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I apologize if I in any way derailed the thread with my quirky approach to joining this thread. @Furetto, I think you raised excellent questions and started this conversation in a way that deserved serious replies. Allow me to do that and move past my past messages. Here is part 1 of probably...

@Alberte, hi! Yes, we do have feedback from a number of early customers. We want to share it but there are a few reasons we are waiting. 1—the emails I get from subscribers/customers are private. I don't want people to wonder if any part of their communication is going to be used for some...

Friends, I have been following this thread since last Saturday—carefully reflecting on all the excellent points that have been brought up, and... more importantly, adding all of you dissenting voices to my "Enemies of the Treatment Report" list. Teasing, of course. (There is no such list—yet!)...

Something very, very strange about this NHPN-1010 story. I will share an update soon.

I’m confused. Where did you hear this? Are you sure? My understanding is that Otonomy is the one making payments, as part of a licensing agreement. The agreement gives Otonomy exclusive rights to the patented compound (specifically for hearing loss). Otonomy pays cash up front plus milestone...

We will not see a Phase 2b trial in the United States this year. As I said, this is a case study in propaganda and obfuscation. Phase 2b in U.S. this year = pure fantasy. When were the Phase 2 trial results supposed to be published or reported? How many times has that due date been pushed back...

FYI AUD1001 (LY3056480) failed. Primary efficacy endpoints were not sufficiently met. But don't expect a big announcement from the companies or entities involved. Apparently it's a touchy subject... which requires layer upon layer of positive spin and reframing to avoid triggering any negative...

Bump.

The greatest tinnitus article of the last 2 decades was written over 7 years ago and has 0 citations.

archaic design is best design

Good share, @SallyM!

It's funny because the technical term for this type of single cell organism learning is habituation :LOL: https://royalsocietypublishing.org/doi/10.1098/rspb.2016.0446 *starts timer to see how long it will take for someone to post in the ttalk research/treatment section asking HAS ANYONE TRY...

Thank you for the additional context, @Justin De Moss.

Awesome

It's quite fun

"This lego device showed great improvement for a certain segment of patients. We are currently analyzing the data and determining which subtypes of patients will improve. But while we figure out who this lego device will actually work for, we invite ALL patients to come pay us money to find out...

This good meme

This is the confusing part. What does "is entering" mean here, exactly? I think it is important for statements like this to be much more clear... especially when they are presented in the context of a fundraising email (due to the legal implications that arise when soliciting funds).

I am confused and I wonder if the term "proof of concept" was used too loosely here. (In drug development, proof of concept has a specific/narrow meaning that is separate from proof of mechanism or proof of of principle.)

Agreed, plus this isn't unusual behavior.

The FTC has started going after companies that make use of fraudulent consumer testimonials. Examples below. You can file an FTC complaint/report online. https://www.ecfr.gov/cgi-bin/text-idx?SID=1891a45001dd9fc423d02ac3ec62b565&mc=true&node=pt16.1.255&rgn=div5...

Are you sure about that? Not meant to be taken literally... in which possible world?

Nowadays, whenever I hear about people who deny the existence of consciousness, I think of the "some people are NPCs" theory. Are there philosophical zombies among us??

@Contrast Agreed. I will keep my special research here from now on.

https://patents.google.com/patent/US10569082B2/en?inventor=Susan+Shore Hey YouTube, in the next 5 minutes I'm going to show you how to make your very own Applying electric currents by contact electrodes alternating or intermittent currents for stimulation device... Which was originally invented...

PIPE-505 trial is now recruiting. Recruitment Status was updated yesterday (July 20, 2020). Only one recruitment site so far (Florida). More soon, probably.

This research was funded in part by the Lauer Tinnitus Research Center Funding This work was supported by the Department of Defense grant W81XWH-15-1-0472, the National Institutes of Health grants R01 DC015824 (KS) and R01 DC014089 (AE), Nancy Sayles Day Foundation, Lauer Tinnitus Research...

Wow! Thank you for sharing all this information, @SallyM. :puppykisses: :thankyousign:

It can, I will show you the bird's eye view. Reach out.

I chose Bulbasaur as my original Gen 1 starter. He will always be my favorite. However, Charmander is a more powerful meme. In this case, Charmander keeping his flame alive in the rain represents hope, loyalty, endurance, resourcefulness, and many other meme-worthy qualities.

I just saw and replied to your email yesterday. You know where to find me.

Are you insane??? Kidnapping!? The correct term is curenapping... and we are but humble curenappers, tending to our scientists.

@Contrast get over here @GSC chime in @threefirefour memes plz

Awesome. I'm curious, what you have in mind. Would the researchers themselves be responsible for the pitch, or would Tinnitus Talk members help "summarize" or present the pitch. Or both?? I think it's a cool idea, wondering what the format would look like. And I wonder if some sort of...

https://www.tinnitustalk.com/threads/community-helping-identify-research-priorities-chirp.37023/ Summoning @JohnAdams

MARCH MADNESS!!! ... but for tinnitus researchers/projects instead of college basketball games... and not just March... every month... with sticky posts and forum badges instead of actual trophies... ROBOT WARS!!! ... but for tinnitus researchers/projects head-to-head battles instead of robot...

Abstinence. Literally the most secure form of cyber-security.

Book recommendation for you: https://en.wikipedia.org/wiki/The_True_Believer

They sure as heck wouldn't sell it for $10.99, that's all I know :D

Great idea.

Do you use macros?

I would love to hear an interview with Timothy Balmer RE: his ongoing Unipolar Brush Cells (UBCs) research.

That's my main concern, and why I am eager to see their published results. The excitement and hope surrounding the device is real, now show me the evidence and results from the recent clinical trials. Sooner the better!

I don't have them in list format at the moment but when I get a chance I will do some organizing and post them here.

The truth about Ring Relief... https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/warning-letters/b-jain-pharmaceuticals-private-limited-567957-03212019 1. Your firm failed to maintain the buildings used in the manufacture, processing, packing, or holding of...

Fun fact: there are 43 companies currently working on hearing restoration drugs right now :)

Phase 2 has not started yet but when it does they will announce it.

We will at least get the new study results abstract on September 18. (Possibly sooner, if the conference organizer decides to make the abstracts public before the conference itself begins... which isn't too uncommon.) As for the full text, the paper, that will depend on the embargo date and...

COMING THIS FALL Les Study Results de FX-322 Starring Susan King ft. Will McLean September 18, 2019 https://plan.core-apps.com/aao2019/event/d29afee0ef623a96e8827526a952c271

https://journals.lww.com/thehearingjournal/Fulltext/2019/05000/Hearing_Loss,_Tinnitus_Among_Special_Olympic.8.aspx Any future gold medal winners lurking here?

Not a problem - I should have clarified that my post wasn't to contradict or update what you reported regarding them not revealing inclusion criteria - just wanted to add context!

Here is the inclusion criteria from the OTO-313 study page, if anyone is curious: Inclusion Criteria: Subject has subjective unilateral tinnitus and is consistently aware of their tinnitus throughout much of the waking day. Subject is able to use the electronic diary to complete their daily...

You were right.

I could not find any other study on clinicaltrials.gov other than the one that was updated to "withdrawn" a few days ago. Are we sure this is not the same study?

;)

False, I have literally spent the last 3-4 months researching this exact topic. There are ways to legally get early access, ranging from "if you're rich and well-connected" to "they legally can't refuse you and it's a government program that nobody knows about (yet)". I would post the...

ITT: FALSE HOPE VS. FALSE NOPE.

sick gains bro