish in May 2024, not this month. An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus - Full Text View - ClinicalTrials.gov Can anyone here contact SAGE Therapeutics to find out more?

With regards to pain hyperacusis, how could a drug such as BHV-7000 (Biohaven) improve it? The most likely hypothesis for pain hyperacusis is a degeneration of the cochlear nerve fibres in the inner ear. The opening of potassium channels would be in the cochlear nucleus, which is different...

I don't live in the United States but I'd like to know what the American Tinnitus Association thinks about Dr. Shore's device? I suppose they know about it?

In addition to your painful hyperacusis, do you have somatosensory tinnitus with neck or jaw movement? Do you have problems with your eustachian tube? This is a question about botox treatment and TTM contractions.

Sorry about your tinnitus. I hope it goes away. Regarding physical therapy for your somatosensory tinnitus, could you please keep us informed? I think this is in line with Sarah Michiels' studies with her team on this type of tinnitus. Supposedly, she has found manipulative techniques that can...

Thank you Christiaan. I don't want to misinterpret the results. Could someone tell me whether, on the whole, Retigabine was satisfactory in terms of reducing tinnitus or whether it was insufficient? Participants which used therapy N: 53 Big improvement N: 15 Small improvement N: 18 No...

Does anyone have a link to a video or file for physical relaxation exercises for the neck, cervical and eustachian tube muscles?

Hi @Markku and @Hazel, Concerning the old topic in which members of Tinnitus Talk used Trobalt (Retigabine), I'd like to know if you were able to summarise the success rate at the time? Taking into account the type of cause of tinnitus with or without pain hyperacusis (sound trauma, for no...

Are you feeling better after taking Cyclobenzaprine? In your opinion, does the role of this drug lie more in the muscle relaxant effect or in the brain and serotonin? With regard to the muscle relaxant effect, could Alprazolam have a similar effect to Cyclobenzaprine?

Hello @Hazel and @Markku: Do you think it would be possible for you to do an interview with Megan Beers Wood to find out more about this research and in particular about molecules that antagonise the alpha-calcitonin gene-related peptide (CGRPa)? Thank you.

Hello, I'd like to raise the subject of Botox injections in the muscles which, during contractions, may affect the Tensor Tympani muscle in pain hyperacusis. The literature mentions that the Tensor Tympani muscle is innervated by the Mandibular and Trigeminal nerves, i.e. by the muscles of the...

My nerves got the better of me last week My T, including somatosensory tinnitus, is stronger and more reactive to sound. What do you think?

Hello, Concerning RIMEGEPANT, a migraine medication that blocks CGRP receptors, have other people with pain hyperacusis tried it or would they be interested in trying it? @Diego LR, I can see that you're apparently the only one here to have tried it, but from what you've said, you have...

Has anyone tried this new Biohaven drug yet? It's a new-generation molecule that antagonises the peptide linked to the calcitonin gene.

Do you have any news on this? How many years will this research programme last?

The study should be completed shortly. I don't know how long it will take for the results to be published? In any case, let's not lose sight of this study!

Hello, I'd like to ask you a few questions to try and understand a bit more about the functions of potassium channels and BHV-7000. I see in the thread that DCN is linked to potassium channels. Is that correct? In other words, is there a dysfunction in the cochlear nucleus where potassium...

The 2nd International Kv7 Channels Symposium took place this week in Naples, Italy. Prof. Thanos Tzounopoulos was there, "Roles and mechanisms of Kv7 channel plasticity in hearing loss and tinnitus". Has anyone heard from him?

Was your tinnitus reactive to the sound environment (everyday sounds)? If a similar drug came out tomorrow, would you take it again? Thank you.

Thank you for this information @StoneInFocus. Does Megan Beers Wood's study correspond to Paul Fuchs' work? I assume it's the same team? In one of his first studies Arnaud Norena mentioned this: Could the CGRP gene studied by Megan Beers Wood in the inner ear be identical to the one found in...

Doesn't anyone have a neighbour who has a friend, who in turn has a cousin, who knows someone working at the FDA to quickly validate Dr Shore's device? :LOL: In any case, great work @Markku & @Hazel! I would have liked an answer to my question: "Would excessive (even involuntary) stimulation...

I am looking for links to publications by doctors/researchers on sound reactive tinnitus in the context of hyperacusis.

Speaking of neuroinflammation, Professor Sven Vanneste will be talking about it at the AFREPA conference in Toulouse (FRANCE) in September. Topic: tinnitus and neuroinflammation. It will be interesting to find out more after this conference.

My tinnitus is even louder, perhaps because my eustachian tubes crack when I swallow or breathe in.

That's a good question. I haven't been going to gym or outdoors in places where sound can be dangerous for years. But even if I do sports at home, stretching, exercise cycling, cardiac coherence, my tinnitus increases. As I have somatosensory tinnitus that is very reactive with my posture, I...

Any recent news about this study?