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nope. i would say it did help me significantly with hyperacusis and habituation.

i think that the people that got VS from RTG should open a communication line with each other not just for support but to somehow figure out what is common between your cases. perhaps there was a uniquely similar provenance of the RTG (a bad batch/manufacturer)? i would like to know how...

hi everyone, i've been keeping tabs on this thread for some time now but haven't posted. i posted extensively in the retigabine thread a few years back, and after 3 years with tinnitus have finally pinned down my issues as being neuromuscular. i have tmj, and excessive tension on the left side...

which nerve is he referring to? i'm guessing its the vagus nerve.

hang in there bud. there is a chance it goes away completely, but i guarantee you that your situation will get better. since you have intermittent t, you should look into tmj / neuomuscular etiologies. i am on keto in my 3rd year of t, and i think it helps - the diet is neuroprotective and...

its so hard to assess this very subjective phenomenon, particularly given the passage of time. given how great a part of the suffering was caused by the hyperacusis, the alleviation of that particular symptom itself (due to RTG) greatly reduced my 'level of t'. in terms of the loudness of the...

hi all, i have not been on the forum for awhile, just wanted to check in. as some of you may know i was one of the first trail-ees of the drug, well documented in this thread. as an update, i am doing fine with my t. i have had no long-term issues with RTG, and it has been 2 years since i...

ive been on the ketogenic diet for the last 4 months. i can't say if it helps or not for t (probably a little), but it definitely has eliminated my moodiness and mood swings. the insulin rise and fall can be an emotional rollercoaster, so i am happy to avoid that - it's just a steady dose of...

i'd suggest trying some from a different source just to make sure. this drug is pretty intense, i don't see how any nervous system can escape from feeling something.

3 weeks. 300mg tid to 400mg tid was marginal improvements experientially, but i was pretty drugged so who knows. but 200mg tid to 300mg tid was a huge difference.

leon, i just read your user experience. is it possible you have an unreliable batch of pills? some have noted differences in pills they got online vs from a pharmacy. it seems very odd that you would feel nothing at 350mg tid.

i didn't feel anything until 300mg TID. a 200 mg pill did nothing for me. i think you should wait till you get to a 300mg TID or 350mg TID to draw any conclusions. good luck.

In Tzounopolous' recent HCN paper there is a section addressing the limitations of this model. I don't think the conclusion is that the model is not useful. My opinion is that the 0063 compound didn't work because most people's tinnitus is not centered around their cochlea (a relatively passive...

400mg at one time is the optimal therapeutic dose for a short course. i stayed on that for three weeks, some people have stayed for less or more. waaaaaay back in the beginning of this thread you can find a detailed post i made regarding effective dosage (with graphs and charts). you can go...

insufferable. not a single person on this thread has been playing doctor. everyone is simply providing their opinions, and on a good day some evidence as well. you are tilting at windmills, you might want to get off your high horse.

i did two courses of am-101 (the second had the real drug). i didn't note any drastic improvement (unlike RTG), and now going on 2 years later, i regret having done it. the entire thing is a big ordeal, and having injections in your ear, while safe, is not fun at all. given the wide etiological...

yes. i suppose people aren't responding because its quite a personal question. perhaps you would be better served PMing individual trial members. in fact we should probably set something like that up. if i recall correctly @Christian78 said that it effected him in that way. i can't speak for...

Very good data research, thank you for that. Regarding the QT issue, it is not a big issue with RTG. If i recall correctly, it is Kv7.1 are the receptors which are in almost exclusively in cardiac cells, and the effect from RTG on them was very weak (it was even thought that RTG has no effect on...

its possible that RTG has a much greater therapeutic potential in the acute stage, whatever your subjective level of t is. the same could be said of any intervention for recent onset t (such as AM-101).

looks good. i'd say also that if you are not feeling anything at 100mgx3 or 150mgx3, you can probably go up faster. once you have an effect, then taper up the normal way (every five days).

nothing has been proven @nills. sorry it didn't help you but it has helped other people on this forum (including me). what i don't get is why people want to generalize their own experience with (and limited knowledge of) the drug, in an effort to dissuade others from trying something which may...

anyone have any info on why EARS has jumped so high in the stock market?

i like the idea of a fast taper up. it's what Mpt did. you are trying to undo the pathogenic plasticity. i like zimicheal's analogy of 'busting the doors down'. 2 months might be a bit long, i would try for a month or so on that dose and see if anything significant is occurring. i think...

hey there ateos. great points as always. my trial lasted roughly 8 weeks. i did a fast taper, i reached 300mg tid in about a week, and stayed there a week. i went up to 350mg tid a week later, and then 400mg tid a week after that. i think i felt some improvement when i first took the 300mg...

are you feeling any side effects? i remember a few times taking RTG and not feeling anything, but that was rare. it's a pretty crude drug (not very selective), so i am sure there would be some effect, at least some of the time on your t. even if your t was localized in your auditory cortex...

I didn't feel anything until i ingested a 300mg pill. 100mg truly is nothing, and once you are finished metabolizing it (8 hours), it is gone from your system. i've written before about the tapering protocol- it was meant for epileptics, for which this drug is meant to be something they are...

does anyone know if auris will tell us if we got the placebo or not for the first trial? i would like to know. i took it in may 2014.

They definitely have some effect on the brain and may effect the t levels, but I doubt that it does so in a permanent fashion. I was wondering though if you could expand on this, rather strongly worded claim: "Given that the current neurological model of tinnitus strongly implicates dysfunction...

interesting. this is the first i've heard of cannabinoid receptors being the issue. the DCN is definitely ground zero for (most) tinnitus, but i've only read about the K receptors being the issue (Dr. Tz's work). i am sure that the picture will be much more complicated than that, and many other...

