New Study on Trobalt/Maxipost in Relation to SHL-induced Tinnitus

[attheedgeofscience]

The following very recent finding from an animal model may have implications for Trobalt and its therapeutic potential on the treatment of symptoms of tinnitus. I will try to find out more.

Potassium ion channel openers, Maxipost and Retigabine, protect against peripheral salicylate ototoxicity in rats.
Sheppard AM1, Chen GD2, Salvi R2.
Author information

Abstract
Sodium Salicylate (SS) reliably induces a sensorineural hearing loss and tinnitus when administered in high doses. Recent animal modeled studies indicate that potassium channel openers such as Maxipost and Retigabine (RTG) can block SS- or noise-induced tinnitus respectively; however, the origins and mechanisms are poorly understood. Since SS blocks the same potassium channels that Maxipost and RTG open, we postulated that these drugs might influence peripheral auditory function. To test this hypothesis Maxipost or RTG were administered alone or in combination with SS in rats. When administered alone, Maxipost and RTG had no effect on distortion product otoacoustic emissions (DPOAE) or compound action potentials (CAPs). However when Maxipost or RTG were administered with SS, Maxipost prevented the SS-reduced CAP amplitudes at high frequencies (≥20 kHz) and RTG prevented SS-reduced CAP amplitudes at low frequencies (≤8 kHz). These results suggest that Maxipost and RTG can protect against peripheral damage and therefore reduce the incidence of tinnitus.

Copyright © 2015 Elsevier B.V. All rights reserved.

Source: www.ncbi.nlm.nih.gov/pubmed/25937133

 

[Philemon]

Here's the article if you need it

 

[nills]

from article

"RTG would suppress low-frequency tinnitus, 123
while Maxipost, in contrast, would suppress high frequency 124
tinnitus. Since SS is believed to induce a high pitched tinnitus 125

 

[erik]

Sounds like a preventative treatment rather than one for chronic T....or am I reading this incorrectly

 

[Nucleo]

Sounds like a preventative treatment rather than one for chronic T....or am I reading this incorrectly

Yeah from the way this is written it sounds like that.

However the take home message is researchers show playing around with K+ channel functions directly affect the auditory system of animals after it is damaged. This shows more promise than anything else really.

 

[erik]

Yeah from the way this is written it sounds like that.

However the take home message is researchers show playing around with K+ channel functions directly affect the auditory system of animals after it is damaged. This shows more promise than anything else really.

Let's hope so. They have been talking about Potassium channels and T for years now and they are still playing around with mice and chinchillas. I found articles linking this over 7 years old now

 

[attheedgeofscience]

Sounds like a preventative treatment rather than one for chronic T....or am I reading this incorrectly

The reason I posted the information further up was because the animal-study was brought to my attention by the Tinnitus Research Initiative which has submitted a manuscript to the journal "Expert Opinion On Pharmacotherapy" based - in part - on participants who volunteered their experience with Trobalt as pertains to efficacy in relation to treatment of symptoms of tinnitus. The animal-study may help explain why some participants of the informal trial here on TT saw better improvements than others re:

"However when Maxipost or RTG were administered with SS, Maxipost prevented the SS-reduced CAP amplitudes at high frequencies (≥20 kHz) and RTG prevented SS-reduced CAP amplitudes at low frequencies (≤8 kHz)."

The above, therefore, represents a dichotomy in the treatment potential and could be explored further either retrospectively, or going forward with other volunteers.

The reason I posted the article had nothing to do with the basic overall efficacy of Trobalt, but instead because of the specific finding as quoted.

attheedgeofscience
12/MAY/2015.

 

[locoyeti]

@attheedgeofscience has requested that I post this relevant paper for him.

 

[Atlantis]

It's good rats get relief from tinnitus!