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See below link for a US Meniere's trial still recruiting by sound pharmaceuticals. Though this is a Meniere's study the brief summary says- This study will evaluate the safety and efficacy of three dose levels of SPI-1005 compared to placebo on vertigo, tinnitus and sensorineural hearing loss...

Read this to understand what it is and what it has the potential to do http://www.hearingreview.com/2015/06/new-drug-promises-relief-from-tinnitus-epilepsy/

Quite ironic that only in July 2015 they received and extra 8 million in funding, taking it to 23.5 million in total for series A. Charles large made this comment about receiving the funding only in July 2015 - "We are delighted that all Autifony’s investors are supporting us with additional...

You don't need to wait. This link takes you to their own page and you will find all the questions asked, and all the answers that they provided, and that was back on July 16th as well.

Research similar to this has been conducted already, using side effect network analysis, and the results are in the below link. It is quite an technical read but has some interesting points none the less. If nothing else at least you get a list of all the meds they used for this research and...

Seeing as you got the exact same reply as I got from them, and mine was from Nov 2014, I wouldn't say they were that good at responding either, they are obviously using set templates to reply to questions. I would suggest no one of any significance in the company would be looking at these...

Interestingly enough this company is looking into something to do with GABA and NDMA and says the below on their research program page Discovery Programs We are exploring additional potential products in a variety of CNS disorders based on modulation of both the GABAA and NMDA receptors. In...

Lots of speculation and guessing going on here for sure about time scales, so here is a copy of correspondence I had directly with Autifony during Nov 2014, when I asked a question about time scales for testing. Seeing as this is directly from Autifony I consider it to be useful information and...

See below, they basically allowed Autifony the rights to patented compounds and data in exchange for shares in Autifony GSK takes minority stake in new spin out Autifony Therapeutics 22 August 2011 This press release is intended for business journalists and analysts/investors. Please note...

Given the discussions about all the different Kv channels and what they can and cannot do and what parts they affect, according to peoples opinion anyway, here is an interesting document all about the Kv7 channels. I might have posted this already some time ago, but here it is again anyway...

If you want to invest in them, seeing as they are not self funded, you could invest in imperial innovations which has a 27.5 % share holding in them. The main issue being you are also relying on the other portfolio funds as well to perform, so the price could change depending on other results ...

I posted this link previously some time ago, but they now have more information on their site. Someone else looking at developing another drug to target areas, similar in working, to 063 http://knoppbio.com/research/show.php?2

I posted this link previously some time ago, but they now have more information on their site. Someone else looking at doing a improved version of Trobalt http://knoppbio.com/research/show.php?2

I posted this one some time ago, maybe there are others out there we don't know about yet. Have a look and see for yourself what they are looking into developing http://knoppbio.com/research/show.php?2

Came across this link for a trial to be conducted in the UK, for anyone interested, using Melatonin http://www.crd.york.ac.uk/PROSPERO/display_record.asp?ID=CRD42015022019 Also info on a previous trial using the same product http://www.ncbi.nlm.nih.gov/pubmed/21859051

Don't do face book myself but someone told me about the below link. Go down to July 16th and there you will see this site mentioned and a list of the questions and answers that they have on their page, looks like they have put it there rather than answer on here...

So just to add a bit of information, directly from Charles Large himself on this topic, back in 2014 I asked him this exact question and below is a copy of my question and his response via email. For those interested the link below explains what the ema's adaptive licence actually is...

Interesting info, the one below statement from him about Neuromonics is surprising, ( with lots of other statements disputing the device as well ) especially when you consider he was the vice president for clinical affairs for Neuromonics ( tinnitech ) for 2 years from 2002 - 2004, maybe his...

I find this style of reply to be a typical response from you to anyone who does not list TRT as their only way of looking at overcoming their issues. I happen to have an unbiased view when reading what people are trying on their journey to recovery, unlike yourself of course. I have read a lot...

It was quite clear what my question was and the reason why I asked it, yet the reply was that I was implying the person was a criminal, go and figure that reply out for yourself. At the end of the day if someone appears on here saying they have known about this site for 12 months, then joins...

So which part of my question suggested this, please elaborate ? Lets look at the facts, You suddenly appear on here saying you are on day 22 of this trial, nothing from you previously. You got asked a genuine question by Zmichael, to clarify a few things, and you did not supply an any...

Could I ask how you actually got on the trial then with this statement please, given the strict criteria set ? It seems you are saying you got on this trial without meeting the main strict criteria point for loss, and that is an issue / stumbling block for other people thinking of going for...

Is this comment speaking from personal experience, I don't ever recall you being on this stuff, so intrigued as to how you can state these two effects ?

Not having a go at you karwash, just using your quote to put this thing into context. In relation to the above quote, lets look at the facts shall we, 100 + pages of general discussion about this stuff, no issues without the Dr joining in, then all of a sudden the Dr joins in and it all goes...

As per usual, he comes on, tries to dispel any idea of something assisting people, other than the business he has an interest in of course, then leaves the thread, he does it all the time.