I think if you have the form of T which is a constant sound which never fluctuates, i don't think RTG will work. I am guessing that you may have this form of T @Bart. This indicates that the hyperactivity originates in the auditory cortex itself. I think most people have a fluctuating T, where...

i agree with needing to go to a high dose, but i think some people are tapering up way too slow. you want to undo the pathogenic plasticity, and slow moves are less likely to counteract the (new) homeostatic response than big ones.

also wanted to add that i have been on the ketogenic diet for the last 4 months, and i am quite sure that it is helping. the literature on that is quite vast, i'd recommend looking into it. it is a diet that is recommended for epilepsy.

use the search function and find my posts in this thread and the user experiences thread.

this is pretty incredible. anyone have any ideas about what might be going on here? at the very beginning of this thread, some people (@Zimichael , @benryu) discussed the possibility of using GABA medication to augment/solidify the effect of RTG, but i don't think anyone ever tried, till now...

while this is true, i am sure danny would tell you that the stark contrast between his T experience before and after intervention with RTG is salient, and revealing. i can tell you from my experience it was a stark contrast. while there were some gradual improvements over the 8 months of T i had...

this is a good synopsis, but I think the HCN channel involvement is pretty exciting. I found two quotes to be informative: "our results suggest that it is the recovery in KCNQ2/3 channel activity, not the lack of reduction in KCNQ2/3 currents, which is linked with the resilience to tinnitus."...

for the two months that i took it, i was not able to do anything very complicated. thankfully it was a very slow two months at work, and i worked from home. i think ideally you should wait till your break, set aside 2-3 months of your life for this trial, and do it right.

yes, i am a pretty big guy (was around 220 lb when i started). i didn't feel anything much until around 250mg three times a day. it really kicked in at 300mg three times a day, but i really don't think weight makes too big a difference. i think everyone should start at at least 100mg three times...

this thread has degenerated. i think trobalt is a great idea, and dannyboy has done some work towards encouraging some others to try it out, but my god does he need to self-censor a bit. don't just post whatever comes to your head! i remember when i came across this thread around this time last...

here is a recent update from Autifony.

here is a new document that a pretty good overview of the entire pipeline of Otonomy. Pages 5, 20, and 25 specifically relate to OTO-311.

update with me: t is still low, and is not much of an issue with me anymore. i don't notice it much, and when i do it doesn't bother me. good to see that other people are joining in our informal trial. i would urge those that are starting this drug to do a search on this thread for my posts and...

i know of at least one person that went with a chinese pharmaceutical synthesizer (certified by the CFDA - chinese food and drug administration - for what its worth). this person confirmed from a professional chemical analysis that it was 100% pure (retigabine). and it looks like the...

i guess @dan 's statement was ambiguous, but i took it to mean he was inquiring about SF0034.

the correct answer is: No SF0034 showed >10 times higher IC50 values for hERG inhibion, which indicates that SF0034 is less likely than the parent compound to cause hERG-inhibion-related QT prolongation. explain yourself @Nucleo

@attheedgeofscience has requested that I post this relevant paper for him.

From the recent Tz paper on SF0034: "Although the mechanism by which retigabine generates toxicity to the skin and retina remains unknown, these toxicities occur in organs that are exposed to light and UV radiation. Elevated exposure to UV radiation by causing photodegradation and oxidation of...

this drug seems like you could take it and go about your day (hopefully with some appreciable effect on your T). trobalt made most tasks very difficult for me. also, since we know the chemical structure of this drug, it may be possible to get a chinese synthesis of it. i wonder if it SciFlours...

also, that bit about it hERG is cool. hERG is a cardiac Kv channel, so this will eliminate whatever heart issues people had, although from my understanding the threat to the heart was not too big an issue at the dosages we were taking.

great work @attheedgeofscience!

@valeri it looks like given your constraints, what you want to accomplish is a sense of whether or not the drug will work for you. to that end i would ramp up as quickly as possible, and taper down even faster. i don't think slow taper down (or up) is important at all, i think that is mostly...

yes and yes. please read my user experiences. i am getting a lot of the same questions from people in my inbox. i have done a good job in this thread of documenting my experience with the drug.

i'd say more than 6 months and you might be courting the possibilities of long term side effects. this drug has been prescribed and has been used by people for years though, but that is for epilepsy which is much different from T. i chose 3 months, slightly arbitrarily i suppose, but i...

its been 4 months since i stopped RTG and all my faculties are 100%. regarding the fast taper, honestly i think you will have side effects for the first week or so just simply from the fact that you are taking this novel drug in your system. i don't think dosage plays as big a role as you think...

i agree with your doctor. stay the course. the side effects aren't that bad and i seriously doubt anything is wrong with your kidneys (maybe you are drinking too much water). you will start to tolerate it better towards the end of the second week. and then you should only be on this for a few...

Trobalt only works on Kv7 channels, it does not work on Kv3, or any other K channels. I only ever read one paper which briefly mentioned that it has some slight effect on Kv3 channels, but not in any meaningful way.

i agree, H and T are intertwined. I in fact did not know i had hyperacusis until i took RTG. I just though the pain I was experiencing was simply a part of what tinnitus is. when I took RTG, it sort of isolated and purified the sound, and allowed me to sort of observe it dispassionately with the...

i would say we have had quite a lot of people that have started on this drug, but we have not heard from many of them. would anyone like to volunteer to compile a list, to update the one that @rtwombly compiled many months ago (it is a sticky on the first page)? i would really appreciate it if...

@Danny Boy, @Juan Carlos, and myself have had lasting improvements on 400mg, but I would say that you would need to go up to at least 300mg to really see what it does for you. i think there is way too much unfounded fear of this drug. i did a ton of research on this drug before i took it (look...