Another study project being looked into by Autifony and what their Kv3 compounds can target, wonder what else they are looking into using these compounds for ? http://www.findaphd.com/search/ProjectDetails.aspx?PJID=50043

You know a thread is getting way too long, so not practical to read, when things start to get repeated, I posted the below link for exacly the same article on page 61 of this thread. http://www.molecularpain.com/content/6/1/49

No This "proof-of-concept" study will explore the potential of Autifony's lead Kv3 modulator, AUT00063, to reduce the symptoms of tinnitus in people who have subjective tinnitus.

So on the powder supply route, I got some supplied and tested for quality and purity and here are the results.

oh well, who needs any other sort of assistance, we all just along to his clinic and we all get fine afterwards. Can anyone else just advertise their business interests on here at all ?

sounds like a statement from that joke of an organisation the ATA.

I thought you are on the 101 trial starting on the 3rd Nov, why not wait to complete that trial first ?

Mate I am sure you know a lot more about me on this stuff as you are all over this like a rash, but I have attached a page from GSK's own document showing what dose levels they did during the testing phase in case this assists you at all. The maximum total daily starting dose is 300 mg per day...

This was the chart you were looking for, shows slow taper up and only to max level of 600mg a day as well

This was posted way back so thought I would post it again, as this was a interesting power point presentation from Autifony themselves and might clear up some of your questions / thoughts about 063.

The USA FDA has a document which shows companies approved to supply the us market with drugs and similar products. Not surprisingly 70% of the meds come from countries other than the USA, and the top two, India by a long way 23.7% of total then China ! So anyone maybe thinking of getting...

some info on a product targeting the KV3.4 channel, might be of interest http://www.sigmaaldrich.com/catalog/papers/9506974

is it this one by any chance at all, I got prices off them recently, never went ahead with the purchase, but could be a way of getting this stuff for sure, if I change my mind ! www.merrychemical.com/sell-offer_retigabine_cas_no_150812_12_7-84312.html

read this document for the info you will need. www.tga.gov.au/word/auspar/auspar-retigabine-131017.docx also what supplier did you use, can you let us know at all ?

Came across this document, this company is looking at developing a newer style of trobalt ( still using ezogabine ) but more potent and has less side effects

Do you think it really matters that much that it is a neurology company, at least they are completing research into different targets. Maybe companies are now realising that these Kv channels can help out on lots of conditions. If you look at Autifony they say the below on their site...

You can invest in Autifony in a round about way, they are part the below listed company and they trade shares. It might be a good time to buy, they are down as of Friday. I suppose the only risk is you are also investing with other companies as well within Imperial innovations. If you have a...

Another company looking into a similar style of medication as 063, and they are also improving a trobalt style compound as well, to improve its safety and to reduce it to one a day dosing, the more that get involved the better the outcome. http://knoppbio.com/research/show.php?2 And this...

Another company looking into a similar style of medication as 063, and they are also improving a trobalt style compound as well, to improve its safety and to reduce it to one a day dosing, the more that get involved the better the outcome. http://knoppbio.com/research/show.php?2 And this...

i suggest you get a car the same as mine below, very economical and attracts the ladies no end.

There is a long thread already on this topic in the treatments section, i suggest you look there Amandine first.

Lep, I am just trying to ascertain what you mean by the above, do you think that by taking Trobalt, then stopping it, made your symptons worse in total than they used to be in the first place, or did it just go back to its "normal" level. I read about some people who say it is working and...

Would not read too much into that one mate, see below, they are all at it in some form. Where there are large amounts of money involved there will always be fraud and back handers going on, and that applies to all industries not just medical ! Pfizer[2]$2.3 billionOff-label...

posted this on the other thread, but thought this might be useful on this thread Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats http://www.molecularpain.com/content/6/1/49

Interesting article about retigabine and tmj issues for those interested Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats http://www.molecularpain.com/content/6/1/49

2 Interesting articles going into detail on these kv7 channels. Driving With No Brakes: Molecular Pathophysiology of Kv7 Potassium Channels http://physiologyonline.physiology.org/content/nips/26/5/365.full.pdf Pathogenic plasticity of Kv7.2/3 channel activity is essential for the...

Hey, maybe read this thread about this topic, might be useful for you https://www.tinnitustalk.com/threads/tinnitus-vs-tinnitus-hyperacusis-some-basic-differences.5110/

Here you go, get yourself a job working on the AUT063 trial. Its a fixed term contract until May 2016, could that be the end date of trials, just a thought ?

Here you go, get yourself a job working on the AUT063 trial. It is a fixed term contract until May 2016 could that be the end date for trials, just a thought ?

I knew i was right after reading the post once, unlike yourself of course, so no wrong assumption from me.

check your own before you comment.

Thanks for clearing this up, your original sentance explained this anyway.

The grammer of the sentance is quite easy to understand when written in the above manner, look at what she says, what do you think she says BUT for, followed by the word IF in the bottom sentance, the below is the sentance split up to make it easier to undersand so i have had t for 11 years...

Read the above how it is written, it is quite clear

Exactly my point, to lie just to get in will be so wrong for everyone else, they have a criteria for a reason and it isnt so people can try to get round it. Just let them do the tests exactly how they need to, and go from there. What would happen if everyone lied to get on this trial and they...